David M Mccomsey

US Patent:

42105900, Jul 1, 1980

Filed:

Jan 6, 1978

Appl. No.:

5/867564

Inventors:

Bruce E. Maryanoff - Solebury Township, Bucks County PA
David F. McComsey - Philadelphia PA

Assignee:

McNeil Laboratories, Incorporated - Fort Washington PA

International Classification:

C07D20904
C07D20994
C07D48704

US Classification:

26032611R

Abstract:

A method for reducing indole compounds to the corresponding indoline compounds substantially free of undesirable side reactions is described. The method involves contacting an indole compound with a borane complex reagent in the presence of trifluoroacetic acid. The method is rapidly and readily carried out and provides an excellent method for preparing certain indoline compounds from the corresponding indole compounds. A novel dioxyborane useful as a borane reagent is also disclosed.

US Patent:

40595838, Nov 22, 1977

Filed:

Oct 13, 1976

Appl. No.:

5/731866

Inventors:

David Fred McComsey - Philadelphia PA
Michael John Zelesko - Warminster PA

Assignee:

McNeil Laboratories, Incorporated - Fort Washington PA

International Classification:

C07D20930

US Classification:

2602565R

Abstract:

Substituted thioindoles and their sulfoxide and sulfone derivatives, useful as cardiac rate lowering agents and for other pharmacological properties, and precursors therefor.