Jennifer L Hunt

US Patent:

8034913, Oct 11, 2011

Filed:

Apr 21, 2005

Appl. No.:

11/568023

Inventors:

Jennifer A. Hunt - Raleigh NC, US
Valery Novokhatny - Raleigh NC, US

Assignee:

Grifols Therapeutics Inc. - Research Triangle Park NC

International Classification:

C07H 21/04
C12N 15/63
A61K 31/70

US Classification:

536 232, 536 234, 4353201, 435455

Abstract:

Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.

US Patent:

8231869, Jul 31, 2012

Filed:

Oct 18, 2006

Appl. No.:

12/090782

Inventors:

Philip Scuderi, Jr. - Chapel Hill NC, US
Vikram Arora - Morrisville NC, US
Jennifer A. Hunt - Raleigh NC, US
Valery Novokhatny - Raleigh NC, US

Assignee:

Grifols Therapeutics Inc. - Research Triangle Park NC

International Classification:

A61K 38/48

US Classification:

424 9464

Abstract:

Methods of using polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided, including methods related to vitrectomy or vitreolysis. The plasmin(ogen) molecule has a single kringel domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.

US Patent:

8420079, Apr 16, 2013

Filed:

Sep 1, 2011

Appl. No.:

13/223373

Inventors:

Jennifer Hunt - Raleigh NC, US
Valery Novokhatny - Raleigh NC, US

Assignee:

Grifols Therapeutics, Inc. - Research Triangle Park NC

International Classification:

A61K 38/48
C12N 9/50
A01N 43/04

US Classification:

424 9464, 435219

Abstract:

Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.

US Patent:

20020137888, Sep 26, 2002

Filed:

Jul 30, 2001

Appl. No.:

09/918109

Inventors:

Paul Bernasconi - Chapel Hill NC, US
Ray Carpenter - Durham NC, US
Gary Powell - Morrisville NC, US
Robert Petrovich - Cary NC, US
Kimberly White - Durham NC, US
Jennifer Hunt - Raleigh NC, US

International Classification:

C12Q001/70
C12Q001/68
G01N033/53
C07K002/00
C07K004/00
C07K005/00
C07K007/00
C07K014/00
C07K016/00
C07K017/00
A61K038/00
C07K001/00

US Classification:

530/350000, 435/005000, 435/006000, 435/007100, 530/300000

Abstract:

A parallel high throughput method and kit for the discovery of small molecule interactors of target proteins, in particular, target proteins expressed from entire genomes or subsets thereof. The target module is prepared by binding selectively a target protein, modified to allow its detection, to a surrogate ligand that is linked to an individually detectable bead. Sets of target modules are mixed together in each chamber of a multi-chamber container. A test compound or collection of test compounds is added to each chamber, and the interaction of a compound with each target module is observed. A compound that is specific for a particular target protein will displace that protein from its target module. The identity of the target module so disrupted is determined by identifying the particular bead to which the displaced target protein was attached.

US Patent:

20120009650, Jan 12, 2012

Filed:

Mar 2, 2010

Appl. No.:

13/147491

Inventors:

Edward Koepf - Holly Springs NC, US
Myies Lindsay - Garner NC, US
Rebecca Silverstein - Cary NC, US
Jennifer Hunt - Raleigh NC, US
James Rebbeor - Garner NC, US
Thomas Zimmerman - Raleigh NC, US
Charles Miller - Apex NC, US
Anthony Caronna - Cary NC, US
Kenya Stokes - Cary NC, US

Assignee:

Talecris Biotherapeutics, Inc. - Research Triangle Park NC

International Classification:

C12N 9/68
C07K 14/435
C07K 1/18

US Classification:

435217, 530380

Abstract:

Compositions and methods for preparing plasminogen, in particular recombinant plasminogen, and compositions and methods of utilizing same for preparing plasmin are provided.

US Patent:

20140031532, Jan 30, 2014

Filed:

Mar 14, 2013

Appl. No.:

13/828374

Inventors:

- Barcelona, ES
THOMAS P. ZIMMERMAN - RALEIGH NC, US
JENNIFER A. HUNT - RALEIGH NC, US
CHARLES MILLER - APEX NC, US
SENTHIL RANGANATHAN - CARY NC, US
TONNY DESSOURCES - RALEIGH NC, US

International Classification:

C07K 14/47

US Classification:

530413, 530414, 530416

Abstract:

Described herein are methods for purifying recombinant, cell culture derived alpha-protease inhibitor and removing a colored species that co-purifies with the recA1PI protein. Also described are methods for reducing the iron in cell culture derived alpha-protease inhibitor.

US Patent:

20160304583, Oct 20, 2016

Filed:

Apr 26, 2016

Appl. No.:

15/138682

Inventors:

- Barcelona, ES
Thomas P. Zimmerman - Raleigh NC, US
Jennifer A. Hunt - Raleigh NC, US
Charles Miller - Apex NC, US
Senthil Ranganathan - Cary NC, US
Tonny Dessources - Raleigh NC, US

Assignee:

Grifols, S.A. - Barcelona

International Classification:

C07K 14/81
C12N 7/00
C07K 1/36

Abstract:

Described herein are methods for purifying recombinant, cell culture derived alpha-protease inhibitor and removing a colored species that co-purifies with the recAPI protein. Also described are methods for reducing the iron in cell culture derived alpha-protease inhibitor.

US Patent:

20150329845, Nov 19, 2015

Filed:

Aug 5, 2015

Appl. No.:

14/819001

Inventors:

- Barcelona, ES
Myles Lindsay - Garner NC, US
Rebecca Silverstein - Cary NC, US
Jennifer Hunt - Raleigh NC, US
James Rebbeor - Garner NC, US
Thomas Zimmerman - Raleigh NC, US
Charles Miller - Apex NC, US
Anthony Caronna - Apex NC, US
Kenya Stokes - Durham NC, US

International Classification:

C12N 9/68

Abstract:

Compositions and methods for preparing plasminogen, in particular recombinant plasminogen, and compositions and methods of utilizing same for preparing plasmin are provided.

Address:

4512 Baymar Dr APT 308, Raleigh, NC 27612

VIN:

1G1AL15F877262597

Make:

CHEVROLET

Model:

COBALT

Year:

2007