Gang Yun L Liu

US Patent:

8149397, Apr 3, 2012

Filed:

Mar 14, 2006

Appl. No.:

11/886390

Inventors:

Luke P. Lee - Orinda CA, US
Yu Lu - Riverside CA, US
Gang L. Liu - Berkeley CA, US
Jaeyoun Kim - Ames IA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01J 3/44

US Classification:

356301

Abstract:

The disclosure relates to metallic nanophotonic crescent structures, or “nanocrescent SERS probes,” that enhance detectable signals to facilitate molecular detections. More particularly, the nanocrescent SERS probes of the disclosure possess specialized geometries, including an edge surrounding the opening that is capable of enhancing local electromagnetic fields. Nanosystems utilizing such structures are particularly useful in the medical field for detecting rare molecular targets, biomolecular cellular imaging, and in molecular medicine.

US Patent:

8361932, Jan 29, 2013

Filed:

May 2, 2007

Appl. No.:

12/299284

Inventors:

Gang L. Liu - Berkeley CA, US
Jonathan A. Ellman - Oakland CA, US
Luke P. Lee - Orinda CA, US
Fanqing Frank Chen - Moraga CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C40B 30/04
C40B 40/10
G01N 33/573

US Classification:

506 9, 435 74, 506 18

Abstract:

This invention pertains to the in vitro detection of proteases using a single peptide-conjugate nanocrescent surface enhanced Raman scattering (SERS) probes with at least nanomolar sensitivity. The probe enables detection of proteolytic activity in extremely small volume and at low concentration. In certain embodiments the probes comprise an indicator for the detection of an active protease, where the indicator comprises a nanocrescent attached to a peptide, where said peptide comprises a recognition site for the protease and a Raman tag attached to the peptide.

US Patent:

8497637, Jul 30, 2013

Filed:

Apr 13, 2011

Appl. No.:

13/066388

Inventors:

Gang Gary Liu - Plano TX, US

International Classification:

H05B 37/02
H05B 39/04
H05B 41/36
F02P 3/08

US Classification:

315225, 315209 CD, 315172

Abstract:

A constant voltage dimmable LED (Light Emitting Diode) driver is disclosed that is compatible with all types of dimmers, including conventional phase cut (TRIAC) dimmers, and behaves like a conventional constant voltage driver which can be connected to any size of LED load that has a matching voltage rating. The driver produces a continuous train of pulses for driving the LED load and obtains an averaged measure of the voltage at the AC input for controlling the duty cycle of the continuous train of pulses. Therefore, when the averaged measure of the voltage at the AC input is reduced by a dimmer, the duty cycle reduces, resulting in a dimmed LED. The driver can be created by adding a few components to a conventional wide input range AC-DC converter without or with very little modifications.

US Patent:

8569468, Oct 29, 2013

Filed:

Sep 14, 2007

Appl. No.:

12/440579

Inventors:

Fanqing Frank Chen - Moraga CA, US
Gang L. Liu - Berkeley CA, US
Luke P. Lee - Orinda CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12Q 1/68

US Classification:

536 231, 977773, 977762

Abstract:

This invention provides a nanoplasmonic molecular ruler, which can perform label-free and real-time monitoring of nucleic acid (e. g. , DNA) length changes and perform nucleic acid footprinting. In various embodiments the ruler comprises a nucleic acid attached to a nanoparticle, such that changes in the nucleic acid length are detectable using surface plasmon resonance. The nanoplasmonic ruler provides a fast and convenient platform for mapping nucleic acid-protein interactions, for nuclease activity monitoring, and for other footprinting related methods.

US Patent:

20090121273, May 14, 2009

Filed:

Sep 22, 2005

Appl. No.:

11/664018

Inventors:

Gang Liu - Fremont CA, US
Min She - Fremont CA, US

International Classification:

H01L 29/68
H01L 29/788

US Classification:

257316, 257E2917, 257E293

Abstract:

In a non-volatile semiconductor memory device including a source region separated from a drain region by a channel region and with an electrically floating gate electrode spaced from and overlying the channel region, a flexible member is spaced from the floating gate and capable of being flexed towards the floating gate for depositing or removing electrical charge on the floating gate in response to a voltage potential between the flexible member and the channel region. In one embodiment, the flexible member comprises a contact gate electrode. In another embodiment, only a single gate electrode is employed without a separate floating gate.

US Patent:

20100196920, Aug 5, 2010

Filed:

May 9, 2008

Appl. No.:

12/599639

Inventors:

Luke P. Lee - Orinda CA, US
Gang L. Liu - Champaign IL, US
Yitao Long - Shanghai, CN

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

G01N 33/53
G01N 33/543

US Classification:

435 71, 436518, 977773, 977904

Abstract:

The disclosure provides methods and compositions useful for measuring a target analyte in a sample with nanoparticle plasmon resonance. In particular the disclosure provides methods and compositions for measuring a target analyte comprising plasmon resonance energy transfer.

US Patent:

20110046018, Feb 24, 2011

Filed:

Dec 23, 2008

Appl. No.:

12/746158

Inventors:

Fanqing Frank Chen - Moraga CA, US
Gang L. Liu - Berkeley CA, US
Jonathan A. Ellman - Oakland CA, US

International Classification:

C40B 50/14
C12M 1/34
C12Q 1/48
C12Q 1/42
B44C 1/22

US Classification:

506 30, 4352887, 435 15, 435 21, 216 24

Abstract:

This invention provides novel compositions and methods for the detection, and/or quantification, of the presence and/or activity of one or more kinases and/or phosphatases. In certain embodiments this invention a device for the detection of kinase and/or phosphatase activity where the device comprises a Raman active surface comprising features that enhance Raman scattering having attached thereto a plurality of kinase and/or phosphatase substrate molecules.

US Patent:

20130300303, Nov 14, 2013

Filed:

Jul 17, 2013

Appl. No.:

13/944611

Inventors:

Gang Gary Liu - Plano TX, US

International Classification:

H05B 33/08

US Classification:

315200 R

Abstract:

A constant voltage dimmable LED (Light Emitting Diode) driver is disclosed that is compatible with all types of dimmers, including conventional phase cut (TRIAC) dimmers, and behaves like a conventional constant voltage driver which can be connected to any size of LED load that has a matching voltage rating. The driver produces a continuous train of pulses for driving the LED load and obtains an averaged measure of the voltage at the AC input for controlling the duty cycle of the continuous train of pulses. Therefore, when the averaged measure of the voltage at the AC input is reduced by a dimmer, the duty cycle reduces, resulting in a dimmed LED. The driver can be created by adding a few components to a conventional wide input range AC-DC converter without or with very little modifications.