Jason L Liu

US Patent:

20040002095, Jan 1, 2004

Filed:

Mar 20, 2003

Appl. No.:

10/394492

Inventors:

Jason Liu - Concord CA, US
John Breneman - Brentwood CA, US
Arlene Carillo - Vallejo CA, US
Craig Hixson - Benecia CA, US

Assignee:

Bio-Rad Laboratories, Inc. - Hercules CA

International Classification:

C12Q001/68
C07H021/04
C12P019/34
C07K016/46

US Classification:

435/006000, 435/091200, 530/391100, 536/023100

Abstract:

The present invention resides in a detection agent that can be used to amplify a detection signal for a target molecule. The detection agent contains a linear first single-stranded nucleic acid attached to a capture moiety that specific binds the target molecule of interest. The first single-stranded nucleic acid includes a plurality of repeat sequences, each of which is non-homopolymeric and can specifically bind to a second single-stranded nucleic acid that has at least one detectable label. Related method for using the claimed detection agent to amplify a detection signal and a kit for this purpose are also disclosed.

US Patent:

20090042255, Feb 12, 2009

Filed:

Jul 22, 2008

Appl. No.:

12/177579

Inventors:

Jason Yingjie Liu - Foster City CA, US

International Classification:

C12P 19/34

US Classification:

435 911

Abstract:

A method for selectively recovering nucleic acid from a sperm cell in a sample containing cells of at least a sperm cell and an epithelial cell, and a cell suspension medium comprising extracellular impurities, is provided. The method entails introducing a sample into a vessel, sequestering the cells from the remaining sample components, washing the cells with a washing solution either before or after sequestration, removing the impurities-containing cell suspension medium from the vessel while retaining the cells; lysing selectively cells of the first cell type; and isolating the nucleic acid from the lysed cells. Methods for recovering nucleic acid from the second cell type are also provided.

US Patent:

20110159485, Jun 30, 2011

Filed:

Sep 14, 2010

Appl. No.:

12/882194

Inventors:

James Stray - San Mateo CA, US
Jason Yingjie Liu - Foster City CA, US
Maxim Brevnov - Union City CA, US
Jaiprakash Shewale - Santa Clara CA, US
Allison Holt - Burlingame CA, US

Assignee:

LIFE TECHNOLOGIES CORPORATION - Carlsbad CA

International Classification:

C12Q 1/68
C12N 9/50
C12N 9/52
C12N 9/54
C02F 3/34
C12N 9/76
C12N 9/74

US Classification:

435 61, 435219, 435220, 435221, 435262

Abstract:

The present teachings relate to the extraction of nucleic acid from solid materials. Provided are useful compositions, methods and kits for obtaining nucleic acids from a solid biological sample or an adhesive material having a biological material adherent or embedded within the adhesive substrate. The extracted nucleic acid can be used in downstream applications such as genotyping, detection, quantification, and identification of the source of the biological material.

US Patent:

20130101184, Apr 25, 2013

Filed:

Sep 21, 2012

Appl. No.:

13/624799

Inventors:

Michael HARROLD - San Mateo CA, US
Lori HENNESSY - San Mateo CA, US
Jason Yingjie LIU - San Mateo CA, US
Chang ZHONG - Stanford CA, US

Assignee:

LIFE TECHNOLOGIES CORPORATION - Carlsbad CA

International Classification:

G06T 7/00

US Classification:

382124

Abstract:

Systems, methods, and kits are disclosed for collection, labeling and analyzing biological samples containing nucleic acid in conjunction with collecting at least one ridge and valley signature of an individual. Such devices and methods are used in forensic, human identification, access control and screening technologies to rapidly process an individual's identity or determine the identity of an individual.

US Patent:

20220298494, Sep 22, 2022

Filed:

Feb 14, 2020

Appl. No.:

17/431135

Inventors:

- Emeryville CA, US
Christopher BROWN - Emeryville CA, US
Rose KANTOR - Emeryville CA, US
Audra DEVOTO - Emeryville CA, US
Cristina BUTTERFIELD - Emeryville CA, US
Lisa ALEXANDER - Emeryville CA, US
Daniela S.A. GOLTSMAN - Emeryville CA, US
Jason LIU - Emeryville CA, US

International Classification:

C12N 9/22
C12N 15/10
C12N 15/11
C12N 15/90
C12N 15/63

Abstract:

The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

US Patent:

20220220460, Jul 14, 2022

Filed:

Aug 13, 2021

Appl. No.:

17/402426

Inventors:

- Emeryville CA, US
Christopher BROWN - Emeryville CA, US
Rose KANTOR - Emeryville CA, US
Audra DEVOTO - Emeryville CA, US
Cristina BUTTERFIELD - Emeryville CA, US
Lisa ALEXANDER - Emeryville CA, US
Daniela S.A. GOLTSMAN - Emeryville CA, US
Jason LIU - Emeryville CA, US

International Classification:

C12N 9/22
C12N 15/11

Abstract:

The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

US Patent:

20210285037, Sep 16, 2021

Filed:

Mar 23, 2021

Appl. No.:

17/209957

Inventors:

- Carlsbad CA, US
Jason Yingjie LIU - Foster City CA, US

International Classification:

C12Q 1/6851
C12Q 1/6806
C12Q 1/686

Abstract:

A workflow for direct qPCR quantification of unprocessed forensic casework samples is disclosed herein. 13 pg of DNA has been detected by direct amplification from a paper substrate. Direct qPCR quantification of unprocessed forensic casework samples and direct STR amplification of unprocessed forensic casework samples collected on the same PE-swab will greatly increase forensic laboratory's efficiency and capability.

US Patent:

20210008548, Jan 14, 2021

Filed:

Jun 23, 2020

Appl. No.:

16/909626

Inventors:

- Carlsbad CA, US
Jason Yingjie LIU - Foster City CA, US

International Classification:

B01L 3/00

Abstract:

Devices, systems, methods, and kits are disclosed for amplifying small quantities of nucleic acid and identifying the nucleic acid sequences of the amplified nucleic acid products.