David H Hunter

US Patent:

20020013834, Jan 31, 2002

Filed:

Dec 22, 1998

Appl. No.:

09/218564

Inventors:

JEFFREY ESAKOV - PENNINGTON NJ, US
SUZ HSI WAN - PRINCETON NJ, US
ANSLEY JESSUP - WILLINGBORO NJ, US
DAVID MICHAEL HUNTER - EWING NJ, US
LIVIU CHIRIAC - PLAINSBORO NJ, US

International Classification:

G06F015/173
G09G005/00

US Classification:

709/223000, 345/736000

Abstract:

Relationships among a plurality of web pages are indicated to a plurality of users. Icons are displayed, each of which corresponds to one of the web pages. Data associated with each of the pages is maintained for each of the users. This data may exist in the web page or be entered as a notation by each user. Data maintained locally for one user can be provided to another user. Web pages which have already been accessed are also indicated. A map is provided to guide the user so that the user may know which web pages have been accessed, which web pages are to be accessed next and what each web page means to the user Icons are added to the map for each material accessed. Links between icons may be established by the user or by the creator of the map. These links are displayed on the map as a user traverses among the accessible materials. The map may also exist at several levels such that the links and icons at a given level are collapsed into a single icon at the next lower or next higher level when that next lower or next higher level is viewed.

US Patent:

20160333021, Nov 17, 2016

Filed:

Jan 16, 2015

Appl. No.:

15/110431

Inventors:

- Rahway NJ, US
Haifeng Tang - Metuchen NJ, US
Li Xiao - Cranbury NJ, US
Jing Su - Scotch Plains NJ, US
Guoqing Li - Belle Mead NJ, US
Shu-Wei Yang - Edison NJ, US
Weidong Pan - Hillsborough NJ, US
Haiqun Tang - Belle Mead NJ, US
Reynalda DeJesus - East Brunswick NJ, US
Jacqueline Hicks - Scotch Plains NJ, US
Matthew Lombardo - Flemington NJ, US
Hong Chu - Livingston NJ, US
William Hagmann - Westfield NJ, US
Alex Pasternak - Princeton NJ, US
Xin Gu - Scotch Plains NJ, US
Jinlong Jiang - Scotch Plains NJ, US
Shuzhi Dong - Plainsboro NJ, US
Clare London - Chatham NJ, US
Dipshikha Biswas - Woodbridge NJ, US
Katherine Young - Metuchen NJ, US
David N. Hunter - Scotch Plains NJ, US
Zhiqiang Zhao - Scotch Plains NJ, US
Dexi Yang - Livingston NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 491/048
A61K 31/41
A61K 45/06
A61K 31/407
A61K 31/197
C07D 405/12
A61K 31/5377
C07D 403/10
A61K 31/4192
A61K 31/496
C07D 401/10
A61K 31/454
A61K 31/4439
C07D 409/10
C07D 417/10
A61K 31/427
C07D 405/14
C07D 413/10
A61K 31/422
A61K 31/506
A61K 31/497
A61K 31/4178
A61K 31/501
A61K 31/4155
C07D 471/04
A61K 31/437
C07D 417/14
C07D 401/14
C07D 487/04
A61K 31/5025
A61K 31/4245
A61K 31/541
C07D 401/04
C07D 413/14
A61K 31/55
C07D 471/10
C07D 257/04

Abstract:

The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

US Patent:

20160303244, Oct 20, 2016

Filed:

Jun 24, 2016

Appl. No.:

15/191584

Inventors:

- Rahway NJ, US
Lin Yan - East Brunswick NJ, US
Ahmet Kekec - Hoboken NJ, US
Yuping Zhu - Basking Ridge NJ, US
David N. Hunter - Scotch Plains NJ, US
Pei Huo - Millburn NJ, US
Danqing Feng - Green Brook NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Christopher R. Moyes - Westfield NJ, US
Zhiqiang Zhao - Rahway NJ, US
Brenda Pipik - Edison NJ, US
Dmitri Pissarnitski - Scotch Plains NJ, US
Joseph L. Duffy - Cranford NJ, US
Erin N. Guidry - Cranford NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 47/48
C07K 14/62
A61K 38/28

Abstract:

Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.

US Patent:

20150105317, Apr 16, 2015

Filed:

Oct 2, 2014

Appl. No.:

14/504476

Inventors:

- Rahway NJ, US
Lin Yan - East Brunswick NJ, US
Ahmet Kekec - Hoboken NJ, US
Yuping Zhu - Basking Ridge NJ, US
David N. Hunter - Scotch Plains NJ, US
Pei Huo - Millburn NJ, US
Danqing Feng - Greenbrook NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Christopher R. Moyes - Westfield NJ, US
Zhiqiang Zhao - Rahway NJ, US
Brenda Pipik - Edison NJ, US
Dmitri Pissarnitski - Scotch Plains NJ, US
Joseph L. Duffy - Cranford NJ, US
Erin N. Guidry - Cranford NJ, US

International Classification:

A61K 47/48
A61K 38/28

US Classification:

514 59, 530399

Abstract:

Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.