Jonathan B Rothbard from 501 Beale St UNIT 8D, San Francisco, CA 94105, age 73

Resumes

Sr. Research Scientist At Stanford University

view source

Position:

Sr. Research Scientist at Stanford University, Senior Research Scientist at Stanford University School of Medicine

Location:

San Francisco Bay Area

Industry:

Research

Work:

Stanford University
Sr. Research Scientist
Stanford University School of Medicine since 2007
Senior Research Scientist
ImmuLogic Pharmaceuticals 1989 - 1993
Director

Education:

Columbia University in the City of New York 1973 - 1977

Scientific Founder

view source

Location:

1230 east Napa St, Sonoma, CA 95476

Industry:

Biotechnology

Work:

Lumen Therapeutics
Scientific Founder
Cellgate 2000 - 2004
Founder
Stanford University 2000 - 2004
Senior Research Scientist

Education:

Stanford University 1990 - 2008

Interests:

Cooking
Gardening
Electronics
Home Improvement
Reading
Home Decoration

Name / Title

Company / Classification

Phones & Addresses

Jonathan Rothbard
President

CARDINAL THERAPEUTICS INC
Mfg Biological Products

830 Menlo Ave, Menlo Park, CA 94025
2000 University Ave, Palo Alto, CA 94303

Us Patents

Method And Composition For Enhancing Transport Across Biological Membranes
view source
US Patent:

6495663, Dec 17, 2002
Filed:

Sep 14, 1999
Appl. No.:

09/396195
Inventors:

Jonathan B. Rothbard - Woodside CA
Paul A. Wender - Menlo Park CA
Assignee:

The Board of Trustees of the Leland Stanford Junior University - Stanford CA
International Classification:

C07K 700
US Classification:

530329, 530324, 530325, 530326, 530327, 530328, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17
Abstract:

Methods and compositions for transporting drugs and macromolecules across biological membranes are disclosed. In one embodiment, the invention includes a method for enhancing transport of a selected compound across a biological membrane, wherein a biological membrane is contacted with a conjugate containing a biologically active agent that is covalently attached to a transport polymer. In one embodiment, the polymer consists of from 6 to 25 subunits, at least 50% of which contain a guanidino or amidino sidechain moiety. The polymer is effective to impart to the attached agent a rate of trans-membrane transport across a biological membrane that is greater than the rate of trans-membrane transport of the agent in non-conjugated form.

Compositions And Methods For Enhancing Drug Delivery Across And Into Epithelial Tissues
view source
US Patent:

6593292, Jul 15, 2003
Filed:

Aug 24, 2000
Appl. No.:

09/648400
Inventors:

Jonathan B. Rothbard - Cupertino CA
Paul A. Wender - Menlo Park CA
P. Leo McGrane - Mountain View CA
Lalitha V. S. Sista - Sunnyvale CA
Thorsten A. Kirschberg - Mountain View CA
Assignee:

CellGate, Inc. - Sunnyvale CA
International Classification:

A61K 31496
US Classification:

514 2, 514 11, 514 12, 514 15, 514 16, 514 17, 514159, 514169, 51425407, 514263, 514291, 514423, 514456, 514458, 514634, 514635, 514636, 530300, 530321, 530328, 530329, 530330, 544366
Abstract:

This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length.

Method And Composition For Inhibiting Cardiovascular Cell Proliferation
view source
US Patent:

6605115, Aug 12, 2003
Filed:

Jun 5, 2000
Appl. No.:

09/587647
Inventors:

John P. Cooke - Palo Alto CA
Garrison C. Fathman - Portola Valley CA
Jonathan B. Rothbard - Woodside CA
Shiro Uemura - Nara, JP
Robert C. Robbins - Stanford CA
Murray H. Kown - Menlo Park CA
Assignee:

Board of Trustees of the Leland Stanford Junior University - Stanford CA
International Classification:

A61F 206
US Classification:

623 148, 623 142
Abstract:

Cardiovascular cell proliferation in a blood vessel subjected to trauma, such as angioplasty, vascular graft, anastomosis, or organ transplant, can be inhibited by contacting the vessel with a polymer consisting of from 6 to about 30 amino acid subunits, where at least 50% of the subunits are arginine, and the polymer contains at least six contiguous arginine subunits. Exemplary polymers for this purpose include arginine homopolymers 7 to 15 subunits in length.

Compositions And Methods For Enhancing Drug Delivery Across And Into Epithelial Tissues
view source
US Patent:

6669951, Dec 30, 2003
Filed:

Feb 23, 2001
Appl. No.:

09/792480
Inventors:

Jonathan B. Rothbard - Cupertino CA
Paul A. Wender - Menlo Park CA
P. Leo McGrane - Mountain View CA
Lalitha V. S. Sista - Sunnyvale CA
Thorsten A. Kirschberg - Mountain View CA
Assignee:

CellGate, Inc. - Sunnyvale CA
International Classification:

A61K 902
US Classification:

424436, 514 2, 514 11, 514 16, 514169, 514634, 514636, 530300, 530329, 564236, 564243
Abstract:

This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length.

Compositions And Methods For Treating Inflammatory Diseases Of The Skin
view source
US Patent:

6730293, May 4, 2004
Filed:

Aug 24, 2000
Appl. No.:

09/645689
Inventors:

Jonathan B. Rothbard - Cupertino CA
Paul A. Wender - Menlo Park CA
P. Leo McGrane - Mountain View CA
Lalitha V. S. Sista - Sunnyvale CA
Thorsten A. Kirschberg - Mountain View CA
Assignee:

CellGate, Inc. - Sunnyvale CA
International Classification:

A61K 31765
US Classification:

424 7805, 424 7817, 424 7837, 525 5411
Abstract:

This invention provides compositions and methods for enhancing delivery of glucocorticoids and ascomycins such as hydrocortisone, cyclosporin and FK506 across into and across one or more layers of the skin for the treatment of psoriasis and other inflammatory diseases of the skin.

Compositions And Methods For Enhancing Drug Delivery Across And Into Epithelial Tissues
view source
US Patent:

6759387, Jul 6, 2004
Filed:

Jul 30, 2002
Appl. No.:

10/209421
Inventors:

Jonathan B. Rothbard - Cupertino CA
Paul A. Wender - Menlo Park CA
P. Leo McGrane - Mountain View CA
Lalitha V. S. Sista - Sunnyvale CA
Thorsten A. Kirschberg - Mountain View CA
Assignee:

Cellgate, Inc. - Sunnyvale CA
International Classification:

A61K 31436
US Classification:

514 2, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 51425407, 514291, 514383, 514399, 540461, 544366, 5482666, 5483425
Abstract:

This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length (SEQ ID NO:50).

Guanidinium Transport Reagents And Conjugates
view source
US Patent:

7169814, Jan 30, 2007
Filed:

Dec 11, 2002
Appl. No.:

10/318278
Inventors:

Jonathan B. Rothbard - Woodside CA, US
Paul A. Wender - Menlo Park CA, US
Kanaka Pattabiraman - Menlo Park CA, US
Erin T. Pelkey - Phelps NY, US
Theodore C. Jessop - Palo Alto CA, US
Assignee:

The Board of Trustees of the Leland Stanford Junior University - Stanford CA
Cellgate, Inc. - Sunnyvale CA
International Classification:

A61K 31/155
US Classification:

514565, 554 53, 514 20, 514631, 5483365, 530327, 530328
Abstract:

Transport reagents and conjugates of therapeutic agents linked to transport reagents are described. In particular, the transport reagents have a plurality of guanidinium moieties that are either contiguous or spaced along a backbone, but are sufficiently removed from the backbone via tethers, to allow their interaction with a cell or tissue surface, leading to uptake of the therapeutic agent.

Compositions And Methods For Enhancing Drug Delivery Across And Into Ocular Tissues
view source
US Patent:

7229961, Jun 12, 2007
Filed:

Feb 25, 2002
Appl. No.:

10/083960
Inventors:

Jonathan B. Rothbard - Cupertino CA, US
Paul A. Wender - Menlo Park CA, US
P. Leo McGrane - Mountain View CA, US
Lalitha V. S. Sista - Sunnyvale CA, US
Thorsten A. Kirschberg - Mountain View CA, US
Assignee:

Cellgate, Inc. - Redwood City CA
International Classification:

A61K 31/155
A61K 31/522
A61K 38/03
A61K 38/08
A61K 38/13
A61K 38/16
US Classification:

514 2, 514 11, 514 16, 51426338, 514634, 514636
Abstract:

This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length (SEQ ID NO:86).