Jane Patricia Harris

US Patent:

7329663, Feb 12, 2008

Filed:

Jun 29, 2001

Appl. No.:

09/895975

Inventors:

Mark R. Schmitt - Trenton NJ, US
Donald R. Kirsch - Princeton NJ, US
Jane E. Harris - Pennington NJ, US
Carl F. Beyer - Chester NY, US
Klaus-Jüergen Pees - Mainz, DE
Paul A. Carter - Biberach an der Riss, DE
Waldemar Pfrengle - Siebersbach, DE
Guido Albert - Hackenheim, DE

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/519
C07D 487/04

US Classification:

51425931, 544263

Abstract:

The invention provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.