David L Rosen

US Patent:

7622438, Nov 24, 2009

Filed:

Jul 12, 2006

Appl. No.:

11/457088

Inventors:

Mirella Lazarov - Hayward CA, US
Catherine Middleton-Hardie - Hayward CA, US
David Rosen - Hayward CA, US

Assignee:

Acologix, Inc. - Hayward CA

International Classification:

A61K 38/18
C07K 14/51
A61F 2/00

US Classification:

514 2, 530399, 424422

Abstract:

Formulations and methods to promote biological processes to form or regenerate new hard tissues such as bones, cartilage, and/or dental tissues are disclosed. The formulation enhances biological activities of a hard tissue growth and differentiation factor characterized by specific and selective upregulation and/or extension of the retention time of the intracellular enzymes and signaling molecules that play important roles to proliferate, differentiate, maturate, and/or mineralize the hard tissue forming cells.

US Patent:

7638486, Dec 29, 2009

Filed:

Jul 12, 2006

Appl. No.:

11/457091

Inventors:

Mirella Lazarov - Hayward CA, US
Catherine Middleton-Hardie - Hayward CA, US
David Rosen - Hayward CA, US

Assignee:

Acologix, Inc. - Hayward CA

International Classification:

A61K 38/18
C07K 14/51
A61F 2/00

US Classification:

514 2, 530399, 424422

Abstract:

Formulations and methods to promote biological processes to form or regenerate new hard tissues such as bones, cartilage, and/or dental tissues are disclosed. The formulation comprising two proteins is administered to enhance biological activities of a hard tissue growth and differentiation factor characterized by specific and selective upregulation and/or extension of the retention time of the intracellular enzymes and signaling molecules that play important roles to proliferate, differentiate, maturate, and/or mineralize the hard tissue forming cells.

US Patent:

7888462, Feb 15, 2011

Filed:

Jan 22, 2008

Appl. No.:

12/018080

Inventors:

Catherine Middleton-Hardie - Hayward CA, US
Mirella Lazarov - Hayward CA, US
David Rosen - Hayward CA, US

Assignee:

Acologix, Inc. - Emeryville CA

International Classification:

C07K 14/00

US Classification:

530324, 530325, 530326, 514 2, 514 12

Abstract:

The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.

US Patent:

8227202, Jul 24, 2012

Filed:

Jul 10, 2009

Appl. No.:

12/460029

Inventors:

Wendy J. Fantl - San Francisco CA, US
David B. Rosen - San Francisco CA, US
Alessandra Cesano - Redwood City CA, US
Santosh K. Putta - Foster City CA, US
Garry Nolan - San Francisco CA, US
Aileen Cohen - Palo Alto CA, US
Erik Evensen - Foster City CA, US

Assignee:

Nodality, Inc. - South San Francisco CA

International Classification:

G01N 33/53
G01N 33/567
G01N 33/00

US Classification:

435 721, 435 723, 435 724, 435 614

Abstract:

The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

US Patent:

8242248, Aug 14, 2012

Filed:

Mar 23, 2010

Appl. No.:

12/730170

Inventors:

David Soper - San Francisco CA, US
David Rosen - Mountain View CA, US
Ying-Wen Huang - Palo Alto CA, US
Wendy Fantl - San Francisco CA, US

Assignee:

Nodality, Inc. - South San Francisco CA

International Classification:

C07K 16/00

US Classification:

5303871

Abstract:

As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation.

US Patent:

8273544, Sep 25, 2012

Filed:

Apr 8, 2011

Appl. No.:

13/083156

Inventors:

Wendy J. Fantl - San Francisco CA, US
David B. Rosen - Mountain View CA, US
Alessandra Cesano - Redwood City CA, US
Santosh K. Putta - Foster City CA, US
James R. Hackett - San Jose CA, US
Michael Walker - Mountain View CA, US
Jing Shi - Mountain View CA, US

Assignee:

Nodality, Inc. - South San Francisco CA

International Classification:

G01N 33/53
G01N 33/567
G01N 33/00

US Classification:

435 721, 435 723, 435 724, 435 614

Abstract:

The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

US Patent:

8399206, Mar 19, 2013

Filed:

Oct 22, 2010

Appl. No.:

12/910769

Inventors:

Wendy J. Fantl - San Francisco CA, US
David B. Rosen - Mountain View CA, US
Alessandra Cesano - Redwood City CA, US
Santosh K. Putta - Foster City CA, US
James R. Hackett - San Jose CA, US
Michael Walker - Mountain View CA, US
Jing Shi - Mountain View CA, US

Assignee:

Nodality, Inc. - South San Francisco CA

International Classification:

G01N 33/53
G01N 33/567
G01N 33/00

US Classification:

435 721, 435 723, 435 724

Abstract:

The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

US Patent:

8426558, Apr 23, 2013

Filed:

Dec 15, 2010

Appl. No.:

12/968532

Inventors:

Catherine Middleton-Hardie - Hayward CA, US
Mirella Lazarov - Hayward CA, US
David Rosen - Hayward CA, US

Assignee:

OrthoTrophix, Inc. - Foster City CA

International Classification:

C07K 14/00

US Classification:

530324, 530326, 514 168, 514 213

Abstract:

The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.