Clayton G Harris

US Patent:

7189724, Mar 13, 2007

Filed:

Apr 15, 2004

Appl. No.:

10/826439

Inventors:

Haoyun An - Carlsbad CA, US
Frank Rong - Irvine CA, US
Jim Wu - Aliso Viejo CA, US
Clayton Harris - Irvine CA, US
Suetying Chow - Diamond Bar CA, US

Assignee:

Valeant Research and Development - Costa Mesa CA

International Classification:

A01N 43/58
A01N 43/60
A61K 31/50
A61K 31/495
C07D 241/36

US Classification:

514249, 514250, 544344, 544347, 544353

Abstract:

The invention provides substituted quinoxalines having the general formulas.

US Patent:

7799913, Sep 21, 2010

Filed:

Nov 25, 2002

Appl. No.:

10/495049

Inventors:

Gary A. Rogers - Laguna Beach CA, US
Matthew Allan - Anaheim CA, US
Clayton Harris - Irvine CA, US
Jianjie Huang - Berkeley CA, US
Christopher M. Marrs - Foothill Ranch CA, US
Rudolf Mueller - Foothill Ranch CA, US
Stanislaw Rachwal - Irvine CA, US

Assignee:

Cortex Pharmaceuticals, Inc. - Irvine CA

International Classification:

C07D 265/12
C07D 265/14
C07D 491/04
C07D 498/04
C07D 513/04
C07D 515/04
A61K 31/536
A61K 31/5365
A61P 25/18

US Classification:

544 89, 544 92, 544 95, 5142305, 5142298, 5142295

Abstract:

This invention related to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed In a variety of dementias, and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson′s disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions and methods of using these compounds for such treatment.

US Patent:

6376573, Apr 23, 2002

Filed:

Jun 7, 1996

Appl. No.:

08/659879

Inventors:

Eugene W. White - Rossiter PA
Jack C. Debes - Carlsbad CA
Clayton G. Harris - Irvine CA
Edwin C. Shors - Costa Mesa CA

Assignee:

Interpore International - Irvine CA

International Classification:

A61K 200

US Classification:

523115, 523116, 623 10, 623 11, 623 12, 623 16

Abstract:

An improved porous ceramic biomaterial is disclosed in which a polymer such as polylactic acid is polymerized in situ to fill the micropores substantially without filling the macropores. The polymer reinforcement helps improve the strength of the implant while preserving its ability to support ingrowth of bone to help integrate the implant into its surgical environment.

US Patent:

20210401749, Dec 30, 2021

Filed:

Sep 7, 2021

Appl. No.:

17/468384

Inventors:

- Tokyo, JP
Gloria Hincapie - Aliso Viejo CA, US
Clayton Harris - Aliso Viejo CA, US

International Classification:

A61K 9/16
C08F 220/56
A61L 24/00
A61L 24/06
C08F 220/38
A61L 31/04
A61K 9/00

Abstract:

Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

US Patent:

20210023261, Jan 28, 2021

Filed:

Oct 6, 2020

Appl. No.:

17/064434

Inventors:

- Aliso Viejo CA, US
Michael J. Constant - Mission Viejo CA, US
Edward Michael Keeley - Huntington Beach CA, US
Rob Greene - Aliso Viejo CA, US
Clayton Harris - Aliso Viejo CA, US

International Classification:

A61L 24/06
A61L 24/00
A61K 49/04
A61K 49/12

Abstract:

Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological solution; wherein the biocompatible polymer is soluble in the non-physiological solution and insoluble in a physiological solution. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

US Patent:

20190338059, Nov 7, 2019

Filed:

Jul 19, 2019

Appl. No.:

16/516931

Inventors:

- Tokyo, JP
Gloria Hincapie - Aliso Viejo CA, US
Clayton Harris - Aliso Viejo CA, US

International Classification:

C08F 220/38
C08F 220/56
A61L 31/04
A61L 24/00
A61L 24/06
A61K 9/16
A61K 9/00

Abstract:

Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

US Patent:

20190192726, Jun 27, 2019

Filed:

Feb 27, 2019

Appl. No.:

16/287797

Inventors:

- Aliso Viejo CA, US
Michael J. Constant - Mission Viejo CA, US
Edward Michael Keeley - Huntington Beach CA, US
Rob Greene - Tustin CA, US
Clayton Harris - Tustin CA, US

International Classification:

A61L 24/06
A61L 24/00
A61K 49/04
A61K 49/12

Abstract:

Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological solution; wherein the biocompatible polymer is soluble in the non-physiological solution and insoluble in a physiological solution. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

US Patent:

20190194406, Jun 27, 2019

Filed:

Jan 25, 2019

Appl. No.:

16/258313

Inventors:

- Aliso Viejo CA, US
Gloria Hincapie - Tustin CA, US
Clayton Harris - Irvine CA, US
Yue Wu - Tustin CA, US

International Classification:

C08J 5/18
A61K 9/00
A61L 31/14
A61K 47/32
C08F 120/56
A61L 31/04
A61L 31/16

Abstract:

Biodegradable, cross-linked polymer films and methods of making the same are described. The polymer films can be used for preventing adhesions following surgery and/or delivering therapeutic agents.