Hao Jan Liu

US Patent:

6593087, Jul 15, 2003

Filed:

Dec 27, 2000

Appl. No.:

09/749340

Inventors:

Roger K. Prichard - Beaconsfield, CA
Ming Xu - Chino CA
Ana Paula Ribeiro - Montreal, CA
William J. Blackhall - Pointe Claire, CA
Robin N. Beech - Beaconsfield, CA
Marcelo Molento - Sainte-Anne-de-Bellevue, CA
Hao Yuan Liu - Newton MA

Assignee:

McGill University - Montreal

International Classification:

C12Q 168

US Classification:

435 6, 435 29, 435243, 435245, 514 30, 514 65, 514 89, 424405, 424422, 424424, 424426

Abstract:

This invention describes novel purified and isolated nucleic acid molecules or the fragments thereof, extracted from nematode or arthropod pests or recombinant, which encode P-glycoprotein homologs and regulate resistance to the macrocyclic lactone compounds. The invention further relates to the new P-glycoprotein homolog expression product of these nucleic acids. Also described herein are methods for detecting the gene encoding for resistance to the macrocyclic lactone compounds in nematode or arthropod pests which comprise comparing the nucleic acids extracted from a pest specimen to the nucleic acids encoding for resistance and the nucleic acids encoding for susceptibility to the macrocyclic lactone compounds. Lastly, the present invention is also drawn to methods and compositions for increasing the efficacy of the macrocyclic lactone compounds against resistant nematode or resistant arthropod pests which comprise administering to a mammal or applying to crops and the like a pesticidal enhancing effective amount of a multidrug resistance reversing agent.

US Patent:

7358053, Apr 15, 2008

Filed:

Jun 6, 2003

Appl. No.:

10/456815

Inventors:

Roger K. Prichard - Beaconsfield, CA
Ming Xu - Chino CA, US
Ana Paula Ribeiro - Montreal, CA
William J. Blackhall - Pointe Claire, CA
Robin N. Beech - Beaconsfield, CA
Marcelo Molento - Sainte-Anne-de-Bellevue, CA
Hao Yuan Liu - Newton MA, US

Assignee:

McGill Univeristy - Montreal, Quebec

International Classification:

G01N 33/53

US Classification:

435 71, 436547

Abstract:

This invention describes novel purified and isolated nucleic acid molecules or the fragments thereof, extracted from nematode or arthropod pests or recombinant, which encode P-glycoprotein homologs and regulate resistance to the macrocyclic lactone compounds. The invention further relates to the new P-glycoprotein homolog expression product of these nucleic acids. Also described herein are methods for detecting the gene encoding for resistance to the macrocyclic lactone compounds in nematode or arthropod pests which comprise comparing the nucleic acids extracted from a pest specimen to the nucleic acids encoding for resistance and the nucleic acids encoding for susceptibility to the macrocyclic lactone compounds. Lastly, the present invention is also drawn to methods and compositions for increasing the efficacy of the macrocyclic lactone compounds against resistant nematode or resistant arthropod pests which comprise administering to a mammal or applying to crops and the like a pesticidal enhancing effective amount of a multidrug resistance reversing agent.

US Patent:

7893746, Feb 22, 2011

Filed:

Oct 14, 2009

Appl. No.:

12/578895

Inventors:

Yuxiang Zheng - Richardson TX, US
Hao Liu - Dallas TX, US
Yanli Fan - Allen TX, US
Mark W. Morgan - Allen TX, US

Assignee:

Texas Instruments Incorporated - Dallas TX

International Classification:

H03H 11/26

US Classification:

327263, 327261, 327558

Abstract:

For differential signal transmission (especially in high speed applications), intra-pair skew between paths carrying complementary portions of a differential signal can significantly affect performance. Conventional de-skew circuits employ simple filters (i. e. , low-pass filters) to operate as delay elements to account for skew; however, these filters can distort the differential signal, which can also adverse affect performance. Here, an all-pass, adjustable delay element and de-skew circuit are provided to allow for compensation of skew without degrading the differential signal as conventional circuit do and, thus, having better performance characteristics.

US Patent:

7894517, Feb 22, 2011

Filed:

Nov 27, 2007

Appl. No.:

11/986900

Inventors:

Hao Liu - Richardson TX, US
Yanli Fan - Allen TX, US
Mark W. Morgan - Allen TX, US
Mohammed R. Islam - Richardson TX, US

Assignee:

Texas Instruments Incorporated - Dallas TX

International Classification:

H03H 7/30
H03H 7/40
H03K 5/159

US Classification:

375232, 375230, 375350, 708322, 708323

Abstract:

A self-calibrating, adaptive equalization system for generating an ideal digital signal is disclosed. The adaptive equalization system includes an equalizer and a high-gain buffer. The equalizer includes a first equalizer loop that feeds-back a control voltage to the equalizer and the high-gain buffer that includes a second equalizer loop that feeds-back a high-pass-to-low-pass filter ratio signal. Each of the first and second equalizer loops has a high-pass and a low-pass filter, rectifying circuits for each of the filters, and an integrating circuit that compares signal energy output from the rectifiers. The adaptive equalization system generates an ideal digital signal.

US Patent:

6403308, Jun 11, 2002

Filed:

Apr 28, 1998

Appl. No.:

09/067676

Inventors:

Roger K. Prichard - Beaconsfield, CA
Ming Xu - Chino CA
Ana Paula Ribeiro - Montreal, CA
William J. Blackhall - Pointe Claire, CA
Robin N. Beech - Beaconsfield, CA
Marcelo Molento - Sainte-Anne-de-Bellevue, CA
Hao Yuan Liu - Newton MA

Assignee:

McGill University - Montreal

International Classification:

C12Q 168

US Classification:

435 6, 536 221

Abstract:

This invention describes novel purified and isolated nucleic acid molecules or the fragments thereof, extracted from nematode or arthropod pests or recombinant, which encode P-glycoprotein homologs and regulate resistance to the macrocyclic lactone compounds. The invention further relates to the new P-glycoprotein homolog expression product of these nucleic acids. Also described herein are methods for detecting the gene encoding for resistance to the macrocyclic lactone compounds in nematode or arthropod pests which comprise comparing the nucleic acids extracted from a pest specimen to the nucleic acids encoding for resistance and the nucleic acids encoding for susceptibility to the macrocyclic lactone compounds. Lastly, the present invention is also drawn to methods and compositions for increasing the efficacy of the macrocyclic lactone compounds against resistant nematode or resistant arthropod pests which comprise administering to a mammal or applying to crops and the like a pesticidal enhancing effective amount of a multidrug resistance reversing agent.

US Patent:

20210381819, Dec 9, 2021

Filed:

Nov 6, 2019

Appl. No.:

17/287061

Inventors:

- Oakland CA, US
Chee Wei Wong - Los Angeles CA, US
Hao Liu - Los Angeles CA, US
Jinghui Yang - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01B 9/02
G02F 1/365
H01S 3/067
G01S 17/36
G01S 7/484

Abstract:

Systems and methods for soliton microcomb-based precision dimensional metrology via spectrally-resolved interferometry are described. In an embodiment, the system includes a dual-pumped soliton microcomb generator comprising a pump, a microresonator, and an auxiliary pump and that generates a single-soliton microcomb, an erbium-doped fiber amplifier that amplifies a C-band section of the soliton microcomb and a non-polarizing beam splitter that divides the soliton microcomb pulses into a reference arm pulse and a measurement arm pulse for an interferometer and recombines the reference arm pulse and the measurement arm pulse into a recombined beam upon their return.

US Patent:

20210288690, Sep 16, 2021

Filed:

May 27, 2021

Appl. No.:

17/331984

Inventors:

- Dallas TX, US
Wesley RAY - Frisco TX, US
Hao LIU - Dallas TX, US
Maxwell ROBERTSON - Dallas TX, US

International Classification:

H04B 3/54
H04L 27/04
H04L 5/16
H04B 1/69
H04L 27/00
H04L 27/06

Abstract:

Systems and methods are disclosed for an integrated circuit (IC) comprising an oscillator, an on-off-keying modulator configured to modulate input data coupled to the oscillator, a serial communications transmitter coupled to the on-off-keying modulator, a serial communications receiver coupled to the serial communications transmitter by a set of cables, and an envelope detector coupled to the serial communications receiver. In the IC, power and data are simultaneously delivered across the same set of cables from the serial communications transmitter to the serial communications receiver.

US Patent:

20190386703, Dec 19, 2019

Filed:

Jun 11, 2019

Appl. No.:

16/438165

Inventors:

- Dallas TX, US
Wesley RAY - Frisco TX, US
Hao LIU - Dallas TX, US
Maxwell ROBERTSON - Dallas TX, US

International Classification:

H04B 3/54
H04L 27/04
H04L 27/00
H04B 1/69
H04L 5/16

Abstract:

Systems and methods are disclosed for an integrated circuit (IC) comprising an oscillator, an on-off-keying modulator configured to modulate input data coupled to the oscillator, a serial communications transmitter coupled to the on-off-keying modulator, a serial communications receiver coupled to the serial communications transmitter by a set of cables, and an envelope detector coupled to the serial communications receiver. In the IC, power and data are simultaneously delivered across the same set of cables from the serial communications transmitter to the serial communications receiver.