David M Hunter

US Patent:

20180179190, Jun 28, 2018

Filed:

Jun 24, 2016

Appl. No.:

15/737334

Inventors:

- Rahway NJ, US
Jinlong Jiang - Scotch Plains NJ, US
Alexander Pasternak - Princeton NJ, US
Shuzhi Dong - Plainsboro NJ, US
Xin Gu - Scotch Plains NJ, US
Jack D. Scott - Scotch Plains NJ, US
Haiqun Tang - Belle Mead NJ, US
Zhiqiang Zhao - Scotch Plains NJ, US
Yuhua Huang - Westfield NJ, US
David Hunter - Hatfield PA, US
Dexi Yang - Livingston NJ, US
Katherine Young - Metuchen NJ, US
Li Xiao - Cranbury NJ, US
Zhibo Zhang - Beijing, CN
Jianmin Fu - Beijing, CN
Yunfeng Bai - Beijing, CN
Zhixiang Zheng - Beijing, CN
Xu Zhang - Beijing, CN

Assignee:

Marck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 403/14
A61K 45/06
A61K 31/4184
C07D 401/14
A61K 31/454
C07D 471/04
A61K 31/437
A61K 31/4545
C07D 487/04
A61K 31/5025
C07D 403/10
A61K 31/416
A61K 31/4439
C07D 417/14
A61K 31/428
A61K 31/4375
C07D 413/14
A61K 31/423
A61K 31/4709
A61K 31/4725
A61K 31/517
A61K 31/506
A61K 31/498
A61K 31/5377
A61P 31/04

Abstract:

The present invention relates to metallo-β-lactamase inhibitor compounds of Formula I: (I) and pharmaceutically acceptable salts thereof, wherein Z, R, X, Xand Rare as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.

US Patent:

20160375995, Dec 29, 2016

Filed:

Dec 4, 2013

Appl. No.:

15/101762

Inventors:

- Startford CT, US
Eric Lucien NUSSENBLATT - Stamford CT, US
Bryan Kenneth BASKIN - Arlington TX, US
David H. HUNTER - Cheshire CT, US

International Classification:

B64C 27/32
B64C 27/10

Abstract:

A rotor hub assembly is provided including an open rotor hub having a base plate and a plurality of rotor members mounted about a circumference of the base plate. The rotor members are configured to form a plurality of rotor blade openings between adjacent rotor members, and a central opening between all of the rotor members. A plate includes a central body portion and a plurality of arms. Each of the plurality of arms is configured to mount to one of the plurality of rotor members such that the central body portion is generally positioned within the central opening of the open rotor hub.

US Patent:

20160333021, Nov 17, 2016

Filed:

Jan 16, 2015

Appl. No.:

15/110431

Inventors:

- Rahway NJ, US
Haifeng Tang - Metuchen NJ, US
Li Xiao - Cranbury NJ, US
Jing Su - Scotch Plains NJ, US
Guoqing Li - Belle Mead NJ, US
Shu-Wei Yang - Edison NJ, US
Weidong Pan - Hillsborough NJ, US
Haiqun Tang - Belle Mead NJ, US
Reynalda DeJesus - East Brunswick NJ, US
Jacqueline Hicks - Scotch Plains NJ, US
Matthew Lombardo - Flemington NJ, US
Hong Chu - Livingston NJ, US
William Hagmann - Westfield NJ, US
Alex Pasternak - Princeton NJ, US
Xin Gu - Scotch Plains NJ, US
Jinlong Jiang - Scotch Plains NJ, US
Shuzhi Dong - Plainsboro NJ, US
Clare London - Chatham NJ, US
Dipshikha Biswas - Woodbridge NJ, US
Katherine Young - Metuchen NJ, US
David N. Hunter - Scotch Plains NJ, US
Zhiqiang Zhao - Scotch Plains NJ, US
Dexi Yang - Livingston NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 491/048
A61K 31/41
A61K 45/06
A61K 31/407
A61K 31/197
C07D 405/12
A61K 31/5377
C07D 403/10
A61K 31/4192
A61K 31/496
C07D 401/10
A61K 31/454
A61K 31/4439
C07D 409/10
C07D 417/10
A61K 31/427
C07D 405/14
C07D 413/10
A61K 31/422
A61K 31/506
A61K 31/497
A61K 31/4178
A61K 31/501
A61K 31/4155
C07D 471/04
A61K 31/437
C07D 417/14
C07D 401/14
C07D 487/04
A61K 31/5025
A61K 31/4245
A61K 31/541
C07D 401/04
C07D 413/14
A61K 31/55
C07D 471/10
C07D 257/04

Abstract:

The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

US Patent:

20160303244, Oct 20, 2016

Filed:

Jun 24, 2016

Appl. No.:

15/191584

Inventors:

- Rahway NJ, US
Lin Yan - East Brunswick NJ, US
Ahmet Kekec - Hoboken NJ, US
Yuping Zhu - Basking Ridge NJ, US
David N. Hunter - Scotch Plains NJ, US
Pei Huo - Millburn NJ, US
Danqing Feng - Green Brook NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Christopher R. Moyes - Westfield NJ, US
Zhiqiang Zhao - Rahway NJ, US
Brenda Pipik - Edison NJ, US
Dmitri Pissarnitski - Scotch Plains NJ, US
Joseph L. Duffy - Cranford NJ, US
Erin N. Guidry - Cranford NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 47/48
C07K 14/62
A61K 38/28

Abstract:

Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.

US Patent:

20160251407, Sep 1, 2016

Filed:

Oct 2, 2014

Appl. No.:

15/025912

Inventors:

Songnian LIN - Kenilworth NJ, US
Lin YAN - Kenilworth NJ, US
Ahmet KEKEC - Kenilworth NJ, US
Yuping ZHU - Kenilworth NJ, US
David N. HUNTER - Kenilworth NJ, US
Pei HUO - Kenilworth NJ, US
Danqing FENG - Kenilworth NJ, US
Ravi P. NARGUND - Kenilworht NJ, US
Christopher R. MOYES - Kenilworth NJ, US
Zhiqiang ZHAO - Kenilworth NJ, US
Brenda PIPIK - Edison NJ, US
Dimitri PISSARNITSKI - Kenilworth NJ, US
Joseph L. DUFFY - Rahway NJ, US
Erin N. GUIDRY - Kenilworth NJ, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07K 14/62
A61K 38/28
A61K 47/48

Abstract:

Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.

US Patent:

20160176521, Jun 23, 2016

Filed:

May 1, 2015

Appl. No.:

14/702081

Inventors:

- Stratford CT, US
Eric Lucien Nussenblatt - Stamford CT, US
Justin Thomas - New Haven CT, US
Ryan Thomas Casey - San Diego CA, US
David H. Hunter - Cheshire CT, US

International Classification:

B64C 27/473
B64C 27/04
B64C 27/12
B64C 27/33
B64C 27/48

Abstract:

A rotor blade assembly includes a flex-beam member and a torque tube surrounding the flex-beam member and extending partially along a rotor blade assembly length. A rotor blade surrounds the flex beam member and extends from the torque tube to a blade tip. A connecting assembly secures the rotor blade and the torque tube at the flex-beam member. The connecting assembly includes a first connecting member extending at least partially into the rotor blade assembly through the rotor blade from a first rotor blade side and a second connecting member located at a second rotor blade side. A clamping load between the first connecting member and the second connecting member secures the rotor blade and torque tube to the flex-beam member.

US Patent:

20150158573, Jun 11, 2015

Filed:

Dec 5, 2013

Appl. No.:

14/097478

Inventors:

- Stratford CT, US
Eric L. Nussenblatt - Stamford CT, US
Ryan T. Casey - San Diego CA, US
Eric S. Parsons - New Haven CT, US
David H. Hunter - Cheshire CT, US

Assignee:

Sikorsky Aircraft Corporation - Stratford CT

International Classification:

B64C 1/00

Abstract:

A method of forming an in-wing device-retention assembly includes inserting a first plate into a wing, the wing having a wide end and a narrow end. The method includes inserting a second plate into the wing, inserting a wedge plate into the wing and positioning the wedge plate between the first plate and the second plate, and applying a force to the wedge plate in a direction toward the narrow end to fix the first plate, the second plate and the wedge plate within the wing.

US Patent:

20150105317, Apr 16, 2015

Filed:

Oct 2, 2014

Appl. No.:

14/504476

Inventors:

- Rahway NJ, US
Lin Yan - East Brunswick NJ, US
Ahmet Kekec - Hoboken NJ, US
Yuping Zhu - Basking Ridge NJ, US
David N. Hunter - Scotch Plains NJ, US
Pei Huo - Millburn NJ, US
Danqing Feng - Greenbrook NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Christopher R. Moyes - Westfield NJ, US
Zhiqiang Zhao - Rahway NJ, US
Brenda Pipik - Edison NJ, US
Dmitri Pissarnitski - Scotch Plains NJ, US
Joseph L. Duffy - Cranford NJ, US
Erin N. Guidry - Cranford NJ, US

International Classification:

A61K 47/48
A61K 38/28

US Classification:

514 59, 530399

Abstract:

Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.