Hilary A Rosenthal

US Patent:

20050013810, Jan 20, 2005

Filed:

May 8, 2002

Appl. No.:

10/477012

Inventors:

Edmund Waller - Atlanta GA, US
Hilary Rosenthal - Lilburn GA, US
Sagar Lonial - Atlanta GA, US

International Classification:

A61K039/395

US Classification:

424144100, 424093710

Abstract:

Disclosed within a method of altering immune responses using dendritic cells. One form of the method is a method of inducing immunological tolerance in an individual, where type 2 dendritic cells are administrated to an individual, and where the dendritic cells have been incubated with one or more antigens. Another form of the method involves altering an immune response, in which liposomes containing where liposomes containing one or more antigens are administrated to an individual, and where the liposomes are modified with surface-bound molecules that target the liposomes to type 2 dendritic cells. Another form of the method involves reducing immune responsiveness, where liposomes containing one or more antigens are administrated to an individual and where the liposomes are modified with the surface bound molecules that target the liposomes to type 1 dendritic cells or type 2 dendritic cells. Another form of the method is a method of enhancing immune responsiveness, where liposomes containing one or more antigens are administrated to an individual, and where the liposomes are modified with surface-bound molecules that target the liposomes to mature type 1 dendritic cells.