Jin K Park

US Patent:

7521073, Apr 21, 2009

Filed:

Jun 18, 2007

Appl. No.:

11/764469

Inventors:

Richard Rest - Rosemont PA, US
Michael Karin - La Jolla CA, US
Jin Mo Park - Charlestown MA, US

Assignee:

Philadelphia Health and Education Corporation - Philadelphia PA

International Classification:

A61K 35/00
A61P 31/00
C12N 5/00

US Classification:

424780, 435 78, 435170, 435375

Abstract:

Methods for activating Toll-like receptor 4 via cholesterol-dependent cytolysins isolated from a Gram-positive bacteria are provided. In addition compositions containing an isolated cholesterol-dependent cytolysin or a fragment thereof or a mimetic of the cytolysin or fragment thereof and methods for use of such composition in inhibiting binding and/or interaction of Toll-like receptor 4 with endotoxin are provided. Methods for identifying modulators of Toll-like receptor 4 activation by a cholesterol-dependent cytolysin and use of such modulators in treatment of septicemia and/or septic shock are also provided.

US Patent:

7588912, Sep 15, 2009

Filed:

Oct 12, 2005

Appl. No.:

11/248081

Inventors:

Richard Rest - Rosemont PA, US
Michael Karin - La Jolla CA, US
Jin Mo Park - Charlestown MA, US

Assignee:

Regents of the University of California - Oakland CA
Philadelphia Health and Education Corporation - Philadelphia PA

International Classification:

C12Q 1/18
A61K 39/07
A61K 38/00

US Classification:

435 32, 4242461, 514 2

Abstract:

Compounds, methods for identifying compounds and methods for using compounds which modulate interaction of lethal factor and anthrolysin O in the treatment and prevention of anthrax diseases are provided.

US Patent:

20060089305, Apr 27, 2006

Filed:

Oct 12, 2005

Appl. No.:

11/248085

Inventors:

Richard Rest - Rosemont PA, US
Michael Karin - La Jolla CA, US
Jin Park - Charlestown MA, US

International Classification:

A61K 38/16
A61K 38/17

US Classification:

514012000

Abstract:

Methods for activating Toll-like receptor 4 via cholesterol-dependent cytolysins isolated from a Gram-positive bacteria are provided. In addition compositions containing an isolated cholesterol-dependent cytolysin or a fragment thereof or a mimetic of the cytolysin or fragment thereof and methods for use of such composition in inhibiting binding and/or interaction of Toll-like receptor 4 with endotoxin are provided. Methods for identifying modulators of Toll-like receptor 4 activation by a cholesterol-dependent cytolysin and use of such modulators in treatment of septicemia and/or septic shock are also provided.

US Patent:

20130190787, Jul 25, 2013

Filed:

Mar 9, 2013

Appl. No.:

13/792012

Inventors:

Michael Paris - Lansdale PA, US
Adam Dakin - Fort Washington PA, US
Todd Polk - Doylestown PA, US
Mahesh Krishnamoorthy - Lansdale PA, US
Jin Park - Parsippany NJ, US
Michael Longo - Glenmoore PA, US
Peter Hinchiffe - Campbell Hall NY, US

Assignee:

Bioconnect Systems, Inc. - Ambler PA

International Classification:

A61B 17/11

US Classification:

606153

Abstract:

A method of implanting and securing an implantable flow connector in a body of a patient for providing communication of a first space within the body of the patient with a second space within the body of the patient. The method includes providing a flow connector having a lumen having a first orifice and a second orifice, inserting a retention device into the first space within the body, subsequently inserting the flow connector through an opening in the retention device so the second portion of the flow connector extends into the first space within the body and placing the second space within the body over the retention device.

US Patent:

20130197546, Aug 1, 2013

Filed:

Mar 9, 2013

Appl. No.:

13/792019

Inventors:

Michael Paris - Lansdale PA, US
Adam Dakin - Fort Washington PA, US
Todd Polk - Doylestown PA, US
Mahesh Krishnamoorthy - Lansdale PA, US
Jin Park - Parsippany NJ, US
Michael Longo - Glenmoore PA, US
Peter Hinchiffe - Campbell Hall NY, US

Assignee:

Bioconnect Systems, Inc. - Ambler PA

International Classification:

A61B 17/11

US Classification:

606153

Abstract:

A system for coupling a first space within the body of a patient with a second space within the body of the patient including a flow connector insertable into the first and second spaces within the body, the flow connector having a conduit having a lumen having a first orifice at a first portion of the conduit and a second orifice at a second portion of the conduit, the conduit providing communication between the first and second spaces within the body. A retention device retains the conduit with respect to the first space within the body and is engageable with the first space within the body.

US Patent:

20160151066, Jun 2, 2016

Filed:

Feb 6, 2016

Appl. No.:

15/017620

Inventors:

- Fort Washington PA, US
Adam Dakin, JR. - Fort Washington PA, US
Todd Polk - Doylestown PA, US
Mahesh Krishnamoorthy - Lansdale PA, US
Jin Park - Parsippany NJ, US
Michael Longo - Glenmoore PA, US
Peter Hinchliffe - Campbell Hall NY, US

Assignee:

Bioconnect Systems, Inc. - Fort Washington PA

International Classification:

A61B 17/11

Abstract:

A method of implanting and securing an implantable flow connector in a body of a patient for providing communication of a first space within the body of the patient with a second space within the body of the patient. The method includes providing a flow connector having a lumen having a first orifice and a second orifice, inserting a retention device into the first space within the body, subsequently inserting the flow connector through an opening in the retention device so the second portion of the flow connector extends into the first space within the body and placing the second space within the body over the retention device.

US Patent:

20150223817, Aug 13, 2015

Filed:

Apr 27, 2015

Appl. No.:

14/696550

Inventors:

- Fort Washington PA, US
Adam Dakin - Fort Washington PA, US
Todd Polk - Doylestown PA, US
Mahesh Krishnamoorthy - Lansdale PA, US
Jin Park - Parsippany NJ, US
Michael Longo - Glenmoore PA, US
Peter Hinchliffe - Goshen NY, US

Assignee:

Bioconnect Systems, Inc. - Fort Washington PA

International Classification:

A61B 17/11

Abstract:

A system for coupling a first space within the body of a patient with a second space within the body of the patient including a flow connector insertable into the first and second spaces within the body, the flow connector having a conduit having a lumen having a first orifice at a first portion of the conduit and a second orifice at a second portion of the conduit, the conduit providing communication between the first and second spaces within the body. A retention device retains the conduit with respect to the first space within the body and is engageable with the first space within the body.