James M Shaeffer

US Patent:

8008347, Aug 30, 2011

Filed:

Feb 14, 2007

Appl. No.:

12/279521

Inventors:

Karl A. Schellenberg - Virginia Beach VA, US
Frank A. Lattanzio - Chesapeake VA, US
James Shaeffer - Wytheville VA, US

Assignee:

Eastern Virginia Medical School - Norfolk VA

International Classification:

A61K 31/21
C07C 227/00
A61L 15/00

US Classification:

514513, 558255, 206438

Abstract:

The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the production of free radicals or oxidants such as peroxides, superoxide anions, hydroxyl radicals or nitric oxides, or heavy metal cations. More particularly, the present invention is concerned with methoxypolyethylene glycol thioester chelate methyl esters that are useful as protectors against tissue damage by penetrating the cell membrane to donate electrons to free radical oxidants and remove heavy metals that may react with peroxides to produce the reactive hydroxyl radical, or remove Ca++ that may be released from organelles. These chelate esters will also have utility in reducing intraocular pressure in glaucoma patients.

US Patent:

20080039524, Feb 14, 2008

Filed:

Feb 14, 2007

Appl. No.:

11/705759

Inventors:

Karl Schellenberg - Virginia Beach VA, US
Frank Lattanzio - Chesapeake VA, US
James Shaeffer - Wytheville VA, US

Assignee:

Eastern Virginia Medical School - Norfolk VA

International Classification:

A61K 31/21
A61P 17/18
C07C 327/28

US Classification:

514513000, 558255000

Abstract:

The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the production of free radicals or oxidants such as peroxides, superoxide anions, hydroxyl radicals or nitric oxides, or heavy metal cations. More particularly, the present invention is concerned with methoxypolyethylene glycol thioester chelate methyl esters that are useful as protectors against tissue damage by penetrating the cell membrane to remove electrons from free radical oxidants and remove heavy metals that may react with peroxides to produce the reactive hydroxyl radical, or remove Ca that may be released from organelles. These chelate esters will also have utility in reducing intraocular pressure in glaucoma patients.

US Patent:

20120016030, Jan 19, 2012

Filed:

Jul 22, 2011

Appl. No.:

13/188914

Inventors:

Karl A. SCHELLENBERG - Virginia Beach VA, US
Frank A. LATTANZIO - Chesapeake VA, US
James SHAEFFER - Wytheville VA, US

Assignee:

EASTERN VIRGINIA MEDICAL SCHOOL - Norfolk VA

International Classification:

A61K 31/197
A61P 27/02
A61P 39/04
A61P 27/06

US Classification:

514564

Abstract:

The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the production of free radicals or oxidants such as peroxides, superoxide anions, hydroxyl radicals or nitric oxides, or heavy metal cations. More particularly, the present invention is concerned with methoxypolyethylene glycol thioester chelate methyl esters that are useful as protectors against tissue damage by penetrating the cell membrane to remove electrons from free radical oxidants and remove heavy metals that may react with peroxides to produce the reactive hydroxyl radical, or remove Ca that may be released from organelles. These chelate esters will also have utility in reducing intraocular pressure in glaucoma patients.

US Patent:

46769790, Jun 30, 1987

Filed:

Oct 24, 1985

Appl. No.:

6/791012

Inventors:

Karl A. Schellenberg - Virginia Beach VA
James Shaeffer - Chesapeake VA

Assignee:

Eastern Virginia Medical Authority/Med. Ctr. Hosp. - Norfolk VA

International Classification:

A61K 3174
A61K 3179

US Classification:

424 80

Abstract:

There is disclosed a method of protecting animals including humans against ionizing radiation by injecting the animals with a polymer having the approximate formula H(OCH. sub. 2 CH. sub. 2). sub. n OH, where n varies between 4 and 13. Particularly, it is found that polyethylene glycol (molecular weight between 200 and 600), polyethyleneglycolmonoethylether (molecular weight between 200 and 600), and polyvinylpyrrolidone (molecular weight up to 10,000) when injected into standard experimental animals, such as mice, protects them from the lethal effect of ionizing radiation.

US Patent:

60203730, Feb 1, 2000

Filed:

Apr 21, 1997

Appl. No.:

8/845247

Inventors:

Karl A. Schellenberg - Virginia Beach VA
James Shaeffer - Chesapeake VA
Frank A. Lattanzio - Chesapeake VA

Assignee:

Eastern Virginia Medical School - Norfolk VA

International Classification:

A61K 31225

US Classification:

514547

Abstract:

Derivatives useful in the protection of living organisms against damage due to free radical reactions derived from methoxypolyethylene glycols (MPEG), which are modified by chemically attaching chelating groups in an amide or amine linkage to the nonmethyl end of the polymer. Such chelating groups include ethylene-diamine tetraacetic acid (EDTA), diethylene triamine pentaacetic acid (DTPA), and ethylene glycol aminoethyl ether tetraacetic acid (EGTA), and pharmacologically acceptable salts or esters thereof.