The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 3908 A61K 3810 C12N 708
US Classification:
4241901
Abstract:
The invention provides an immunogen against tetanus toxin including a peptide having a single, linear, antigenic, tetanus-toxin-specific epitope. The epitope is derived from the heavy chain C fragment of the toxin. In a preferred embodiment, the immunogen includes the last 20 amino acids of the toxin, including the carboxy terminus. Antibodies, including antipeptide antibodies, are also provided as well as methods of vaccination.