Jon C Mitchell

US Patent:

7285632, Oct 23, 2007

Filed:

Dec 23, 2004

Appl. No.:

11/020848

Inventors:

Timothy Denver Hey - Zionsville IN, US
Robin Leola Thompson - Indianapolis IN, US
Thomas Meade - Zionsville IN, US
Sean Michael Russell - Indianapolis IN, US
Joel Jay Sheets - Zionsville IN, US
Justin Michael Lira - Fishers IN, US
Kristin Julee Fencil - Indianapolis IN, US
Jon Christopher Mitchell - West Lafayette IN, US

Assignee:

Dow AgroSciences LLC - Indianapolis IN

International Classification:

C07K 1/00
C07K 14/00
C07K 14/20

US Classification:

530350, 530825

Abstract:

The subject invention relates to novel toxin complex (TC) proteins encoded by genes from strain ILM 104, and methods of controlling an insect with the toxin proteins.

US Patent:

7491698, Feb 17, 2009

Filed:

Jan 7, 2004

Appl. No.:

10/754115

Inventors:

Timothy D. Hey - Zionsville IN, US
Amanda D. Schleper - Westfield IN, US
Scott A. Bevan - Indianapolis IN, US
Scott B. Bintrim - Westfield IN, US
Jon C. Mitchell - West Lafayette IN, US
Ze Sheng Li - Westfield IN, US
Weiting Ni - Carmel IN, US
Baolong Zhu - San Diego CA, US
Donald J. Merlo - Carmel IN, US
Thomas Meade - Zionsville IN, US

Assignee:

Dow AgroSciences LLC - Indianapolis IN

International Classification:

A61K 38/16
A01N 33/04
C07K 14/195

US Classification:

514 12, 424405, 530350

Abstract:

The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from and can be used interchangeably with each other. In particularly preferred embodiments of the subject invention, the toxicity of a “stand-alone” TC protein (from or for example) is enhanced by one or more TC protein “potentiators” derived from a source organism of a different genus from which the toxin was derived. As one skilled in the art will recognize with the benefit of this disclosure, this has broad implications and expands the range of utility that individual types of TC proteins will now be recognized to have. Among the most important advantages is that one skilled in the art will now be able to use a single set of potentiators to enhance the activity of a stand-alone protein toxin as well as a stand-alone protein toxin. (As one skilled in the art knows, toxin proteins tend to be more desirable for controlling lepidopterans while toxin proteins tend to be more desirable for controlling coleopterans. ) This reduces the number of genes, and transformation events, needed to be expressed by a transgenic plant to achieve effective control of a wider spectrum of target pests.

US Patent:

7585944, Sep 8, 2009

Filed:

Sep 18, 2007

Appl. No.:

11/857073

Inventors:

Timothy D. Hey - Zionsville IN, US
Joel J. Sheets - Zionsville IN, US
Thomas Meade - Zionsville IN, US
Justin M. Lira - Fishers IN, US
Sean M. Russell - Indianapolis IN, US
Robin L. Thompson - Indianapolis IN, US
Jon C. Mitchell - West Lafayette IN, US
Kristin Fencil - Indianapolis IN, US

Assignee:

Dow Agrosciences LLC - Indianapolis IN

International Classification:

C07K 1/00
C07K 14/00
C07K 14/20

US Classification:

530350, 530825

Abstract:

The subject invention relates to novel toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from strain ILM104.

US Patent:

7795395, Sep 14, 2010

Filed:

Sep 3, 2009

Appl. No.:

12/553662

Inventors:

Timothy D. Hey - Zionsville IN, US
Joel J. Sheets - Zionsville IN, US
Thomas Meade - Zionsville IN, US
Justin M. Lira - Fishers IN, US
Sean M. Russell - Indianapolis IN, US
Robin L. Thompson - Indianapolis IN, US
Jon C. Mitchell - West Lafayette IN, US
Kristin Fencil - Indianapolis IN, US

Assignee:

Dow AgroSciences LLC - Indianapolis IN

International Classification:

A01H 5/00
C12N 15/00
C12N 15/31
C12N 15/82

US Classification:

530350, 536 231, 536 237, 800279, 800301, 800298, 800295, 800278, 435 691, 435419, 435486

Abstract:

The invention relates to isolated genes encoding toxin complex (TC) proteins, and transgenic plants and host cells expressing toxin complex (TC) proteins and having resistance to insects.

US Patent:

20040194164, Sep 30, 2004

Filed:

Jan 7, 2004

Appl. No.:

10/753901

Inventors:

Scott Bintrim - Westfield IN, US
Jon Mitchell - West Lafayette IN, US
Ignacio Larrinua - Indianapolis IN, US
Susan Green - Nobleville IN, US
Barry Schafer - Cicero IN, US
Scott Bevan - Indianapolis IN, US
Scott Young - Midland MI, US
Lining Guo - Chapel Hill NC, US

Assignee:

Dow AgroSciences, LLC - Indianapolis IN

International Classification:

A01H001/00
C12N015/82
C07H021/04

US Classification:

800/279000, 435/252310, 536/023700, 530/350000, 514/012000

Abstract:

The subject inventions relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifcally, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus strain Xwi. The subject invention also provides an exochitinase obtainable from the Xwi strain. The exochitinase can be used to control insects using methods known in the art.

US Patent:

20080182332, Jul 31, 2008

Filed:

Dec 13, 2007

Appl. No.:

12/001939

Inventors:

Qihua C. Cai - Westfield IN, US
Vipula K. Shukla - Indianapolis IN, US
Joseph F. Petolino - Zionsville IN, US
Lisa W. Baker - Carmel IN, US
Robbi J. Garrison - Fillmore IN, US
Ryan C. Blue - Fishers IN, US
Jon C. Mitchell - Zionsville IN, US
Nicole L. Arnold - Carmel IN, US
Sarah E. Worden - Fillmore IN, US
Jeffrey Miller - Pleasanton CA, US
Fyodor Urnov - Point Richmond CA, US

International Classification:

C12N 15/82
C07K 16/00
C12N 5/00
C07H 21/04

US Classification:

435468, 530402, 536 234, 435419, 435412

Abstract:

Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.

US Patent:

20090042254, Feb 12, 2009

Filed:

Jun 6, 2008

Appl. No.:

12/135071

Inventors:

Diane Retallack - Poway CA, US
Jon C. Mitchell - Zionsville IN, US

Assignee:

DOW GLOBAL TECHNOLOGIES INC. - Midland MI

International Classification:

C12P 21/00
C12N 15/64
C12N 1/21

US Classification:

435 712, 4353201, 43525234

Abstract:

Improved expression of active antibody fragments (Fabs) is achieved by truncating a heavy chain constant region. Truncation of the C1 domain of a Fab fragment can increase yield of soluble active antibody fragment in . Another embodiment of the invention includes secretion of the light chain and a fragment of the heavy chain with various C-termini (e.g., V-C1 truncated to different lengths). The truncated C1 region can be used as a scaffold to create other Fabs. Also included is truncation of the kappa light chain and/or lambda light chain domains of a Fab fragment. The invention also includes expression of Fab fragments fused to other peptides or molecules (e.g., toxins, proteins, peptides, enzymes, etc.).

US Patent:

20090111188, Apr 30, 2009

Filed:

Oct 1, 2008

Appl. No.:

12/286668

Inventors:

Qihua C. Cai - Westfield IN, US
Vipula K. Shukla - Indianapolis IN, US
Joseph F. Petolino - Zionsville IN, US
Lisa W. Baker - Carmel IN, US
Robbi J. Garrison - Fillmore IN, US
Ryan C. Blue - Fishers IN, US
Jon C. Mitchell - Zionsville IN, US
Nicole L. Arnold - Carmel IN, US
Sarah E. Worden - Fillmore IN, US
Jeffrey Miller - Pleasanton CA, US
Fyodor Urnov - Point Richmond CA, US

International Classification:

C12N 15/10

US Classification:

435468

Abstract:

Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.