Gregory Scott Wilson

US Patent:

48165638, Mar 28, 1989

Filed:

Nov 15, 1984

Appl. No.:

6/670596

Inventors:

Gregory B. Wilson - Mount Pleasant SC
Gary V. Paddock - Mount Pleasant SC

Assignee:

Amtron, Inc. - Charleston SC

International Classification:

A61K 3900
A61K 3902
A61K 3912
C07H 1512

US Classification:

530344

Abstract:

Antigen specific excreted transfer factor may be obtained by collecting material, e. g. colostrum or milk, secreted by the mammary gland of a suitable lactating mammal, e. g. a cow having immunity to the antigen under suitable conditions such that materials which interfere with transfer factor efficacy are removed so as to obtain transfer factor. Colostrum or milk so collected may be used directly, typically after sterilization, or may be treated to further concentrate and/or purify transfer factor. Treatment to yield colostral whey containing transfer factor is presently the preferred method for obtaining transfer factor for use in conferring immunity against diseases associated with antigens for which the transfer factor is specific. Cell-associated transfer factor specific for an antigen may also be obtained by incubation release from, or lysis of, cells obtained from the collected material. An alternative method for obtaining transfer factor is to recover it from the mammary tissue of a suitable lactating mammal.

US Patent:

43222749, Mar 30, 1982

Filed:

Aug 28, 1980

Appl. No.:

6/182007

Inventors:

Gregory B. Wilson - Isle of Palms SC
H. Hugh Fudenberg - Isle of Palms SC

International Classification:

G01N 2726
G01N 3316

US Classification:

204180G

Abstract:

An immunologic method has been devised enabling diagnosis of patients with cystic fibrosis, as well as asymptomatic carriers of the cystic fibrosis gene. Mono-specific antibody to Cystic Fibrosis Protein (CFP) is inserted into a first position on an electrophoresis plate. A body fluid from the subject to be tested is placed into a second position on the plate. An electrical potential is imposed across the positions with the anode being adjacent to the section containing the serum and the cathode being adjacent to the section containing the antibody. The presence of Cystic Fibrosis Protein is indicated by one or more precipitation zones forming where the body fluid proteins meet the antibody due to movement induced by an applied electrical potential. The relative position of the precipitation zone between the first and second positions, or the area of the precipitation zone, indicates a concentration of the Cystic Fibrosis Protein. Methods for producing the purified Cystic Fibrosis Protein antibody and for purifying the Cystic Fibrosis Protein itself are also disclosed.