David J Lerner

US Patent:

6713074, Mar 30, 2004

Filed:

Jun 29, 2001

Appl. No.:

09/896566

Inventors:

David S. Lerner - Boca Raton FL
Gregory Schultz - Gainesville FL

Assignee:

Quick Med Technologies Inc. - Gainesville FL
University of Florida Research Foundation, Inc. - Gainesville FL

International Classification:

A61K 700

US Classification:

424401, 424 59, 514 23, 514 24, 514 25, 514 26, 514 33, 514182

Abstract:

The cosmetic topical formulation of this invention is directed toward diminishing skin wrinkling, fine line, improving skin tone, and combinations thereof. Preferably, the topical formulation contains a matrix metalloproteinase inhibitor, MMPI, and advantageously includes a natural estrogen, e. g. , a true estrogen compound, such as 17-beta estradiol, or an estrogen-like steroid, (such as various phytoestrogens found in herbal preparations), as opposed to a synthetic estrogen. Other forms of the cosmetic topical formulation of this invention include combinations of synthetic estrogen and MMP inhibitor. Exemplary synthetic estrogens include, but are not limited to, ethinyl estradiol and clomiphine citrate. The cosmetic topical formulation is safe and effective diminishing wrinkling, and improving skin tone. Certain compositions of this invention are useful for minimizing photodamage to skin, while in other embodiments, the composition according to this invention is useful to prevent or minimize the adverse effects on skin induced by cigarette smoking.

US Patent:

20020032904, Mar 14, 2002

Filed:

May 25, 2001

Appl. No.:

09/865319

Inventors:

David Lerner - Boca Raton FL, US

International Classification:

H04N007/173
H04N007/16

US Classification:

725/014000, 725/134000, 725/110000

Abstract:

The present invention relates to a system and method for collecting and transmitting data concerning the viewing habits of a viewer. The present invention instantaneously records the data concerning the viewing habits of the viewer while he or she watches programming on a television or streaming media on a conventional personal computer (PC) monitor.

US Patent:

20030083321, May 1, 2003

Filed:

Sep 25, 2002

Appl. No.:

10/256215

Inventors:

David Lerner - Boca Raton FL, US
Gregory Schultz - Gainesville FL, US

International Classification:

A61K031/56

US Classification:

514/171000

Abstract:

The invention pertains to compositions and methods to treat the adverse effects of mustard chemicals and other toxic compounds, such as chemical warfare agents, exposure to which normally induces vesicating type response in mammals. In a rodent eye model at fixed concentrations of such a vesicant, compositions comprising (a) a matrix metalloproteinase inhibitor, MMPI, and (b) a protease inhibitor, PI, such as a serine protease inhibitor, SPI, a significant reduction in morbidity is achieved with increased concentrations of the compositions of this invention, as compared with an MMPI inhibitor alone or vehicle alone. Furthermore, compositions comprising the MMPI, the SPI, and in addition, an anti-inflammatory compound, in a vehicle appropriate to the type of tissue damage to be protected against from vesicant exposure, achieves both reduction in total tissue damage and inflammation, as compared with anti-inflammatory composition alone. Chemicals having more than one property, such as MMPI and AIA properties, are also disclosed. Certain combinations disclosed are applied to treat injuries due to acids and bases.

US Patent:

20040185127, Sep 23, 2004

Filed:

Mar 1, 2004

Appl. No.:

10/790386

Inventors:

David Lerner - Boca Raton FL, US

International Classification:

A61K035/78
A61K007/42

US Classification:

424/764000, 514/033000, 424/059000

Abstract:

The cosmetic topical formulation of this invention is directed toward diminishing skin wrinkling, fine line, improving skin tone, and combinations thereof. Preferably, the topical formulation contains a matrix metalloproteinase inhibitor, MMPI, and advantageously includes a natural estrogen, e.g., a true estrogen compound, such as 17-beta estradiol, or an estrogen-like steroid, (such as various phytoestrogens found in herbal preparations), as opposed to a synthetic estrogen. Other forms of the cosmetic topical formulation of this invention include combinations of synthetic estrogen and MMP inhibitor. Exemplary synthetic estrogens include, but are not limited to, ethinyl estradiol and clomiphine citrate. The cosmetic topical formulation is safe and effective diminishing wrinkling, and improving skin tone. Certain compositions of this invention are useful for minimizing photodamage to skin, while in other embodiments, the composition according to this invention is useful to prevent or minimize the adverse effects on skin induced by cigarette smoking.

US Patent:

20220263889, Aug 18, 2022

Filed:

Feb 18, 2022

Appl. No.:

17/675829

Inventors:

- Carlsbad CA, US
David Lerner - Carlsbad CA, US

International Classification:

H04L 67/10
H04B 7/185
H04L 69/04
H04L 67/06
H04L 12/18
H03M 7/30
H04L 67/01
H04L 67/56

Abstract:

Systems and methods are described for avoiding redundant data transfers using delta coding techniques when reliably and opportunistically communicating data to multiple user systems. According to embodiments, user systems track received block sequences for locally stored content blocks. An intermediate server intercepts content requests between user systems and target hosts, and deterministically chucks and fingerprints content data received in response to those requests. A fingerprint of a received content block is communicated to the requesting user system, and the user system determines based on the fingerprint whether the corresponding content block matches a content block that is already locally stored. If so, the user system returns a set of fingerprints representing a sequence of next content blocks that were previously stored after the matching content block. The intermediate server can then send only those content data blocks that are not already locally stored at the user system according to the returned set of fingerprints.

US Patent:

20190379726, Dec 12, 2019

Filed:

Apr 16, 2019

Appl. No.:

16/385787

Inventors:

- Carlsbad CA, US
David Lerner - Carlsbad CA, US

International Classification:

H04L 29/08
H04B 7/185
H04L 29/06
H04L 12/18
H03M 7/30

Abstract:

Systems and methods are described for avoiding redundant data transfers using delta coding techniques when reliably and opportunistically communicating data to multiple user systems. According to embodiments, user systems track received block sequences for locally stored content blocks. An intermediate server intercepts content requests between user systems and target hosts, and deterministically chucks and fingerprints content data received in response to those requests. A fingerprint of a received content block is communicated to the requesting user system, and the user system determines based on the fingerprint whether the corresponding content block matches a content block that is already locally stored. If so, the user system returns a set of fingerprints representing a sequence of next content blocks that were previously stored after the matching content block. The intermediate server can then send only those content data blocks that are not already locally stored at the user system according to the returned set of fingerprints.

US Patent:

20170034256, Feb 2, 2017

Filed:

Aug 1, 2016

Appl. No.:

15/225538

Inventors:

- Carlsbad CA, US
David Lerner - Carlsbad CA, US

International Classification:

H04L 29/08
H04L 12/18
H04L 29/06

Abstract:

Systems and methods are described for avoiding redundant data transfers using delta coding techniques when reliably and opportunistically communicating data to multiple user systems. According to embodiments, user systems track received block sequences for locally stored content blocks. An intermediate server intercepts content requests between user systems and target hosts, and deterministically chucks and fingerprints content data received in response to those requests. A fingerprint of a received content block is communicated to the requesting user system, and the user system determines based on the fingerprint whether the corresponding content block matches a content block that is already locally stored. If so, the user system returns a set of fingerprints representing a sequence of next content blocks that were previously stored after the matching content block. The intermediate server can then send only those content data blocks that are not already locally stored at the user system according to the returned set of fingerprints.