Erwin Goldberg - Evanston IL Jose L. Millan - San Diego CA
Assignee:
Northwestern University - Evanston IL
International Classification:
C07K 708 C07K 706 C07K 710
US Classification:
530326
Abstract:
Synthetic peptide compounds are provided which are capable of producing antibodies binding to the lactate dehydrogenase enzyme of human serum (LDH-C. sub. 4). The peptide compounds comprise antigenic sequences of human LDH-C. sub. 4. The peptide compounds can be used to prepare vaccines for reducing the fertility of women.
Erwin Goldberg - Evanston IL Thomas E. Wheat - Chicago IL
Assignee:
Northwestern University - Evanston IL
International Classification:
C07C10352
US Classification:
2601125R
Abstract:
The novel antigenic linear peptides of this invention comprise peptides of from 4 to 13 amino acids, which are characterized by containing the sequence valine-leucine-aspartic acid-methionine. These compounds correspond with the amino acids 231 to 243, or segments thereof including sequence 239-242 of mouse LDH-C. sub. 4. The coupounds have utility in vaccines for reducing the fertility of female mammals.
The novel antigenic linear peptide compound of this invention comprises a sequence of ten amino acids namely, serine-leucine-asparagine-proline-alanine-isoleucine-glycine-threonine-asp artic acid-lysine, all of the amino acids being in their L-forms with the exception of glycine. The compound has utility in vaccines for reducing the fertility of mammals.
The novel antigenic linear peptide compounds of this invention comprise sequences of from 10 to 14 amino acids which include the sequence arginine-methionine-valine-serine-glycine-glutamine-threonine-arginine-leu cine-aspartic acid, all of the amino acids with the exception of glycine being in their L-forms. The compounds have utility in vaccines for reducing fertility of mammals.
Erwin Goldberg - Evanston IL Thomas E. Wheat - Chicago IL
Assignee:
Northwestern University - Evanston IL
International Classification:
C07C10352
US Classification:
2601125R
Abstract:
The novel antigenic linear peptide of this invention comprise a linear peptide of 13 amino acids, comprising the sequence Val-Asn-Met-Thr-Ala-Gly-Glu-Glu-Gly-Leu-Leu-Lys-Lys. This compound corresponds with the amino acids 304 to 316 of mouse LDH-C. sub. 4. The compound has utility in vaccines for reducing the fertility of female mammals.
The novel antigenic linear peptide compound of this invention comprises a sequence of nine amino acids; namely, arginine-methionine-valine-serine-glycine-glutaminethreonine-arginine-leuc ine, all of the amino acids with the exception of glycine being in their L-forms. The compound has utility in vaccines for reducing fertility of mammals.
The novel antigenic peptide compounds of this invention comprise sequences of 12 to 19 amino acids, which include twelve amino acid sequence glutamic acid-glutamine-leucine-isoleucine-glutamine-asparagine-leucine-valine-prol ine-glutamic acid-aspartic acid-lysine, all of the amino acids being in their L-forms. The compounds have utility in vaccines for reducing the fertility of mammals.
The novel antigenic linear peptide compounds of this invention are characterized by providing a sequence of eight amino acids comprising isoleucine-serine-glycine-phenylalanine-proline-valine-glycine-arginine, all of the amino acids with the exception of glycine being in their L-forms. The isoleucine may comprise the N-terminal end or may be bonded to N-terminal glycine, and the arginine may be the C-terminal amino acid or may be bonded to C-terminal valine. The compounds have utility in vaccines for reducing the fertility of mammals.