Gang Han L Liu

US Patent:

6353109, Mar 5, 2002

Filed:

Jun 1, 1998

Appl. No.:

09/088522

Inventors:

Pamela Albaugh - Clinton CT
Gang Liu - Branford CT
Alan Hutchison - Madison CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07C23359

US Classification:

5462774, 5462777, 5462781, 548492, 548504, 548512, 548516, 564163, 564169, 564172, 564180, 564189

Abstract:

Disclosed are compounds of the formula or the pharmaceutically acceptable non-toxic salts thereof wherein: W represents substituted or unsubstituted aryl or heteroaryl; T is hydrogen, halogen, hydroxyl, amino or alkyl; X is hydrogen, hydroxy, or lower alkyl; m is 0, 1, or 2; n is 0, 1, or 2; and R and R represent substituted or unsubstituted organic residues. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.

US Patent:

6380209, Apr 30, 2002

Filed:

May 30, 2000

Appl. No.:

09/583147

Inventors:

Guolin Cai - Guilford CT
Gang Liu - Agoura CA

Assignee:

Neurogen Corporation - Branford CT

International Classification:

A61K 314375

US Classification:

514300, 514301, 514258, 514249, 514248, 544236, 544279, 544350, 546114, 546122

Abstract:

Disclosed are compounds of the formula or the pharmaceutically acceptable non-toxic salts thereof wherein: R is hydrogen, alkyl, or(un)substituted alkoxy or amino; and W is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. The compounds of the invention are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.

US Patent:

6399604, Jun 4, 2002

Filed:

Aug 8, 2000

Appl. No.:

09/634093

Inventors:

Pamela A. Albaugh - Clinton CT
Robert W. DeSimone - Durham CT
Gang Liu - Agoura CA

Assignee:

Neurogen Corporation - Branford CT

International Classification:

A61K 31535

US Classification:

5142352, 514300, 544128, 546123

Abstract:

The present invention encompasses structures of the Formula or the pharmaceutically acceptable non-toxic salts thereof wherein: X is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; and Y is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.

US Patent:

6423711, Jul 23, 2002

Filed:

Dec 13, 2000

Appl. No.:

09/736497

Inventors:

Guolin Cai - Guilford CT
Gang Liu - Agoura CA
Guoquing Chen - North Branford CT
Pamela A. Albaugh - Clinton CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D41304

US Classification:

5142338, 51425304, 514301, 544127, 544362, 546114

Abstract:

Disclosed are compounds of the formula or the pharmaceutically acceptable non-toxic salts thereof wherein: n is an integer from 0 to 3; the C ring is aryl or heteroaryl; X is CH, N, or O Z represents an electron pair, hydrogen, or (un)substituted heterocycle, aryl, or amido; W is (un)substituted alkyl, aryl, or heteroaryl; A and B are hydrogen or lower alkyl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.

US Patent:

6448246, Sep 10, 2002

Filed:

May 25, 2000

Appl. No.:

09/578928

Inventors:

Guolin Cai - Guilford CT
Gang Liu - Agoura CA
Pamela A. Albaugh - Clinton CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D27916

US Classification:

5142242, 544 51, 544 52

Abstract:

Disclosed are 4H-1,4-Benzothiazine-2-carboxamides. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, depression, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Compounds of the invention are also useful as probes for the localization of GABAA receptors in tissue samples.

US Patent:

6515140, Feb 4, 2003

Filed:

Mar 8, 2001

Appl. No.:

09/801956

Inventors:

Pamela Albaugh - Clinton CT
Gang Liu - Agoura CA
Kenneth Shaw - Weston CT
Alan Hutchison - Madison CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D40312

US Classification:

548455, 548454, 544105

Abstract:

Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein: G, X, T, n, and R -R are as defined herein, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.

US Patent:

6645990, Nov 11, 2003

Filed:

Feb 15, 2002

Appl. No.:

10/077124

Inventors:

Benny C. Askew - Newbury Park CA
Frenel F. De Morin - Thousand Oaks CA
Andrew Hague - Camarillo CA
Ellen Laber - Ventura CA
Aiwen Li - Westlake Village CA
Gang Liu - Oak Park CA
Patricia Lopez - Northridge CA
Rana Nomak - Westlake Village CA
Vincent Santora - Ladera Ranch CA
Christopher Tegley - Thousand Oaks CA
Kevin Yang - San Gabriel CA

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D21126

US Classification:

514342, 514241, 514247, 514256, 514315, 544162, 544180, 544182, 544224, 544333, 546229, 5462687

Abstract:

Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

6646124, Nov 11, 2003

Filed:

Apr 2, 2002

Appl. No.:

10/114743

Inventors:

Pamela A. Albaugh - Carmel IN
Robert W. DeSimone - Durham CT
Gang Liu - Oak Park CA

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D41300

US Classification:

544128, 546123, 5142352, 514300

Abstract:

The present invention encompasses structures of the Formula or the pharmaceutically acceptable non-toxic salts thereof wherein: X is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; and Y is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.