James E Ferrara

US Patent:

20200237708, Jul 30, 2020

Filed:

Apr 15, 2020

Appl. No.:

16/849879

Inventors:

- Atlanta GA, US
James Ferrara - Boulder CO, US
James D. McChesney - Etta MS, US

International Classification:

A61K 31/337
A61K 31/357
C07D 493/08
C07D 305/14
C07D 409/12

Abstract:

The present invention relates to a method for the treatment of cancer in a cancer patient. In particular, the invention provides a method for the treatment comprising administering a taxane compound to a cancer patient, wherein the taxane compound is made by a process comprising treating a first compound represented by either Formula G′ or Formula M′:with a second compound of generalized formula RRC(OCH)and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein Rand Rare each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; Ris an alkyl group, an olefinic group, or an aromatic group; Pis a hydroxyl protecting group; Pis H or an acid labile protecting group at the 7-O position; Ris H, alkyl group, olefinic or aromatic group; and Ris: H, alkyl group, olefinic or aromatic or is as defined in the specification.

US Patent:

20190142784, May 16, 2019

Filed:

Jan 14, 2019

Appl. No.:

16/247425

Inventors:

- Atlanta GA, US
James Ferrara - Boulder CO, US
James D. McChesney - Etta MS, US

International Classification:

A61K 31/337
C07D 409/12
A61K 31/357
C07D 305/14
C07D 493/08

Abstract:

Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G′ or Formula M′:with a second compound of generalized formula RRC(OCH)and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein Rand Rare each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; Ris an alkyl group, an olefinic group, or an aromatic group; Pis a hydroxyl protecting group; Pis H or an acid labile protecting group at the 7-O position; Ris H, alkyl group, olefinic or aromatic group; and Ris: H, alkyl group, olefinic or aromatic or is as defined in the specification.

US Patent:

20180125811, May 10, 2018

Filed:

Oct 9, 2017

Appl. No.:

15/728049

Inventors:

- Atlanta GA, US
James Ferrara - Boulder CO, US
James D. McChesney - Etta MS, US

International Classification:

A61K 31/337
C07D 493/08
C07D 409/12
C07D 305/14
A61K 31/357

Abstract:

Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G′ or Formula M′:with a second compound of generalized formula RRC(OCH)and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein Rand Rare each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; Ris an alkyl group, an olefinic group, or an aromatic group; Pis a hydroxyl protecting group; Pis H or an acid labile protecting group at the 7-O position; Ris H, alkyl group, olefinic or aromatic group; and Ris: H, alkyl group, olefinic or aromatic or is as defined in the specification.

US Patent:

20160331718, Nov 17, 2016

Filed:

Jul 27, 2016

Appl. No.:

15/220975

Inventors:

- Atlanta GA, US
James FERRARA - Boulder CO, US
James D. McCHESNEY - Etta MS, US

International Classification:

A61K 31/337
A61K 31/357

Abstract:

Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G′ or Formula M′:with a second compound of generalized formula RRC(OCH)and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein Rand Rare each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; Ris an alkyl group, an olefinic group, or an aromatic group; Pis a hydroxyl protecting group; Pis H or an acid labile protecting group at the 7-O position; Ris H, alkyl group, olefinic or aromatic group; and Ris: H, alkyl group, olefinic or aromatic or is as defined in the specification.

US Patent:

20150133536, May 14, 2015

Filed:

Jan 23, 2015

Appl. No.:

14/604147

Inventors:

- Atlanta GA, US
James FERRARA - Boulder CO, US
James D. MCCHESNEY - Etta MS, US

Assignee:

Tapestry Pharmaceuticals, Inc. - Atlanta GA

International Classification:

A61K 31/357
A61K 31/337

US Classification:

514452, 514449

Abstract:

Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G′ or Formula M′:with a second compound of generalized formula RRC(OCH)and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein Rand Rare each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; Ris an alkyl group, an olefinic group, or an aromatic group; Pis a hydroxyl protecting group; Pis H or an acid labile protecting group at the 7-O position; Ris H, alkyl group, olefinic or aromatic group; and Ris: H, alkyl group, olefinic or aromatic or is as defined in the specification.