Jing Liu

US Patent:

6647316, Nov 11, 2003

Filed:

Feb 22, 2001

Appl. No.:

09/790476

Inventors:

Namdar Bahri - Hopkinton MA
Robert Gaskins - Littleton MA
David Levassuer - Billerica MA
Jing Wen Liu - Shrewsbury MA
Thomas Mariano - Londonderry NH
Ted Schnackertz - Tyngsboro MA

Assignee:

PRI Automation, Inc. - Billerica MA

International Classification:

G06F 700

US Classification:

700217, 700216, 700213, 700228, 700229, 700226

Abstract:

A traffic management system for an automatic material handling system (AMHS) divides time into a series of discrete time periods and analyzes a plurality of move requests that are to be executed within a particular time period is disclosed. The traffic management system receives a plurality of move requests from the AMHS and determines how many move requests are to be executed and selects which move requests in particular will be executed in the next time period. The traffic management system prioritizes the selected move requests by analyzing each source node and destination node contained in a move request in conjunction with other node traffic data. The traffic management system analyzes this data to ensure that a move request is not executed if a material transport vehicle would be dispatched to a node having a node traffic balance value that exceeds a predetermined value and a node traffic density value that exceeds a predetermined value.

US Patent:

20130122535, May 16, 2013

Filed:

Nov 9, 2012

Appl. No.:

13/673296

Inventors:

President and Fellows of Harvard College - Cambridge MA, US
Jing Liu - Brookline MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q 1/02

US Classification:

435 29, 536 2722, 530409, 435325

Abstract:

Synthesis of many proteins is tightly controlled at the level of translation and plays an essential role in fundamental processes such as cell growth and proliferation, signaling, differentiation or death. Methods that allow imaging and identification of nascent proteins allow for dissecting regulation of translation, both spatially and temporally, including in whole organisms. Described herein are robust chemical methods for imaging and affinity-purifying nascent polypeptides in cells and in animals, based on puromycin analogs. Puromycin analogs of the present invention form covalent conjugates with nascent polypeptide chains, which are rapidly turned over by the proteasome and can be visualized and specifically captured by a bioorthogonal reaction (e.g., [3+2]cycloaddition). The methods of the present invention have broad applicability for imaging protein synthesis and for identifying proteins synthesized under various physiological and pathological conditions in vivo.

US Patent:

56291566, May 13, 1997

Filed:

Dec 29, 1994

Appl. No.:

8/366422

Inventors:

Jyotsna Shah - Nashua NH
Walter King - Andover MA
Jing Liu - Waltham MA
James Smith - Shrewsbury MA
Eugene Serpe - Winston-Salem NC
Sonya Popoff - Wayland MA

Assignee:

Amoco Corporation - Chicago IL

International Classification:

C12Q 168
C12P 1934

US Classification:

435 6

Abstract:

New methods for performing sandwich assays have been discovered. The assays utilize dual capture probes and eliminate noise resulting from nonspecific binding of detector probe to capture probe.

US Patent:

58495045, Dec 15, 1998

Filed:

May 26, 1995

Appl. No.:

8/452145

Inventors:

Jyotsna Shah - Nashua NH
Amelia Buharin - St. Paul MN
David J. Lane - Milford MA
Jing Liu - Waltham MA

Assignee:

Amoco Corporation - Chicago IL

International Classification:

G01N 3353
C07H 2104
A61K 5100

US Classification:

435 72

Abstract:

The invention features nucleic acid probes and methods for detecting Pneumocystis carinii (e. g. , human or ferret P. carinii) in hybridization assays.

US Patent:

55213006, May 28, 1996

Filed:

Aug 13, 1991

Appl. No.:

7/744282

Inventors:

Jyotsna S. Shah - Nashua NH
Ray M. Nietupski - Millbury MA
Jing Liu - Framingham MA

Assignee:

Norval B. Galloway

International Classification:

C07H 2102
C07H 2104

US Classification:

536 2432

Abstract:

Disclosed are nucleic acid oligonucleotides which are substantially complementary to nucleic acids from Mycobacteria, and subgeneric classes thereof. More specifically, the oligonucleotides are complementary to ribosomal RNA (rRNA) and the DNA encoding rRNA (rDNA). Uses for such oligonucleotides include detection of Mycobacteria by hybridization and amplification of Mycobacterial nucleic acid by polymerase chain reaction.

US Patent:

20160168205, Jun 16, 2016

Filed:

Dec 14, 2015

Appl. No.:

14/968794

Inventors:

- Cambridge MA, US
Jing Liu - Brookline MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C07K 14/00
G01N 33/58

Abstract:

Synthesis of many proteins is tightly controlled at the level of translation and plays an essential role in fundamental processes such as cell growth and proliferation, signaling, differentiation or death. Methods that allow imaging and identification of nascent proteins allow for dissecting regulation of translation, both spatially and temporally, including in whole organisms. Described herein are robust chemical methods for imaging and affinity-purifying nascent polypeptides in cells and in animals, based on puromycin analogs. Puromycin analogs of the present invention form covalent conjugates with nascent polypeptide chains, which are rapidly turned over by the proteasome and can be visualized and specifically captured by a bioorthogonal reaction (e.g., [3+2] cycloaddition). The methods of the present invention have broad applicability for imaging protein synthesis and for identifying proteins synthesized under various physiological and pathological conditions in vivo.