Hao Cheng Liu

US Patent:

6593087, Jul 15, 2003

Filed:

Dec 27, 2000

Appl. No.:

09/749340

Inventors:

Roger K. Prichard - Beaconsfield, CA
Ming Xu - Chino CA
Ana Paula Ribeiro - Montreal, CA
William J. Blackhall - Pointe Claire, CA
Robin N. Beech - Beaconsfield, CA
Marcelo Molento - Sainte-Anne-de-Bellevue, CA
Hao Yuan Liu - Newton MA

Assignee:

McGill University - Montreal

International Classification:

C12Q 168

US Classification:

435 6, 435 29, 435243, 435245, 514 30, 514 65, 514 89, 424405, 424422, 424424, 424426

Abstract:

This invention describes novel purified and isolated nucleic acid molecules or the fragments thereof, extracted from nematode or arthropod pests or recombinant, which encode P-glycoprotein homologs and regulate resistance to the macrocyclic lactone compounds. The invention further relates to the new P-glycoprotein homolog expression product of these nucleic acids. Also described herein are methods for detecting the gene encoding for resistance to the macrocyclic lactone compounds in nematode or arthropod pests which comprise comparing the nucleic acids extracted from a pest specimen to the nucleic acids encoding for resistance and the nucleic acids encoding for susceptibility to the macrocyclic lactone compounds. Lastly, the present invention is also drawn to methods and compositions for increasing the efficacy of the macrocyclic lactone compounds against resistant nematode or resistant arthropod pests which comprise administering to a mammal or applying to crops and the like a pesticidal enhancing effective amount of a multidrug resistance reversing agent.

US Patent:

7358053, Apr 15, 2008

Filed:

Jun 6, 2003

Appl. No.:

10/456815

Inventors:

Roger K. Prichard - Beaconsfield, CA
Ming Xu - Chino CA, US
Ana Paula Ribeiro - Montreal, CA
William J. Blackhall - Pointe Claire, CA
Robin N. Beech - Beaconsfield, CA
Marcelo Molento - Sainte-Anne-de-Bellevue, CA
Hao Yuan Liu - Newton MA, US

Assignee:

McGill Univeristy - Montreal, Quebec

International Classification:

G01N 33/53

US Classification:

435 71, 436547

Abstract:

This invention describes novel purified and isolated nucleic acid molecules or the fragments thereof, extracted from nematode or arthropod pests or recombinant, which encode P-glycoprotein homologs and regulate resistance to the macrocyclic lactone compounds. The invention further relates to the new P-glycoprotein homolog expression product of these nucleic acids. Also described herein are methods for detecting the gene encoding for resistance to the macrocyclic lactone compounds in nematode or arthropod pests which comprise comparing the nucleic acids extracted from a pest specimen to the nucleic acids encoding for resistance and the nucleic acids encoding for susceptibility to the macrocyclic lactone compounds. Lastly, the present invention is also drawn to methods and compositions for increasing the efficacy of the macrocyclic lactone compounds against resistant nematode or resistant arthropod pests which comprise administering to a mammal or applying to crops and the like a pesticidal enhancing effective amount of a multidrug resistance reversing agent.

US Patent:

7933283, Apr 26, 2011

Filed:

Mar 4, 2008

Appl. No.:

12/073317

Inventors:

Hao Howard Liu - Milpitas CA, US
Eugene W. Lee - San Jose CA, US

Assignee:

Cortina Systems, Inc. - Sunnyvale CA

International Classification:

H04L 12/54
G06F 15/167

US Classification:

370412, 370428, 709213

Abstract:

Shared memory management apparatus and techniques are disclosed. A shared memory provides queues for storing communication traffic that is to be scheduled for transmission. Based on amounts of communication traffic stored in the queues, a determination is made as to whether or not communication traffic is to be removed from the shared memory, and if so, communication traffic is removed. Traffic may be selected for removal based on one or more of: a scheduling algorithm for scheduling communication traffic out of the queues for transmission, thresholds associated with the queues, and latency of the communication traffic stored in the queues. Removal of communication traffic from the shared memory is coordinated with scheduling of communication traffic in some embodiments.

US Patent:

6403308, Jun 11, 2002

Filed:

Apr 28, 1998

Appl. No.:

09/067676

Inventors:

Roger K. Prichard - Beaconsfield, CA
Ming Xu - Chino CA
Ana Paula Ribeiro - Montreal, CA
William J. Blackhall - Pointe Claire, CA
Robin N. Beech - Beaconsfield, CA
Marcelo Molento - Sainte-Anne-de-Bellevue, CA
Hao Yuan Liu - Newton MA

Assignee:

McGill University - Montreal

International Classification:

C12Q 168

US Classification:

435 6, 536 221

Abstract:

This invention describes novel purified and isolated nucleic acid molecules or the fragments thereof, extracted from nematode or arthropod pests or recombinant, which encode P-glycoprotein homologs and regulate resistance to the macrocyclic lactone compounds. The invention further relates to the new P-glycoprotein homolog expression product of these nucleic acids. Also described herein are methods for detecting the gene encoding for resistance to the macrocyclic lactone compounds in nematode or arthropod pests which comprise comparing the nucleic acids extracted from a pest specimen to the nucleic acids encoding for resistance and the nucleic acids encoding for susceptibility to the macrocyclic lactone compounds. Lastly, the present invention is also drawn to methods and compositions for increasing the efficacy of the macrocyclic lactone compounds against resistant nematode or resistant arthropod pests which comprise administering to a mammal or applying to crops and the like a pesticidal enhancing effective amount of a multidrug resistance reversing agent.

US Patent:

20210381819, Dec 9, 2021

Filed:

Nov 6, 2019

Appl. No.:

17/287061

Inventors:

- Oakland CA, US
Chee Wei Wong - Los Angeles CA, US
Hao Liu - Los Angeles CA, US
Jinghui Yang - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01B 9/02
G02F 1/365
H01S 3/067
G01S 17/36
G01S 7/484

Abstract:

Systems and methods for soliton microcomb-based precision dimensional metrology via spectrally-resolved interferometry are described. In an embodiment, the system includes a dual-pumped soliton microcomb generator comprising a pump, a microresonator, and an auxiliary pump and that generates a single-soliton microcomb, an erbium-doped fiber amplifier that amplifies a C-band section of the soliton microcomb and a non-polarizing beam splitter that divides the soliton microcomb pulses into a reference arm pulse and a measurement arm pulse for an interferometer and recombines the reference arm pulse and the measurement arm pulse into a recombined beam upon their return.

US Patent:

20200234113, Jul 23, 2020

Filed:

Apr 25, 2019

Appl. No.:

16/395083

Inventors:

- San Francisco CA, US
Hao LIU - Palo Alto CA, US

International Classification:

G06N 3/08

Abstract:

A method for deep reinforcement learning using a neural network model includes receiving a distribution including a plurality of related tasks. Parameters for the reinforcement learning neural network model is trained based on gradient estimation associated with the parameters using samples associated with the plurality of related tasks. Control variates are incorporated into the gradient estimation by automatic differentiation.

US Patent:

20200175632, Jun 4, 2020

Filed:

Nov 30, 2018

Appl. No.:

16/207004

Inventors:

- San Francisco CA, US
Hao Yu Liu - Union City CA, US
Benjamin Han - San Francisco CA, US
Julia Yu - San Francisco CA, US
Le Guan - San Francisco CA, US
Xiaoyuan Xu - San Mateo CA, US
Mayank Gulati - San Francisco CA, US
Charles Parker Spielman - San Francisco CA, US
Chirag Chhagan Chheda - San Francisco CA, US
David Chouinard - San Francisco CA, US

International Classification:

G06Q 50/30
G06Q 10/06

Abstract:

The disclosed computer-implemented method may include dynamically selecting transportation options to present to a transportation requestor device based on current transportation network conditions and transportation requestor device history. In some embodiments, transportation network may have many different ways of arranging a transportation requestor's trip, such as private rides, shared rides, immediate rides, and delayed rides. In some examples, the requestor's choice of transportation option may have an impact on the transportation network. In anticipation of or in response to a transportation request, the method may determine which transportation options will better benefit the transportation network and determine which transportation options to display to the requestor and/or the prominence with which the transportation products are displayed. Various other methods, systems, and computer-readable media are also disclosed.

US Patent:

20200104404, Apr 2, 2020

Filed:

Sep 29, 2018

Appl. No.:

16/147737

Inventors:

- Redmond WA, US
Lanhui Long - Sunnyvale CA, US
Haochen Wei - Sunnyvale CA, US
Yiheng Wang - Sunnyvale CA, US
Hao Liu - Mountain View CA, US
Sourav Maji - Sunnyvale CA, US
Cindy Chen - Sunnyvale CA, US

International Classification:

G06F 17/30
H04L 29/08
G06F 9/54

Abstract:

Techniques for migrating clients from one technology stack to another are provided. In one technique, while a legacy service is hosted that is actively serving requests from multiple clients, a new service is initiated and one or more clients send requests to the new service. The legacy service reads data from and writes data to a legacy database in response to the requests. The new service forwards, to the legacy service, a first set of client requests that were directed to the new service. A new database is synchronized with the legacy database. After synchronization, the legacy service forwards, to the new service, a second set of client requests, which the new service processes.