Jeffrey Jerome Mitchell

US Patent:

7977462, Jul 12, 2011

Filed:

Apr 18, 2008

Appl. No.:

12/148547

Inventors:

Peter Hornbeck - Magnolia MA, US
Ailan Guo - Burlington MA, US
Klarisa Rikova - Reading MA, US
Albrecht Moritz - Salem MA, US
Charles Farnsworth - Concord MA, US
Matthew Stokes - Beverly MA, US
Jian Yu - Hamilton MA, US
Erik Spek - Cambridge MA, US
Yu Li - Andover MA, US
Anthony Possemato - Framingham MA, US
Jessica Cherry - Durham NH, US
Valerie Goss - Seabrook NH, US
Jeffrey Mitchell - Nashua NH, US
John Rush - Beverly MA, US
Corinne Michaud - Salem MA, US

Assignee:

Cell Signaling Technology, Inc. - Danvers MA

International Classification:

C07K 16/00
C12P 21/08

US Classification:

5303871, 5303877, 5303879, 5303881, 5303888, 53038885, 5303891, 5303897

Abstract:

The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.

US Patent:

20090124023, May 14, 2009

Filed:

May 11, 2007

Appl. No.:

12/227321

Inventors:

Ailan Guo - Burlington MA, US
Jeffrey Mitchell - Nashua NH, US
Peter Hornbeck - Magnolia MA, US

International Classification:

G01N 33/566
C07K 16/18

US Classification:

436501, 5303879

Abstract:

The invention discloses 432 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Acetyltransferases, Adaptor/Scaffold proteins, Actin binding proteins, Adhesion proteins, Apoptosis proteins, Calcium-binding proteins, Cell Cycle Regulation proteins, Cell Surface proteins, DNA binding proteins, DNA replication proteins, Channel proteins, Chaperone proteins, Cellular Metabolism enzymes, Cytoskeletal proteins, DNA repair proteins, Endoplasmic reticulum proteins, Enzyme proteins, G protein and GTPase Activating proteins, Guanine Nucleotide Exchange Factors, Helicase proteins, Isomerase proteins, Extracelluar matrix proteins, Hydrolases, Ligase proteins, Lipid kinases, Inhibtor proteins, Lipid Binding proteins and Lyases.

US Patent:

20090325312, Dec 31, 2009

Filed:

May 11, 2007

Appl. No.:

12/227320

Inventors:

Ailan Guo - Burlington MA, US
Peter Hornbeck - Magnolia MA, US
Jeffrey Mitchell - Nashua NH, US
Yu Li - Andover MA, US

International Classification:

G01N 33/566
C07K 16/18

US Classification:

436501, 5303879

Abstract:

The invention discloses novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Methyltransferases, Transcription factors, Transcription coactivators, Translation initiation complex proteins, Oxireductases, Protein kinases, RNA binding proteins, Secreted proteins, Transferases, Transporter proteins, Ubiquitin conjugating system proteins, Motor proteins, Phosphotases, Proteases, Phospholipases, Receptor proteins and Vesicle proteins.

US Patent:

20100015724, Jan 21, 2010

Filed:

Aug 17, 2007

Appl. No.:

12/310279

Inventors:

Peter Hornbeck - Magnolia MA, US
Ailan Guo - Burlington MA, US
Charles Farnsworth - Concord MA, US
Yu Li - Andover MA, US
Jeffrey Mitchell - Nashua NH, US

International Classification:

G01N 33/53
C07K 16/00

US Classification:

436501, 5303879

Abstract:

The invention discloses 332 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.

US Patent:

20100092992, Apr 15, 2010

Filed:

Aug 17, 2007

Appl. No.:

12/310292

Inventors:

Peter Hornbeck - Magnolia MA, US
Ailan Guo - Burlington MA, US
Charles Farnsworth - Concord MA, US
Yu Li - Andover MA, US
Jeffrey Mitchell - Nashua NH, US

International Classification:

G01N 33/53
C07K 16/00

US Classification:

435 71, 5303879

Abstract:

The invention discloses 322 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.

US Patent:

46480307, Mar 3, 1987

Filed:

Sep 22, 1983

Appl. No.:

6/534782

Inventors:

Frank C. Bomba - Andover MA
Dileep P. Bhandarkar - Westford MA
J. J. Grady - Woburn MA
Stanley A. Lackey - Littleton MA
Jeffrey W. Mitchell - Maynard MA
Reinhard Schumann - Stow MA

Assignee:

Digital Equipment Corporation - Maynard MA

International Classification:

G06F 1300
G06F 1314

US Classification:

364200

Abstract:

One of a plurality of devices on a common communications path (68) has a local memory (54) that is accessible by other devices on the common communications path (68). Another device on the common communications path (68) may include a cache memory (190) that keeps copies of certain of the data contained by the local memory (54). If another device on the common communications path (68) accesses the local memory (54), the cache (190) is kept apprised of this fact by monitoring of the common communications path (68), and it sets an internal flag to indicate that the data involved may not be valid. However, the contents of memory 54 may also be accessed by means of a processor (50) without using the common communications path (68). Accordingly, provisions are made to send an invalidate signal over the common communications path (68) when a non-path access of the local memory (54) has been made to a location to which access was previously afforded over the common communications path ( 68). In this way, non-path accesses of a local memory can be permitted, yet proper invalidation of cache memories can be performed in a simple manner.