Leigh H. English - Churchville PA Susan M. Brussock - New Hope PA Thomas M. Malvar - St. Louis MO James W. Bryson - Langhorne PA Caroline A. Kulesza - Charlottesville VA Frederick S. Walters - Beaver Falls PA Stephen L. Slatin - Fair Lawn NJ Michael A. Von Tersch - Ewing Township NJ Charles Romano - Ballwin MO
Assignee:
Monsanto Technology, LLC - St. Louis MO
International Classification:
A01H 500
US Classification:
800302, 800279
Abstract:
Disclosed are nucleic acid segments comprising synthetically-modified genes encoding modified Coleopteran-toxic Cry 3Bb* -endotoxins. Also disclosed are methods of using these genes for preparing a Coleopteran-resistant transgenic plant and reducing insect in restations, and plants thereby produced.
Leigh H. English - Churchville PA Susan M. Brussock - New Hope PA Thomas M. Malvar - St. Louis MO James W. Bryson - Langhorne PA Caroline A. Kulesza - Charlottesville VA Frederick S. Walters - Beaver Falls PA Stephen L. Slatin - Fair Lawn NJ Michael A. Von Tersch - Ewing Township NJ Charles Romano - Ballwin MO
Disclosed are nucleic acid segments comprising synthetically-modified genes encoding Coleopteran-toxic -endotoxins. Also disclosed are methods of using these genes for the recombinant expression of polypeptides, the preparation of vectors containing the genes, and methods for transforming suitable host cells.
Leigh H. English - Chesterfield MO, US Susan M. Brussock - New Hope PA, US Thomas M. Malvar - Troy MO, US James W. Bryson - Langhorne PA, US Caroline A. Kulesza - Cranbury NJ, US Frederick S. Walters - Raleigh NC, US Stephen L. Slatin - New York NY, US Michael A. Von Tersch - Trenton NJ, US Charles Romano - Chesterfield MO, US
Assignee:
Monsanto Technology LLC - St. Louis MO
International Classification:
A01H 5/00 A01H 5/10 C12N 15/82 C12N 1/21
US Classification:
800302, 4352523, 435418, 800279
Abstract:
The invention provides transgenic plants and transformed host cells which express modified cry 3B genes with enhanced toxicity to Coleopteran insects. Also disclosed are methods of making and using these transgenic plants, methods of making recombinant host cells expressing these δ-endotoxins, and methods of killing insects such as Colorado potato beetle (Leptinotarsa decemlineata), southern corn rootworm (Diabrotica undecimpunctata howardi Barber) and western corn rootworm (Diabrotica virgifera virgifera LeConte.
Coleopteran-Resistant Transgenic Plants And Methods Of Their Production
Leigh H. English - Churchville PA, US Susan M. Brussock - New Hope PA, US Thomas M. Malvar - St. Louis MO, US James W. Bryson - Langhorne PA, US Caroline A. Kulesza - Charlottesville VA, US Frederick S. Walters - Beaver Falls PA, US Stephen L. Slatin - Fair Lawn NJ, US Michael A. Von Tersch - Ewing Township NJ, US Charles Romano - Ballwin MO, US
Assignee:
Monsanto Technology LLC - St. Louis MO
International Classification:
C12N 15/82 A01H 5/00 A01H 5/10
US Classification:
800302, 800279
Abstract:
Disclosed are nucleic acid segments comprising synthetically-modified genes encoding Coleopteran-toxic δ-endotoxins. Also disclosed are methods of using these genes for the recombinant expression of polypeptides, the preparation of vectors containing the genes, and methods for transforming suitable host cells.
Coleopteran-Resistant Transgenic Plants And Methods Of Their Production
Leigh H. English - Churchville PA, US Susan M. Brussock - New Hope PA, US Thomas M. Malvar - St. Louis MO, US James W. Bryson - Langhorne PA, US Caroline A. Kulesza - Charlottesville VA, US Frederick S. Walters - Beaver Falls PA, US Stephen L. Slatin - Fair Lawn NJ, US Michael A. Von Tersch - Ewing Township NJ, US Charles Romano - Ballwin MO, US
Assignee:
Monsanto Technology LLC - St. Louis MO
International Classification:
A01H 5/00 A01H 5/10 C12N 15/82
US Classification:
800302, 800279
Abstract:
Disclosed are nucleic acid segments comprising synthetically-modified genes encoding Coleopteran-toxic δ-endotoxins. Also disclosed are methods of using these genes for the recombinant expression of polypeptides, the preparation of vectors containing the genes, and methods for transforming suitable host cells.
Hope Hart - Research Triangle Park NC, US Jeng S. Chen - Research Triangle Park NC, US Cheryl Stacy - Research Triangle Park NC, US Frederick Walters - Research Triangle Park NC, US
Assignee:
Syngenta Participations AG - Basel
International Classification:
C07K 14/325
US Classification:
514 45
Abstract:
Compositions and methods for controlling plant pests are disclosed. In particular, novel engineered hybrid insecticidal proteins (eHIPs) having toxicity to at least corn rootworm are provided. By fusing unique combinations of complete or partial variable regions and conserved blocks of at least two different (Bt) Cry proteins or a modified Cry proteins an eHIP having activity against corn rootworm is designed. Nucleic acid molecules encoding the novel eHIPs are also provided. Methods of making the eHIPs and methods of using the eHIPs and nucleic acids encoding the eHIPs of the invention, for example in transgenic plants to confer protection from insect damage are also disclosed.
Coleopteran-Resistant Transgenic Plants And Methods Of Their Production
Leigh H. English - Churchville PA, US Susan M. Brussock - New Hope PA, US Thomas M. Malvar - St. Louis MO, US James W. Bryson - Langhorne PA, US Caroline A. Kulesza - Charlottesville VA, US Frederick S. Walters - Beaver Falls PA, US Stephen L. Slatin - Fair Lawn NJ, US Michael A. Von Tersch - Ewing Township NJ, US Charles Romano - Ballwin MO, US
Assignee:
Monsanto Technology LLC - St. Louis MO
International Classification:
A01H 5/00 A01H 5/10 C12N 15/82
US Classification:
800302, 800279
Abstract:
Disclosed are nucleic acid segments comprising synthetically-modified genes encoding Coleopteran-toxic δ-endotoxins. Also disclosed are methods of using these genes for the recombinant expression of polypeptides, the preparation of vectors containing the genes, and methods for transforming suitable host cells.
Modified Cry3A Toxins And Nucleic Acid Sequences Coding Therefor
Compositions and methods for controlling plant pests are disclosed. In particular, novel nucleic acid sequences encoding modified Cry3A toxins having increased toxicity to corn rootworm are provided. By inserting a protease recognition site that is recognized by a gut protease of a target insect in at least one position of a Cry3A toxin a modified Cry3A toxin having significantly greater toxicity, particularly to western and northern corn rootworm is designed. Further, a method of making the modified Cry3A toxins and methods of using the modified cry3A nucleic acid sequences, for example in microorganisms to control insects or in transgenic plants to confer protection from insect damage, and a method of using the modified Cry3A toxins, and compositions and formulations comprising the modified Cry3A toxins, for example applying the modified Cry3A toxins or compositions or formulations to insect-infested areas, or to prophylactically treat insect-susceptible areas or plants to confer protection against the insect pests are disclosed.
Bladder Cancer Prostate Cancer Prostatitis Urinary Tract Infection (UT) Benign Prostatic Hypertrophy
Languages:
English
Description:
Dr. Walters graduated from the Saint Louis University School of Medicine in 1987. He works in Saint Louis, MO and specializes in Urology. Dr. Walters is affiliated with Saint Anthonys Medical Center.
Dr. Walters graduated from the University of California, San Francisco School of Medicine in 1999. He works in Bainbridge Island, WA and specializes in Pediatrics.