Deborah Kay Wilson

Address:

1676 Sebring Hl Dr, Henderson, NV 89052

VIN:

5GZCZ33D27S828793

Make:

SATURN

Model:

VUE

Year:

2007

Address:

1710 Wagon Gap Trl, Houston, TX 77090

VIN:

WBAVA37597NL15119

Make:

BMW

Model:

3 SERIES

Year:

2007

US Patent:

6372249, Apr 16, 2002

Filed:

Oct 24, 1994

Appl. No.:

08/327874

Inventors:

James R. Smith - Houston TX
David J. Drutz - Houston TX
Deborah R. Wilson - Houston TX
Louis A. Zumstein - Houston TX

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

A61K 9127

US Classification:

424450, 514 2, 514 12, 530350

Abstract:

The use of liposomal formulations, particularly formulations of positively charged and neutral lipids facilitates cellular uptake of SDI molecules. The transcription and/or expression of SDI-1-encoding nucleic acid molecules is facilitated by constructs that contain intervening untranslated regions.

US Patent:

6726907, Apr 27, 2004

Filed:

Apr 24, 2000

Appl. No.:

09/556570

Inventors:

Shuyuan Zhang - Sugar Land TX
Capucine Thwin - Seattle WA
Zheng Wu - Sugarland TX
Toohyon Cho - Philadelphia PA
Deborah R. Wilson - Houston TX
Lucetta Caston - Limerick PA

Assignee:

Introgen Therapeutics, Inc. - Austin TX

International Classification:

C12N 700

US Classification:

424 932, 4242331, 4241991, 424 936, 4352351, 4353201, 435239

Abstract:

The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production witrh cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.

US Patent:

7445930, Nov 4, 2008

Filed:

Jul 30, 2004

Appl. No.:

10/909066

Inventors:

Shuyuan Zhang - Sugarland TX, US
Capucine Thwin - Seattle WA, US
Zheng Wu - Sugarland TX, US
Toohyon Cho - Philadelphia PA, US
Deborah Wilson - Houston TX, US
Lucetta Caston - Limerick PA, US

Assignee:

Introgen Therapeutics Inc. - Austin TX

International Classification:

C12N 15/00
A61K 39/00
A61K 39/23
A61K 39/095

US Classification:

4353201, 4241841, 4242331

Abstract:

The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production witrh cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.

US Patent:

7510875, Mar 31, 2009

Filed:

Dec 27, 2001

Appl. No.:

10/033571

Inventors:

Shuyuan Zhang - Sugarland TX, US
Capucine Thwin - Seattle WA, US
Zheng Wu - Sugarland TX, US
Toohyon Cho - Philadelphia PA, US
Deborah Wilson - Houston TX, US
Lucetta Caston - Limerick PA, US

Assignee:

Introgen Therapuetics, Inc. - Austin TX

International Classification:

C12N 7/02
C12N 5/00
A61K 39/235
C07K 1/00
A23J 1/00

US Classification:

435329, 4242331, 435383, 530417

Abstract:

The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.

US Patent:

7776292, Aug 17, 2010

Filed:

Jan 13, 2005

Appl. No.:

10/597191

Inventors:

Deborah E. Wilson - Dunn Loring VA, US
Katherine K. Lock - Bethesda MD, US
Murray L. Cohen - Fort Worth TX, US
Thomas E. McWhorter - Allentown PA, US
Aaron A. Rosenblatt - New York NY, US
Theodore J. Traum - Rio Rancho NM, US

Assignee:

CDIC, Inc. - Atlanta GA
The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC
CDG Research Corporation - Bethlehem PA

International Classification:

A61L 2/00
A61L 9/00
A61L 2/20
B01J 19/12
B01D 53/50
B01D 53/68
B01D 21/00
A62D 3/00
C07C 1/00
C07C 2/00
C07C 4/00
C07C 5/00
C07C 6/00

US Classification:

422295, 422 22, 422 23, 422 32, 422 33, 42218607, 422292, 422298, 422304, 20415715, 20415743, 210748, 423240 R, 588299

Abstract:

The present disclosure relates to the decontamination of articles contaminated (or thought to be contaminated) with bioweapons, such as methods and apparatus for decontaminating articles contaminated with sporualated bioweapons. In some embodiments, the methods are methods of decontaminating an environment, for example a room or building contaminated with a bioweapon.

US Patent:

20070155008, Jul 5, 2007

Filed:

Aug 23, 2006

Appl. No.:

11/508780

Inventors:

Shuyuan Zhang - Sugar Land TX, US
Capucine Thwin - Sugar Land TX, US
Zheng Wu - Sugar Land TX, US
Toohyon Cho - Houston TX, US
Deborah Wilson - Houston TX, US
Lucetta Caston - Limerick PA, US

Assignee:

INTROGEN THERAPEUTICS INC. - Austin TX

International Classification:

C12P 21/06
C12N 15/00

US Classification:

435320100, 435069100

Abstract:

The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.

US Patent:

20080286147, Nov 20, 2008

Filed:

Oct 18, 2005

Appl. No.:

11/666054

Inventors:

Deborah E. Wilson - Dunn Loring VA, US
Murray L. Cohen - Fort Worth TX, US
Thomas McWhorter - Allentown PA, US

Assignee:

GOVERNMENT OF THE U.S.A. OF AMERICA AS REPRESENTED - Rockville MD
CDG RESEARCH CORPORATION - Bethlehem PA
CDIC, INC. - Atlanta GA

International Classification:

A61L 2/20

US Classification:

422 37, 422292

Abstract:

The present disclosure relates to the decontamination of articles or areas contaminated with one or more pathogens. Methods and apparatuses are disclosed that can be used to decontaminate an environment, for example a room, building, or articles contaminated with a pathogen.

US Patent:

61334162, Oct 17, 2000

Filed:

Aug 22, 1997

Appl. No.:

8/918712

Inventors:

Deborah R. Wilson - Houston TX
Therese M. Timmons - Houston TX
Julia A. Lee - Houston TX
Brian D. Almond - Houston TX
Jack A. Roth - Houston TX

Assignee:

The University of Texas System Board of Regents - Austin TX

International Classification:

C07K 200
C07K 400
C07K 500
A61K 4500

US Classification:

530300

Abstract:

The present invention involves the identification of a factor or factors that are anti-proliferative and can be used in the treatment of cancers and other hyperproliferative disease states. The factor or factors are induced from cells follow contact of the cells with viral or plasmid expression vectors. One factor is between about 3 kDa and 300 kDa in size, while another is less than about 3 kDa in size. Both are heat stable and is resistant to both protease and nuclease treatment. Methods for purification and use of the factor also are disclosed.