Frederick Walters

from Ramseur, NC

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Frederick Walters Phones & Addresses

Ramseur, NC
Siler City, NC

Us Patents

Engineering Zymogen For Conditional Toxicity
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US Patent:

20110023194, Jan 27, 2011
Filed:

Dec 10, 2008
Appl. No.:

12/747247
Inventors:

Jeng Shong Chen - Chapel Hill NC, US
Frederick S. Walters - Durham NC, US
Assignee:

SYNGENTA PARTICIPATIONS AG - Research Triangle Park NC
International Classification:

A01H 5/00
C12N 9/10
C07H 21/00
C12N 15/63
C12N 5/10
C12N 1/19
C12N 1/16
US Classification:

8003201, 435193, 536 232, 4353201, 435419, 435412, 800298, 4352542, 43525421, 4352551
Abstract:

The ADP-ribosyltransferase, Vip2, exerts its intracellular toxicity in insects by modifying actin and preventing actin polymerization. Due to the nature of this toxin, expression of Vip2 in planta is lethal to the plant. Described herein are methods of making zymogens of toxic proteins that are benign in a non-target organism and are activated in a target organism. Disclosed herein are methods of engineering a random propeptide library at a terminus of a toxic protein and selecting for malfunctional variants in yeast. Using this method a selected proenzyme possesses reduced enzymatic activity as compared to the wild-type Vip2 protein, but remains a potent toxin towards corn rootworm larvae. The Vip2 zymogen can be proteolytically activated by corn rootworm digestive proteases.

Resumes

Frederick Walters

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Frederick Walters

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Frederick Walters

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Frederick Walters

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Location:

United States

Frederick Walters

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Location:

United States

Isbn (Books And Publications)

Sequential Simplex Optimization: A Technique for Improving Quality and Productivity in Research, Development, and Manufacturing

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Author
Frederick H. Walters

ISBN #
0849358949

Wikipedia References

Frederick Walters

About:

Born:

1849

Died:

1931

Work:

Position:

Scottish architect • Architect of Roman Catholic churches • Articled Clerk

Business category:

Churches

Education:

Specialty:

Architect

Wikipedia

Frederick Walters

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Frederick Arthur Walters (18491931) was a Scottish architect working in the Victorian and Edwardian eras, notable for his Roman Catholic churches. ...

Medicine Doctors

Frederick P. Walters

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Specialties:

Urology

Work:

South County Urological
12345 W Bnd Dr STE 200, Saint Louis, MO 63128
3148438000 (phone), 3148433004 (fax)

Education:

Medical School
Saint Louis University School of Medicine
Graduated: 1987

Procedures:

Bladder Repair
Circumcision
Cystoscopy
Cystourethroscopy
Kidney Stone Lithotripsy
Nephrectomy
Prostate Biopsy
Transurethral Resection of Prostate
Urinary Flow Tests
Vaginal Repair
Vasectomy

Conditions:

Bladder Cancer
Prostate Cancer
Prostatitis
Urinary Tract Infection (UT)
Benign Prostatic Hypertrophy

Languages:

English

Description:

Dr. Walters graduated from the Saint Louis University School of Medicine in 1987. He works in Saint Louis, MO and specializes in Urology. Dr. Walters is affiliated with Saint Anthonys Medical Center.

Frederick C. Walters

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Specialties:

Pediatrics

Work:

Bainbridge Pediatrics
9431 Coppertop Loop NE STE 101, Bainbridge Island, WA 98110
2067805437 (phone), 2067805438 (fax)

Education:

Medical School
University of California, San Francisco School of Medicine
Graduated: 1999

Procedures:

Circumcision
Destruction of Benign/Premalignant Skin Lesions
Electrocardiogram (EKG or ECG)
Hearing Evaluation
Psychological and Neuropsychological Tests
Vaccine Administration

Conditions:

Acute Pharyngitis
Acute Sinusitis
Acute Upper Respiratory Tract Infections
Anxiety Phobic Disorders
Attention Deficit Disorder (ADD)

Languages:

English

Description:

Dr. Walters graduated from the University of California, San Francisco School of Medicine in 1999. He works in Bainbridge Island, WA and specializes in Pediatrics.