Jian Ping Luo

US Patent:

6613802, Sep 2, 2003

Filed:

Jun 2, 2000

Appl. No.:

09/585907

Inventors:

Kenneth L. Luskey - Saratoga CA
Jian Luo - Brisbane CA

Assignee:

Metabolex, Inc. - Hayward CA
DiaTex, Inc. - San Antonio TX

International Classification:

A61K 3119

US Classification:

514559, 514891

Abstract:

The present invention provides the use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia.

US Patent:

6624194, Sep 23, 2003

Filed:

Nov 28, 2000

Appl. No.:

09/724788

Inventors:

Kenneth L. Luskey - Saratoga CA
Jian Luo - Brisbane CA
Zuchun Zhao - El Sobrante CA

Assignee:

Metabolex, Inc. - Hayward CA
DiaTex, Inc. - San Antonio CA

International Classification:

A61K 3120

US Classification:

514559, 514866

Abstract:

The present invention provides the use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia. It further provides (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives that are useful for the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia.

US Patent:

6646004, Nov 11, 2003

Filed:

Oct 31, 2000

Appl. No.:

09/703487

Inventors:

Kenneth L. Luskey - Saratoga CA
Jian Luo - Brisbane CA

Assignee:

Metabolex, Inc. - Hayward CA
DiaTex, Inc. - San Antonio TX

International Classification:

A61K 3120

US Classification:

514559, 514866

Abstract:

The present invention provides the use of (-)(3-trihalomethylphenoxy)(4-halophenyl)acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes and hyperlipidemia.

US Patent:

7576131, Aug 18, 2009

Filed:

Mar 4, 2003

Appl. No.:

10/382186

Inventors:

Kenneth L. Luskey - Saratoga CA, US
Jian Luo - Brisbane CA, US

Assignee:

Metabolex, Inc. - Hayward CA
DiaTex, Inc. - San Antonio TX

International Classification:

A61K 31/20

US Classification:

514559

Abstract:

The present invention provides the use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia.

US Patent:

7649110, Jan 19, 2010

Filed:

Feb 25, 2005

Appl. No.:

11/067377

Inventors:

Michelle Akerman - San Francisco CA, US
Jonathan Houze - San Mateo CA, US
Daniel C. H. Lin - Redwood City CA, US
Jinqian Liu - Palo Alto CA, US
Jiwen Liu - Foster City CA, US
Jian Luo - Brisbane CA, US
Zhihua Ma - San Mateo CA, US
Julio C. Medina - San Carlos CA, US
Wei Qiu - Foster City CA, US
Jeffrey D. Reagan - Millbree CA, US
Rajiv Sharma - Fremont CA, US
Michael J. Schmitt - San Francisco CA, US
Stephen J. Shuttleworth - Bourne End, GB
Ying Sun - Albany CA, US
Yingcai Wang - Fremont CA, US
Jian Zhang - Foster City CA, US
Liusheng Zhu - Burlingame CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07C 59/40
C07C 65/03

US Classification:

562471, 562426, 562465

Abstract:

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ—L—P—L—M—X—L—Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

US Patent:

7811593, Oct 12, 2010

Filed:

Mar 10, 2003

Appl. No.:

10/507382

Inventors:

Jian Luo - Brisbane CA, US
Hui Chang Wu - Brisbane CA, US

International Classification:

A61K 9/00

US Classification:

424400

Abstract:

The current invention involves a pharmaceutical composition containing a combination of two active agents. The invention also involves the use of the combination composition to the preparation of a drug combination intended to treat, control and prevent type 2 diabetes and other diseases and conditions that glucose abnormality, including abnormalities in glucose levels and glucose metabolism, is a component.

US Patent:

7816367, Oct 19, 2010

Filed:

Feb 24, 2005

Appl. No.:

10/591214

Inventors:

Michelle Akerman - San Francisco CA, US
Jonathan Houze - San Mateo CA, US
Daniel C. H. Lin - Redwood City CA, US
Jiwen Liu - Foster City CA, US
Jian Luo - Brisbane CA, US
Julio C. Medina - San Carlos CA, US
Wei Qiu - Foster City CA, US
Jeffrey D. Reagan - Millbrae CA, US
Rajiv Sharma - Fremont CA, US
Stephen J. Shuttleworth - Buckinghamshire, GB
Ying Sun - Albany CA, US
Jian Zhang - Foster City CA, US
Liusheng Zhu - Burlingame CA, US
Jinqian Liu - Palo Alto CA, US
Zhihua Ma - San Mateo CA, US
Yingcai Wang - Fremont CA, US
Michael J. Schmitt - San Francisco CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/44
C07D 213/02

US Classification:

514277, 546341

Abstract:

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ-L-P-L-M-X-L-Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

US Patent:

8030354, Oct 4, 2011

Filed:

Oct 3, 2008

Appl. No.:

12/287036

Inventors:

Sean P. Brown - San Francisco CA, US
Qiong Cao - Daly City CA, US
Paul John Dransfield - San Francisco CA, US
Xiaohui Du - Belmont CA, US
Zice Fu - Foster City CA, US
Jonathan Houze - San Mateo CA, US
Xian Yun Jiao - Belmont CA, US
Yong-Jae Kim - Foster City CA, US
Todd J. Kohn - San Mateo CA, US
SuJen Lai - Burlingame CA, US
Daniel Lin - Redwood City CA, US
Jiwen Liu - Foster City CA, US
Jian Luo - Albany CA, US
Julio C. Medina - San Carlos CA, US
Jeffrey D. Reagan - Woodside CA, US
Vatee Pattaropong - Burlingame CA, US
Margrit Schwarz - San Carlos CA, US
Wang Shen - San Mateo CA, US
Yongli Su - Foster City CA, US
Gayathri Swaminath - Fremont CA, US
Marc Vimolratana - San Mateo CA, US
Yingcai Wang - Millbrae CA, US
Yumei Xiong - San Bruno CA, US
Li Yang - San Francisco CA, US
Ming Yu - Foster City CA, US
Jie Zhang - Sunnyvale CA, US
Liusheng Zhu - Foster City CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/192
C07C 53/134

US Classification:

514570, 562496, 562512, 546342, 514357

Abstract:

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I:.