Christopher T Holman

US Patent:

20060118491, Jun 8, 2006

Filed:

Dec 1, 2005

Appl. No.:

11/292707

Inventors:

Douglas Gjerde - , US
Liem Nguyen - San Jose CA, US
Ronald Jones - Morgan Hill CA, US
Christopher Holman - Overland Park KS, US

International Classification:

B01D 15/08

US Classification:

210656000, 210198200, 436161000, 422070000, 435007100

Abstract:

The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the column between two frits. In some embodiments, the extraction columns employ modified pipette tips as column bodies. In some embodiments, the invention provides methods and devices for desalting and/or buffer exchange of a sample.