Henry Wei

US Patent:

20050089868, Apr 28, 2005

Filed:

Sep 4, 2003

Appl. No.:

10/655506

Inventors:

Joseph Bonventre - Wayland MA, US
Catherine Hession - Hingham MA, US
Takaharu Ichimura - South Burlington VT, US
Henry Wei - Ossining NY, US
Richard Cate - Weston MA, US

International Classification:

C12Q001/68
C07H021/04
C07K014/705

US Classification:

435006000, 435069100, 435320100, 435325000, 530350000, 536023500

Abstract:

Proteins which are upregulated in injured or regenerating tissues, as well as the DNA encoding these proteins, are disclosed, as well as therapeutic compositions and methods of treatment encompassing these compounds.

US Patent:

20060286031, Dec 21, 2006

Filed:

Aug 8, 2006

Appl. No.:

11/463227

Inventors:

Joseph Bonventre - Wayland MA, US
Catherine Hession - Hingham MA, US
Takaharu Ichimura - South Burlington VT, US
Henry Wei - Ossining NY, US
Richard Cate - Weston MA, US

International Classification:

A61K 51/00
G01N 33/567
C07H 21/04
C12P 21/06
A61K 39/395
C07K 14/575

US Classification:

424001490, 536023400, 435069100, 435320100, 435325000, 530350000, 530388220, 530391100, 435328000, 435007200, 424178100

Abstract:

Proteins which are upregulated in injured or regenerating tissues, as well as the DNA encoding these proteins, are disclosed, as well as therapeutic compositions and methods of treatment encompassing these compounds.

US Patent:

20070141590, Jun 21, 2007

Filed:

Aug 8, 2006

Appl. No.:

11/463239

Inventors:

Joseph Bonventre - Wayland MA, US
Catherine Hession - Hingham MA, US
Takaharu Ichimura - South Burlington VT, US
Henry Wei - Ossining NY, US
Richard Cate - Weston MA, US

International Classification:

C12Q 1/68
G01N 33/567
C07H 21/04
C12P 21/06
C07K 14/705
C07K 16/28
A61K 51/00

US Classification:

435006000, 435069100, 435320100, 435325000, 435007200, 514012000, 530350000, 530388220, 536023500, 424001490

Abstract:

Proteins which are upregulated in injured or regenerating tissues, as well as the DNA encoding these proteins, are disclosed, as well as therapeutic compositions and methods of treatment encompassing these compounds.

US Patent:

6664385, Dec 16, 2003

Filed:

Nov 23, 1998

Appl. No.:

09/197970

Inventors:

Joseph V. Bonventre - Wayland MA
Catherine Hession - Hingham MA
Takaharu Ichimura - South Burlington VT
Henry Wei - Ossining NY
Richard L. Cate - Weston MA

Assignee:

Biogen, Inc. - Cambridge MA

International Classification:

C07H 2104

US Classification:

536 234, 536 235, 435 691, 435 697, 435325

Abstract:

Proteins which are upregulated in injured or regenerating tissues, as well as the DNA encoding these proteins, are disclosed, as well as therapeutic compositions and methods of treatment encompassing these compounds.

US Patent:

20210361227, Nov 25, 2021

Filed:

May 4, 2018

Appl. No.:

17/045318

Inventors:

- Mountain View CA, US
Michael Dwight Howell - Palo Alto CA, US
Kasumi Widner - San Carlos CA, US
Ryan Rifkin - Oakland CA, US
Henry George Wei - Larchmont NY, US
Daniel Ellis - New York NY, US
Alvin Rajkomar - Mountain View CA, US
Aren Jansen - Palo Alto CA, US
David Michael Parish - Buffalo NY, US
Michael Philip Brenner - Somerville MA, US

International Classification:

A61B 5/00
G10L 25/66
G10L 25/63
G06N 20/00

Abstract:

The present disclosure provides systems and methods that generating health diagnostic information from an audio recording. A computing system can include a machine-learned health model comprising that includes a sound model trained to receive data descriptive of a patient audio recording and output sound description data. The computing system can include a diagnostic model trained to receive the sound description data and output a diagnostic score. The computing system can include at least one tangible, non-transitory computer-readable medium that stores instructions that, when executed, cause the processor to perform operations. The operations can include obtaining the patient audio recording; inputting data descriptive of the patient audio recording into the sound model; receiving, as an output of the sound model, the sound description data; inputting the sound description data into the diagnostic model; and receiving, as an output of the diagnostic model, the diagnostic score.

US Patent:

20170116379, Apr 27, 2017

Filed:

Mar 25, 2016

Appl. No.:

15/081250

Inventors:

- Hartford CT, US
Henry George Wei - Larchmont NY, US
Michael Palmer - Boston MA, US

International Classification:

G06F 19/00
G06F 19/18

Abstract:

Optimization of therapeutic outcomes is disclosed. By analyzing molecular genomic sequence data from an individual relative to a pre-defined knowledge base as well as dynamically generated analyses from comparison to a set of other individuals and molecular genomic sequence data of those other individuals along with their therapeutic history and clinical outcome, medication selection for optimum therapeutic outcomes is achieved. The system determines likelihoods of the desired clinical outcome and adverse event profile derived from both the predefined knowledge base along with the dynamic analysis of large-scale population data (e.g., 1 million clinical profiles including linked genomes or some appropriate sample size of clinical profiles with linked genomes sufficient for statistically-powered analyses), and provides a set of recommendations and alternatives for a clinician based on the patient's profile. In certain instances, the system devises a therapeutic strategy of explicit absence of medical therapy for the purposes of cohort analysis.

US Patent:

20170004274, Jan 5, 2017

Filed:

Aug 30, 2016

Appl. No.:

15/252014

Inventors:

- Hartford CT, US
Henry George WEI - Larchmont NY, US
Gregory Brian STEINBERG - Dingmans Ferry PA, US

International Classification:

G06F 19/00
G06N 7/00

Abstract:

A method and system for analyzing a relationship between agents and clinical outcomes is disclosed. The method includes: receiving a selection of one or more agents; receiving a selection of one or more clinical outcomes; for each of the one or more agents, analyzing clinical data stored in a database to determine a number of occurrences of each of the one or more clinical outcomes when the agent is administered; for each of the one or more agents, calculating a risk score for each clinical outcome corresponding to the number of occurrences of the clinical outcome; and outputting the risk scores to a graphical display. The displayed information can also be scaled and filtered for ease of use. Also, the results may be stratified into sub-populations.

US Patent:

20170004275, Jan 5, 2017

Filed:

Aug 30, 2016

Appl. No.:

15/252026

Inventors:

- Hartford CT, US
Henry George WEI - Larchmont NY, US
Gregory Brian STEINBERG - Dingmans Ferry PA, US

International Classification:

G06F 19/00
G06N 7/00

Abstract:

A method and system for analyzing a relationship between agents and clinical outcomes is disclosed. The method includes: receiving a selection of one or more agents; receiving a selection of one or more clinical outcomes; for each of the one or more agents, analyzing clinical data stored in a database to determine a number of occurrences of each of the one or more clinical outcomes when the agent is administered; for each of the one or more agents, calculating a risk score for each clinical outcome corresponding to the number of occurrences of the clinical outcome; and outputting the risk scores to a graphical display. The displayed information can also be scaled and filtered for ease of use. Also, the results may be stratified into sub-populations.