Abstract:
Ris chosen from Calkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, H, OR, N, NRR, COR, SR, with the exception wherein Ris OH Ris selected from the group of H, halogen, N, (CH)R, Rand Rare individually chosen from the group consisting of H, OH, halogen, CN, NO, N, SR, SOR, (CH)RRand Rare selected from the group of H, OH, Halogen, CN, NO, N, SR, SOR, (CH)RX is selected from the group of H, OH, CN, NO, N, halogen Both X and (CH)Rtogether can be O, N—OH Rand Rare selected from the group of H, OR, NRR, C(O)NRR, R, R, OR, COR, C(O)R, Ris chosen from: Ris selected from the group consisting of H, F, SR, ORRis chosen from the group of H, alkyl, alkenyl, alkynyl, aryl, and hydroxyprotecting group, Rand Rare independently selected from the group of H, alkyl, alkenyl, alkynyl, and aryl Y is chosen from CH, CF, CHF, and O, Z is chosen from O, S, B is selected from the group of purine, pyrimidine and heterocycle m is 0, 1, 2, 3, or 4 and pharmaceutically acceptable salts thereof and prodrugs thereof.