Helmut Kropp - Westfield NJ Daniel Farrington - Spearfish SD Jeffrey Clark - Middletown NJ Ronald Ratcliffe - Matawan NJ Robert Wilkening - Maplewood NJ
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A61K 3170
US Classification:
514 29
Abstract:
9a-Azalides, and pharmaceutical compositions containing them, are useful in the treatment and prevention of bacterial respiratory and enteric infections in livestock animals, particularly in cattle and swine.
Combination Of Thienamycin-Type Antibiotics With Dipeptidase Inhibitors
A novel antibacterial drug combination is provided, one component being a fused ring. beta. -lactam, such as thienamycin and its semi-synthetic derivatives, and the other component is a dipeptidase (E. C. 3. 4. 13. 11) inhibitor. The dual-component combination is formulated so that 1 to 3 parts by weight of the. beta. -lactam compound are employed for 30 to 1 parts by weight of the inhibitor compound.
Helmut Kropp - Westfield NJ Daniel O. Farrington - Spearfish SD Jeffrey N. Clark - Middletown NJ Ronald W. Ratcliffe - Matawan NJ Robert D. Wilkening - Maplewood NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3170
US Classification:
514 29
Abstract:
8a-Azalides are useful in the treatment and prevention of bacterial respiratory and enteric infections in livestock animals, particularly in cattle and swine.
Combination Of Thienamycin-Type Antibiotics With Dipeptidase Inhibitors
Helmut Kropp - Kenilworth NJ Frederick M. Kahan - Scotch Plains NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3124 A61K 3143 A61K 31195
US Classification:
514192
Abstract:
A novel antibacterial drug combination is provided, one component being a 2-substituted penem, and the other component is a dipeptidase (E. C. 3. 4. 13. 11) inhibitor. The dual-component combination is formulated so that 1 to 3 parts by weight of the penem are employed for 30 to 1 parts by weight of the inhibitor compound.
Combination Of 2-Substituted Carbapenems With Dipeptidase Inhibitors
A combination of a carbapenem of the formula: ##STR1## where R is H or CH. sub. 3 and R. sup. 1 is ##STR2## with a renal dipeptidase inhibitor is disclosed.
Use Of Substituted Propenoates To Prevent Nephrotoxicity Of Certain Antibiotics