Helen J Mcbride

US Patent:

20120231006, Sep 13, 2012

Filed:

Nov 19, 2010

Appl. No.:

13/510926

Inventors:

Hung Q. Nguyen - Camarillo CA, US
Fen-Fen Lin - Carlsbad CA, US
Xiao-juan Bi - Newbury Park CA, US
Helen J. McBride - Woodland Hills CA, US

Assignee:

Amgen Inc. - Thousands Oaks CA

International Classification:

A61K 39/395
C12N 15/13
C12N 15/63
C12N 5/10
C12P 21/02
C12N 5/16
A61P 37/00
A61P 3/10
A61P 19/02
A61P 1/00
A61P 29/00
A61P 37/08
A61P 1/16
A61P 35/00
A61P 31/04
A61P 9/10
C12N 1/21
C12N 1/19
C12N 1/15
C07K 16/18

US Classification:

4241391, 5303879, 5303873, 536 2353, 4353201, 435 696, 435331, 435 702, 43525233, 43525421, 43525411

Abstract:

Disclosed is an isolated antigen binding proteins, such as but not limited to, an antibody or antibody fragment, that specifically bind to SEQ ID NO: 4, the amino acid sequence of extracellular loop 2 (ECL2) of human Orai1. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors and host cells useful in methods of making it, and methods of using it in treating disorders or diseases in patients.