David P Hunter

US Patent:

6400708, Jun 4, 2002

Filed:

Sep 28, 1998

Appl. No.:

09/161276

Inventors:

Dale L. Bartholomew - Vienna VA
Robert D. Farris - Sterling VA
Raymond I. Millet - Bowie MD
David D. Hunter - Herndon VA

Assignee:

Verizon Services Corp. - Arlington VA

International Classification:

H04J 312

US Classification:

370352, 370524, 379 9301

Abstract:

A number of proposals have been developed to provide data communications over two-wire copper circuits at rates equivalent to a number of combined ISDN B-channels. For example, for an ISDN rate digital subscriber line (IDSL), the circuit between the network termination at the customer premises and the channel bank carries data on two combined B-channels. An IDSL circuit cannot carry voice communications. Some such services carry the lower rate signaling D-channel only on the subscriber line circuit. Normal ISDN services carry voice services on one of the two B-channels, limiting data communications to the other B-channel. Normal ISDN services do carry the lower rate D-channel through the network, but this channel is used only for call set-up signaling, low speed data communications and the like. The invention uses two or more B-channels on the DSL circuit for data communications and transports voice telephone communications on the low speed signaling D-channel. The bearer (B) channels typically connect to a high speed data network, such as SMDS, for services such as Internet access.

US Patent:

6978561, Dec 27, 2005

Filed:

Apr 15, 2005

Appl. No.:

11/106810

Inventors:

David Gavin Hunter - Towson MD, US

International Classification:

G09F001/04

US Classification:

4012401, 4012403

Abstract:

An improved greeting card is presented that incorporates cellular bubble material, such as bubble wrap, into the images and or text thereon. The bubbles of the cellular bubble material may be popped, thereby providing an amusing and pleasurable activity for the recipient of the card. By making reference to the popping activity, the message on the card may be reinforced. The cellular bubble material provides pleasing visual and tactile features, and if used in quantity provides integral protection of the card and its contents.

US Patent:

60272163, Feb 22, 2000

Filed:

Oct 15, 1998

Appl. No.:

9/172842

Inventors:

David Lee Guyton - Baltimore MD
David George Hunter - Baltimore MD
Saurabh Navinchandra Patel - Monmouth Junction NJ
Julie Christine Sandruck - Rochester NY
Robert Lee Fry - New Windsor MD

Assignee:

The Johns University School of Medicine - Baltimore MD

International Classification:

A61B 310

US Classification:

351200

Abstract:

Apparatus and method are provided for assessing the direction of fixation of an eye by detecting polarization-related changes in light retroreflected from the fundus of the eye. Nerve fibers in the retina of the eye are birefringent and alter the polarization state of light traversing them as a function of their orientation. The nerve fibers are arrayed in a characteristic pattern in the retina, specifically radiating outward from the fovea and converging to the optic nerve head. By assessment of polarization-related changes in rctroreflected light from multiple retinal areas either sequentially or simultaneously, characteristic birefringence signatures of portions of the retina can be identified which are used to assess the direction of fixation of the eye. In addition, interference from the corneal birefringence is reduced by using incident light having a polarization state that is substantially independent of meridional direction. Circularly polarized light or non-polarized light is used for the assessment.

US Patent:

20220314010, Oct 6, 2022

Filed:

Nov 15, 2021

Appl. No.:

17/526254

Inventors:

- Baltimore MD, US
Ehud J. Schmidt - Boston MA, US
Ronald D. Watkins - Stanford CA, US
Harikrishna Tandri - Ellicott City MD, US
David Hunter - Baltimore MD, US
Leslie Tung - Columbia MD, US
Ronald D. Berger - Baltimore MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61N 1/39
A61B 5/055

Abstract:

A magnetic-resonance-imaging-compatible (MRI-compatible) cardiac defibrillator includes: a defibrillator generator; first and second electric wires, each being electrically connected to said defibrillator generator; first and second defibrillation pads, each being electrically connected to a respective one of said first and second electric wires; and a low pass filter electrically connected between said defibrillator generator and said first and second electric wires to prevent a noise in an MRI image caused by a radiofrequency interference from the defibrillator as well as protect a patient and the defibrillator from MRI radiofrequency imaging signals, wherein said low pass filter has a cutoff frequency set such that differential mode noise at an MRI Larmor frequency is in an attenuated band while a system-test signal by said defibrillator generator is in a pass band of said low pass filter.

US Patent:

20210290967, Sep 23, 2021

Filed:

Jun 8, 2021

Appl. No.:

17/342405

Inventors:

- Baltimore MD, US
Ronald David Berger - Baltimore MD, US
Seth Weinberg - Williamsburg VT, US
Leslie Tung - Baltimore MD, US
Henry Halperin - Baltimore MD, US
David Hunter - Baltimore MD, US

International Classification:

A61N 1/39
A61N 1/362
A61N 1/06
A61N 1/365

Abstract:

The present invention provides both methods and devices for termination of arrhythmias, such as ventricular or atrial tachyarrhythmias. The device and method involves application of alternating current (AC) for clinically significant durations at selected therapeutic frequencies through the cardiac tissue to a subject experiencing arrhythmia. Methods are also provided to minimize or eliminate pain during defibrillation.

US Patent:

20200086130, Mar 19, 2020

Filed:

Dec 8, 2017

Appl. No.:

16/467373

Inventors:

- Baltimore MD, US
Ehud J. Schmidt - Boston MA, US
Ronald D. Watkins - Stanford CA, US
Harikrishna Tandri - Ellicott City MD, US
David Hunter - Baltimore MD, US
Leslie Tung - Columbia MD, US
Ronald D. Berger - Baltimore MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61N 1/39
A61B 5/055

Abstract:

A magnetic-resonance-imaging-compatible (MRI-compatible) cardiac defibrillator includes: a defibrillator generator; first and second electric wires, each being electrically connected to said defibrillator generator; first and second defibrillation pads, each being electrically connected to a respective one of said first and second electric wires; and a low pass filter electrically connected between said defibrillator generator and said first and second electric wires to prevent a noise in an MRI image caused by a radiofrequency interference from the defibrillator as well as protect a patient and the defibrillator from MRI radiofrequency imaging signals, wherein said low pass filter has a cutoff frequency set such that differential mode noise at an MRI Larmor frequency is in an attenuated band while a system-test signal by said defibrillator generator is in a pass band of said low pass filter.

US Patent:

20180179190, Jun 28, 2018

Filed:

Jun 24, 2016

Appl. No.:

15/737334

Inventors:

- Rahway NJ, US
Jinlong Jiang - Scotch Plains NJ, US
Alexander Pasternak - Princeton NJ, US
Shuzhi Dong - Plainsboro NJ, US
Xin Gu - Scotch Plains NJ, US
Jack D. Scott - Scotch Plains NJ, US
Haiqun Tang - Belle Mead NJ, US
Zhiqiang Zhao - Scotch Plains NJ, US
Yuhua Huang - Westfield NJ, US
David Hunter - Hatfield PA, US
Dexi Yang - Livingston NJ, US
Katherine Young - Metuchen NJ, US
Li Xiao - Cranbury NJ, US
Zhibo Zhang - Beijing, CN
Jianmin Fu - Beijing, CN
Yunfeng Bai - Beijing, CN
Zhixiang Zheng - Beijing, CN
Xu Zhang - Beijing, CN

Assignee:

Marck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 403/14
A61K 45/06
A61K 31/4184
C07D 401/14
A61K 31/454
C07D 471/04
A61K 31/437
A61K 31/4545
C07D 487/04
A61K 31/5025
C07D 403/10
A61K 31/416
A61K 31/4439
C07D 417/14
A61K 31/428
A61K 31/4375
C07D 413/14
A61K 31/423
A61K 31/4709
A61K 31/4725
A61K 31/517
A61K 31/506
A61K 31/498
A61K 31/5377
A61P 31/04

Abstract:

The present invention relates to metallo-β-lactamase inhibitor compounds of Formula I: (I) and pharmaceutically acceptable salts thereof, wherein Z, R, X, Xand Rare as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.

US Patent:

20160333021, Nov 17, 2016

Filed:

Jan 16, 2015

Appl. No.:

15/110431

Inventors:

- Rahway NJ, US
Haifeng Tang - Metuchen NJ, US
Li Xiao - Cranbury NJ, US
Jing Su - Scotch Plains NJ, US
Guoqing Li - Belle Mead NJ, US
Shu-Wei Yang - Edison NJ, US
Weidong Pan - Hillsborough NJ, US
Haiqun Tang - Belle Mead NJ, US
Reynalda DeJesus - East Brunswick NJ, US
Jacqueline Hicks - Scotch Plains NJ, US
Matthew Lombardo - Flemington NJ, US
Hong Chu - Livingston NJ, US
William Hagmann - Westfield NJ, US
Alex Pasternak - Princeton NJ, US
Xin Gu - Scotch Plains NJ, US
Jinlong Jiang - Scotch Plains NJ, US
Shuzhi Dong - Plainsboro NJ, US
Clare London - Chatham NJ, US
Dipshikha Biswas - Woodbridge NJ, US
Katherine Young - Metuchen NJ, US
David N. Hunter - Scotch Plains NJ, US
Zhiqiang Zhao - Scotch Plains NJ, US
Dexi Yang - Livingston NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 491/048
A61K 31/41
A61K 45/06
A61K 31/407
A61K 31/197
C07D 405/12
A61K 31/5377
C07D 403/10
A61K 31/4192
A61K 31/496
C07D 401/10
A61K 31/454
A61K 31/4439
C07D 409/10
C07D 417/10
A61K 31/427
C07D 405/14
C07D 413/10
A61K 31/422
A61K 31/506
A61K 31/497
A61K 31/4178
A61K 31/501
A61K 31/4155
C07D 471/04
A61K 31/437
C07D 417/14
C07D 401/14
C07D 487/04
A61K 31/5025
A61K 31/4245
A61K 31/541
C07D 401/04
C07D 413/14
A61K 31/55
C07D 471/10
C07D 257/04

Abstract:

The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.