A scroll type apparatus for fluid displacement is disclosed. In one embodiment, the apparatus includes an adjustment mechanism capable of being adjusted after assembly of the apparatus to close an axial gap between scroll members and account for manufacturing tolerances in apparatus components. In another embodiment, the apparatus includes an orbital scroll of two portions, with a supporting portion surrounding an eccentric bearing of higher density than that of a scroll portion. The center of mass of the orbital scroll is thus moved towards the eccentric bearing to reduce torquing of the scroll as it orbits. In a further embodiment, the apparatus includes an orbital scroll having two portions, a supporting portion surrounding an eccentric bearing having a lower coefficient of thermal expansion than that of a scroll portion, to reduce thermal expansion of the supporting portion, reducing misaligmnent of the eccentric orbital scroll on the bearing.
Peter Schultz - La Jolla CA, US Lei Wang - San Diego CA, US John Christopher Anderson - San Diego CA, US Jason William Chin - San Diego CA, US David R. Liu - Lexington MA, US Thomas J. Magliery - North Haven CT, US Eric L. Meggers - Philadelphia PA, US Ryan A. Mehl - San Diego CA, US Miro Pastrnak - San Diego CA, US Steven William Santoro - San Diego CA, US Zhiwen Zhang - San Diego CA, US
Assignee:
The Scripps Research Institute - La Jolla CA The Regents of the University of California - Oakland CA
The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
Methods And Compositions For The Production Of Orthogonal Trna-Aminoacyl Trna Synthetase Pairs
Peter Schultz - La Jolla CA, US Lei Wang - San Diego CA, US John Christopher Anderson - San Diego CA, US Jason Chin - San Diego CA, US David R. Liu - Lexington MA, US Thomas J. Magliery - North Haven CT, US Eric L. Meggers - La Jolla CA, US Ryan Aaron Mehl - San Diego CA, US Miro Pastrnak - San Diego CA, US Stephen William Santoro - San Diego CA, US Zhiwen Zhang - San Diego CA, US
Assignee:
The Scripps Research Institute - La Jolla CA The Regents of the University of California - Oakland CA
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
Methods And Composition For The Production Of Orthogonal Trna-Aminoacyltrna Synthetase Pairs
Peter G. Schultz - La Jolla CA, US Lei Wang - San Diego CA, US John Christopher Anderson - San Diego CA, US Jason Chin - Cambridge, GB David R. Liu - Lexington MA, US Thomas J. Magliery - North Haven CT, US Eric L. Meggers - Philadelphia PA, US Ryan Aaron Mehl - Lancaster PA, US Miro Pastrnak - San Diego CA, US Steven William Santoro - Cambridge MA, US Zhiwen Zhang - San Diego CA, US
Assignee:
The Scripps Research Institute - La Jolla CA The Regents of the University of California - Oakland CA
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
Peter Schultz - La Jolla CA, US Lei Wang - San Diego CA, US John Christopher Anderson - San Diego CA, US Jason W. Chin - Cambridge, GB David R. Liu - Lexington MA, US Thomas J. Magliery - North Haven CT, US Eric Meggers - Philadelphia PA, US Ryan Aaron Mehl - Lancaster PA, US Miro Pastrnak - San Diego CA, US Steven William Santoro - Cambridge MA, US Zhiwen Zhang - San Diego CA, US
Assignee:
The Scripps Research Institute - La Jolla CA The Regents of the University of California - Oakland CA
The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
Peter Schultz - La Jolla CA, US Lei Wang - San Diego CA, US John Christopher Anderson - San Diego CA, US Jason W. Chin - Cambridge, GB David R. Liu - Lexington MA, US Thomas J. Magliery - North Haven CT, US Eric Meggers - Philadelphia PA, US Ryan Aaron Mehl - Lancaster PA, US Miro Pastrnak - San Diego CA, US
Assignee:
The Scripps Research Institute - La Jolla CA The Regents of the University of California - Oakland CA
International Classification:
C12P 21/06 C12N 15/74 C12N 1/21
US Classification:
435 691, 43525233, 435488, 530350, 530351
Abstract:
The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
Methods And Composition For The Production Of Orthogonal Trna-Aminoacyltrna Synthetase Pairs
Peter G. Schultz - La Jolla CA, US Lei Wang - San Diego CA, US John Christopher Anderson - San Diego CA, US Jason Chin - Cambridge, GB David R. Liu - Lexington MA, US Thomas J. Magliery - North Haven CT, US Eric L. Meggers - Philadelphia PA, US Ryan Aaron Mehl - Lancaster PA, US Miro Pastrnak - San Diego CA, US Stephen William Santoro - Cambridge MA, US Zhiwen Zhang - San Diego CA, US
Assignee:
The Scripps Research Institute - La Jolla CA The Regents of the University of California - Oakland CA
International Classification:
C12P 21/06 C12N 9/00
US Classification:
435183, 435 691, 4352523, 435471
Abstract:
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
Peter Schultz - La Jolla CA, US Lei Wang - San Diego CA, US John Christopher Anderson - San Diego CA, US Jason W. Chin - Cambridge, GB David R. Liu - Lexington MA, US Thomas J. Magliery - North Haven CT, US Eric Meggers - Philadelphia PA, US Ryan Aaron Mehl - Lancaster PA, US Miro Pastrnak - San Diego CA, US Stephen William Santoro - Cambridge MA, US Zhiwen Zhang - San Diego CA, US
Assignee:
The Scripps Research Institute - La Jolla CA The Regents of the University of California - Oakland CA
International Classification:
C12N 9/90 C12N 15/74 C12P 21/02
US Classification:
435233, 435 691, 435488, 4353201, 536 235
Abstract:
The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
Dr. Liu graduated from the New York Medical College in 1996. He works in Mohawk, NY and 2 other locations and specializes in Internal Medicine and General Practice. Dr. Liu is affiliated with Little Falls Hospital and St Elizabeth Medical Center.
Dr. Liu graduated from the University of Buffalo, SUNY School of Medicine and Biomedical Sciences in 1977. He works in New York, NY and specializes in Nephrology and Internal Medicine. Dr. Liu is affiliated with Bellevue Hospital Center and NYU Langone Medical Center.
Beth Israel Hospital Cardiac Surgery 110 Francis St STE 2A, Boston, MA 02215 6176328383 (phone), 6176327562 (fax)
Education:
Medical School Tufts University School of Medicine Graduated: 1994
Procedures:
Coronary Artery Bypass Heart Valve Procedures Pacemaker and Defibrillator Procedures Septal Defect Repair Aortic Aneurysm Repair Removal Procedures on the Lungs and Pleura Thoracic Aortic Aneurysm Repair Thoracoscopy
Conditions:
Congenital Anomalies of the Heart
Languages:
English
Description:
Dr. Liu graduated from the Tufts University School of Medicine in 1994. He works in Boston, MA and specializes in Congenital Cardiac Surgery (Thoracic Surgery). Dr. Liu is affiliated with Beth Israel Deaconess Medical Center West Campus.
St Vincent Longevity Center 1 Saint Vincent Cir STE 210, Little Rock, AR 72205 5016604777 (phone), 5015524482 (fax)
Education:
Medical School China Med Univ, Shenyang City, Liaoning, China Graduated: 1984
Procedures:
Vaccine Administration Wound Care Acupuncture Electrocardiogram (EKG or ECG)
Conditions:
Alzheimer's Disease Anemia Anxiety Dissociative and Somatoform Disorders Atrial Fibrillation and Atrial Flutter Bipolar Disorder
Languages:
English
Description:
Dr. Liu graduated from the China Med Univ, Shenyang City, Liaoning, China in 1984. He works in Little Rock, AR and specializes in Internal Medicine - Geriatrics. Dr. Liu is affiliated with CHI St Vincent Infirmary Medical Center.
Kaiser Permanente Medical GroupKaiser Permanente Medical Center 3440 E Ln Palma Ave BLDG 1, Anaheim, CA 92806 7146442000 (phone), 7146447934 (fax)
Education:
Medical School Columbia University College of Physicians and Surgeons Graduated: 2000
Languages:
Chinese English French Spanish Vietnamese
Description:
Dr. Liu graduated from the Columbia University College of Physicians and Surgeons in 2000. He works in Anaheim, CA and specializes in Anesthesiology. Dr. Liu is affiliated with Kaiser Permanente Orange County Anaheim Medical Center.
Jan 2012 to 2000 Bioinformatics Data AnalystPfizer San Diego, CA Aug 2010 to Jan 2012 Technology Specialist - AssociatePfizer San Francisco, CA Feb 2010 to Aug 2010 Bioinformatics Assistant - Contractor
Education:
University of California San Diego, CA 2006 to 2010 B.S. in Bioengineering/Bioinformatics
Skills:
User-Friendly Web Design, AWS, Java, JavaScript, Jquery, AJAX, C++, C, SQL, Python, Perl, PHP, Data Structures, Algorithms, Linux, UI development, Object Oriented Design, Samtools, Bwa, Hmmer, Bowtie, MVC, RESTful, LSF, Wiki API, Google Web Tool (GWT), Jalview, Blast, R, Sharepoint, Infopath
My Name is David LIu(柳森).I have spent over 11 years in the wine industry. In that time I have done most things- learning about wine in College of... My Name is David LIu(柳森).I have spent over 11 years in the wine industry. In that time I have done most things- learning about wine in College of Enology of Northwest A&F University , working in China Wine Platform as Wine Culture Reasearch and Education Controller, buying, marketing and...
The company was founded in 1996 by husband-and-wife entrepreneurs David Liu and Carley Roney, and their partners Michael Wolfson and Rob Fassino, with $1.6 million in seed funding from AOL. Liu and Roneys own wedding in Washington D.C. had been a comedy of errors, and they saw a major need for tech
Date: Aug 03, 2023
Category: Business
Source: Google
US sales of guns and ammunition soar amid coronavirus panic buying
People are panicking because they dont feel secure. They worry about a riot or maybe that people will start to target the Chinese, David Liu, a Chinese-American gun dealer outside Los Angeles, told the Trace.
Date: Mar 16, 2020
Category: U.S.
Source: Google
Leading scientists call for global moratorium on creating 'CRISPR babies'
The authors calling for a moratorium include Feng Zhang of the Broad Institute and Emmanuelle Charpentier of Berlins Max Planck Institute for the Study of Pathogens, two of the scientists who, separately, led the development of CRISPR for genome editing; Harvard Universitys David Liu, who invented
Date: Mar 13, 2019
Category: Health
Source: Google
Chinese scientist claiming gene-edited babies reports second pregnancy
I feel more disturbed now, said David Liu of Harvard and MITs Broad Institute and inventor of a variation of the gene-editing tool. Its an appalling example of what not to do about a promising technology that has great potential to benefit society. I hope it never happens again.
Date: Nov 28, 2018
Category: Headlines
Source: Google
CRISPR trailblazers Zhang, Liu and Joung join forces to launch Beam with $87M and cutting-edge gene-editing tech
The new company called Beam Therapeutics is stepping out Monday with $87 million in launch money. Investors are backing true trailblazers in gene editing, as Beams scientific founders include David Liu, now-serial entrepreneur Feng Zhang, and J Keith Joung. All three are scientific founders of
Gao performed the research while a postdoctoral associate under the guidance of David Liu at Harvard University. She says that while hearing diseases are typically not life-threatening, hearing loss is the most common human sensory impairment and has a substantial impact on individuals and society.
Date: Dec 21, 2017
Category: Health
Source: Google
Gene-editing breakthrough found to minimize hearing loss in mice could help humans
Sometimes the mouse model is a good approximation of how the human patient behaves and sometimes not, said David Liu, a professor in the department of chemistry and chemical biology at Harvard University who led the work.
Date: Dec 21, 2017
Category: Sci/Tech
Source: Google
Scientists Use Gene Editing To Prevents A Form Of Deafness in Mice
"We're hopeful that our results will help guide the development of such strategies," says David Liu, a genetic engineer at Broad Institute, the Massachusetts Institute of Technology and Harvard University. The results were reported Wednesday in the journal Nature.
Date: Dec 20, 2017
Category: Health
Source: Google
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