Edward T Hunter

US Patent:

6358533, Mar 19, 2002

Filed:

Jan 4, 2001

Appl. No.:

09/754760

Inventors:

Bob E. Sherwood - Amenia NY
John H. Staniforth - Bath, GB
Edward A. Hunter - Glenham NY

Assignee:

Edward Mendell, Co., Inc. - Patterson NY

International Classification:

A61K 914

US Classification:

424494, 424489, 424495, 424469, 424470, 428402

Abstract:

A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0. 1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.

US Patent:

6391337, May 21, 2002

Filed:

Mar 2, 2001

Appl. No.:

09/798755

Inventors:

Edward A. Hunter - Glenham NY
Bob E. Sherwood - Amenia NY
Joseph A. Zeleznik - New Paltz NY

Assignee:

Edward Mendell Co., Inc. - Patterson NY

International Classification:

A61K 920

US Classification:

424474, 424489, 424490, 424464, 424465, 424497

Abstract:

Direct compressed solid pharmaceutical dosage forms containing: a) from about 40 to about 95% by weight acetaminophen; b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; and c) from about 0. 01 to about 4. 0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i. e.

US Patent:

6395303, May 28, 2002

Filed:

Jun 4, 1997

Appl. No.:

08/868745

Inventors:

John N. Staniforth - Bath, GB
Bob E. Sherwood - Amenia NY
Edward A. Hunter - Glenham NY
Clifford M. Davidson - Morganville NJ

Assignee:

Edward Mendell Co., Inc. - Patterson NY

International Classification:

A61K 914

US Classification:

424499, 424464, 424468, 424480, 424486, 424487, 424488, 424494, 424489

Abstract:

The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising preparing an aqueous slurry of microcrystalline cellulose and a microcrystalline cellulose compressibility augmenting agent and an active agent. The augmenting agent is capable of physically restricting the proximity of the interface between adjacent cellulose surfaces and/or inhibiting interactions between adjacent cellulose surfaces, for example, via the creation of a hydrophobic boundary at cellulose surfaces. The resulting aqueous slurry is dried in a manner which inhibits quasi-hornification, thereby obtaining an agglomerated material which is directly compressible into a solid dosage form.

US Patent:

6471994, Oct 29, 2002

Filed:

Aug 27, 1999

Appl. No.:

09/384130

Inventors:

John N. Staniforth - Bath, GB
Bob E. Sherwood - Amenia NY
Edward A. Hunter - Cadosia NY

Assignee:

Edward Mendell Co., Inc. - Patterson NY

International Classification:

A16K 914

US Classification:

424489, 424490, 424499, 424464, 264112, 264115

Abstract:

A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0. 1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of from about 0. 5 to 2. 5% LOD, preferably between about 0. 5 and about 1.

US Patent:

6521261, Feb 18, 2003

Filed:

Oct 16, 2001

Appl. No.:

09/981319

Inventors:

Bob E. Sherwood - Amenia NY
John H. Staniforth - Bath, GB
Edward A. Hunter - Glenham NY

Assignee:

Edward Mendell Co., Inc. - Patterson NY

International Classification:

A61K 914

US Classification:

424494, 424400, 424489, 424495, 424469, 424470

Abstract:

A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0. 1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.

US Patent:

6746693, Jun 8, 2004

Filed:

Oct 8, 2002

Appl. No.:

10/266518

Inventors:

John N. Staniforth - Bath, GB
Bob E. Sherwood - Amenia NY
Edward A. Hunter - Cadosia NY

Assignee:

J. Rettenmaier Soehne GmbH + Co. KG - Rosenberg

International Classification:

A61K 914

US Classification:

424489, 424464, 424465, 424479, 424480, 424490, 424499, 264112, 264115

Abstract:

A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0. 1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of of from about 0. 5 to 2. 5% LOD, preferably between about 0. 5 and about 1.

US Patent:

6852336, Feb 8, 2005

Filed:

Apr 1, 2002

Appl. No.:

10/113867

Inventors:

Edward A. Hunter - Glenham NY, US
Bob E. Sherwood - Amenian NY, US
Joseph A. Zeleznik - New Paltz NY, US

Assignee:

J. Rettenmaier & Soehne GmbH + Co. KG - Rosenberg

International Classification:

A61K009/14
A61K009/16
A61K009/20
A61K009/28

US Classification:

424489, 424490, 424497, 424464, 424465, 424474

Abstract:

Direct compressed solid pharmaceutical dosage forms containing:.

US Patent:

6858231, Feb 22, 2005

Filed:

Jan 8, 2003

Appl. No.:

10/338361

Inventors:

Bob E. Sherwood - Amenia NY, US
John H. Staniforth - Bath, GB
Edward A. Hunter - Glenham NY, US

Assignee:

J. Rettenmaier & Soehne GmbH + Co. KG - Rosenberg

International Classification:

A61K009/14

US Classification:

424494, 424400, 424464, 424465, 424489, 424490, 10615451

Abstract:

A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0. 1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.