Joseph William Epstein - Monroe NY Gary H. Birnberg - Tuxedo Park NY Edward James Salaski - Tenafly NJ Gloria Jean Macewan - Monroe NY Katherine Cheung - Paramus NJ
Assignee:
Wyeth Holdings Corporation - Madison NJ
International Classification:
A61K 31425
US Classification:
514369, 514314, 514342
Abstract:
This invention relates to a method of using novel 5-(arylsulfonyl)-5-(arylsulfinyl)- and 5-(arylsulfanyl)thiazolidine-2,4-diones of Formula (I), wherein Ar, Arâ, R , m and n are as defined in the specification as inhibitors of Ras FPTase, and may be used as an alternative to, or in conjunction with, traditional cancer therapy for treating ras- oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid.
5-(Arylsulfonyl)-,5-(Arylsulfinyl), And 5-(Arylsulfanyl)-Thiazolidine-2,4-Diones Useful For Inhibition Of Farnesyl-Protein Transferase
Joseph William Epstein - Monroe NY Gary Harold Birnberg - Tuxedo Park NY Edward James Salaski - Tenafly NJ Gloria Jean Macewan - Monroe NY Katherine Cheung - Paramus NJ
This invention relates to a method of using novel 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones of Formula (I), wherein Ar, Arâ, R , m and n are as defined in the specification as inhibitors of Ras FPTase, and may be used as an alternative to, or in conjunction with, traditional cancer therapy for treating ras-oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid.
Method For The Regioselective Preparation Of Substituted Benzo[G]Quinoline-3-Carbonitriles And Benzo[G]Quinazolines
This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.
Arie Zask - New York NY, US Joshua Kaplan - Nyack NY, US Ayako Yamashita - Englewood NJ, US Chuan S. Niu - Cheshire CT, US Gary Harold Birnberg - Tuxedo Park NY, US Emily Norton - Nanuet NY, US Kinwang Cheung - Harrington Park NJ, US Ronald Suayan - Waldwick NJ, US Vincent Sandanayaka - Northboro MA, US Philip Ross Hamann - Thiells NY, US
Arie Zask - New York NY, US Joshua Kaplan - Nyack NY, US Ayako Yamashita - Englewood NJ, US Chuan S. Niu - Cheshire CT, US Gary Harold Birnberg - Tuxedo Park NY, US Emily Norton - Nanuet NY, US Kinwang Cheung - Harrington Park NJ, US Ronald Suayan - Waldwick NJ, US Vincent Sandanayaka - Northboro MA, US Philip Ross Hamann - Thiells NY, US
Assignee:
Wyeth - Madison NJ
International Classification:
C07D 241/02 A61K 31/495
US Classification:
544386, 51425501
Abstract:
The invention provides compounds of formula (I):.
Substituted Isoquinoline-1,3(2,4)-Diones, 1-Thioxo,1,4-Dihydro-2-Isoquinoline-3-Ones And 1,4-Dihyro-3 (2)-Isoquinolones And Methods Of Use Thereof
Gary Harold Birnberg - Tuxedo Park NY, US Middleton Brawner Floyd - Suffern NY, US Joshua Kaplan - Nyack NY, US Kristina M. Kutterer - Westwood NJ, US Xiaoxiang Liu - River Vale NJ, US Ramaswamy Nilakantan - Closter NJ, US Mercy Adufa Otteng - Pearl River NY, US Zhilian Tang - Edgewater NJ, US Arie Zask - New York NY, US Tritin Tran - King of Prussia PA, US Scott Christian Mayer - Bridgewater NJ, US Annette L. Banker - Plainsboro NJ, US Marvin Reich - Santa Fe NM, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
A61K 31/47 C07D 217/08
US Classification:
514309, 546142
Abstract:
This invention provides compounds of Formula (I), having the structure.
Method For The Regioselective Preparation Of Substituted Benzo[G]Quinoline3-Carbonitriles And Benzo[G]Quinazolines
This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.
Method For The Regioselective Preparation Of Substituted Benzo[G]Quinoline-3-Carbonitriles And Benzo[G]Quinazolines
Dan Maarten Berger - New City NY, US Gary Harold Birnberg - Tuxedo Park NY, US Yanyong Wang - Nanuet NY, US
Assignee:
Wyeth - Madison NJ
International Classification:
C07D 239/70 C07D 221/06
US Classification:
544249, 546110
Abstract:
This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.
Gary Birnberg's Public Profile on Plaxo. Plaxo helps members like Gary Birnberg keep in touch with the people who really matter, helping them to connect, keep each other's contact ...