Joseph M Gruber

US Patent:

6358971, Mar 19, 2002

Filed:

Dec 4, 2000

Appl. No.:

09/674037

Inventors:

Jesus Ezquerra-Carrera - Madrid, ES
Joseph Michael Gruber - Brownsburg IN
Chafiq Hamdouchi Hamdouchi - Carmel IN
Richard Elmer Holmes - Indianapolis IN
Wayne Alfred Spitzer - Faywood NM

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31437

US Classification:

514300, 546121

Abstract:

The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. wherein: A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR , or COCF ; X is NâOH, O, or CHR ; R is hydrogen, halo, CN, C -C alkyl, âCâCH, CO(C -C alkyl), CO (C -C alkyl), or CONR R ; R and R are independently hydrogen or C -C alkyl; Aâ is hydrogen, halo, C -C alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR , S(O) R , or a group of the formula R is C -C alkyl, phenyl, or substituted phenyl; n is 0, 1, or 2; R is independently at each occurrence hydrogen or halo; m is 1, 2, 3, or 4; and R is hydrogen, halo, CF , OH, CO H, NH , NO , CONHOCH , C -C alkyl, or CO (C -C alkyl), C -C alkoxy; or a pharmaceutically acceptable salt thereof.

US Patent:

6369070, Apr 9, 2002

Filed:

Sep 13, 2000

Appl. No.:

09/646062

Inventors:

Joseph M. Gruber - Brownsburg IN
Julian S Kroin - Indianapolis IN
Bryan H Norman - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 314355

US Classification:

514293, 546 83

US Patent:

6417193, Jul 9, 2002

Filed:

Sep 13, 2000

Appl. No.:

09/646074

Inventors:

Joseph M Gruber - Brownsburg IN
Bryan H Norman - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31443

US Classification:

514293, 546 83

Abstract:

The present invention relates to a compound of formula (I) which is useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.

US Patent:

6743794, Jun 1, 2004

Filed:

May 21, 2002

Appl. No.:

10/130800

Inventors:

Rosanne Bonjouklian - Zionsville IN
Jeffrey Daniel Cohen - Indianapolis IN
Joseph Michael Gruber - Brownsburg IN
Douglas Webb Johnson - Zionsville IN
Louis Nickolaus Jungheim - Indianapolis IN
Julian Stanley Kroin - Indianapolis IN
Peter Ambrose Lander - Indianapolis IN
Ho-Shen Lin - Indianapolis IN
Mark Christopher Lohman - Boulder CO
Brian Stephen Muehl - Greenwood IN
Bryan Hurst Norman - Indianapolis IN
Vinod Francis Patel - Acton MA
Michael Enrico Richett - Indianapolis IN
Kenneth Jeff Thrasher - Indianapolis IN
Sreenivasarao Vepachedu - Palo Alto CA
Wesley Todd White - Indianapolis IN
Yongping Xie - Naperville IL
Jeremy Schulenburg York - Indianapolis IN
Brandon Lee Parkhurst - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31496

US Classification:

51425303, 514293, 5142328, 51425505, 5142285, 514256, 544126, 544 60, 544405, 544333, 544361, 546 83, 546 82

Abstract:

The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).

US Patent:

6221876, Apr 24, 2001

Filed:

Sep 13, 2000

Appl. No.:

9/646063

Inventors:

Joseph Michael Gruber - Brownsburg IN
Sean P Hollinshead - Durham NC
Bryan H Norman - Indianapolis IN
Joseph W Wilson - Durham NC

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 3147
C07D49804

US Classification:

514293

Abstract:

The present invention relates to a compound of formula (I) which is useful for inhibiting neoplasms where the resistance is conferred in part or in total by MRP1. ##STR1##.

US Patent:

20220220068, Jul 14, 2022

Filed:

May 22, 2020

Appl. No.:

17/612240

Inventors:

- INDIANAPOLIS IN, US
BENJAMIN M NUGENT - BROWNSBURG IN, US
GARY D GUSTAFSON - ZIONSVILLE IN, US
STACY T MEYER - ZIONSVILLE IN, US
BRIAN A LOY - INDIANAPOLIS IN, US
JOSEPH M GRUBER - BROWNSBURG IN, US
DAVID M JONES - ZIONSVILLE IN, US
CRUZ AVILA-ADAME - CARMEL IN, US
JEREMY KISTER - CARMEL IN, US
WEIWEI WANG - INDIANAPOLIS IN, US
NICHOLAS BABIJ - CARMEL IN, US
JEFF PETKUS - INDIANAPOLIS IN, US

Assignee:

CORTEVA AGRISCIENCE LLC - INDIANAPOLIS IN

International Classification:

C07C 275/42
A01P 3/00
C07D 277/68
C07D 215/20
C07D 213/30
C07F 7/08
C07D 317/54
C07D 211/46
C07D 211/72
C07C 335/22
C07C 335/32
C07D 295/215
C07D 211/42
C07D 213/61
C07D 231/12
C07D 237/08
C07D 333/16
C07D 239/26
C07D 241/12
A01N 37/52
A01N 43/30
A01N 43/38
A01N 43/40
A01N 43/42
A01N 43/58
A01N 43/60
A01N 47/40
A01N 55/02

Abstract:

This disclosure relates to aryl amidines of Formula I and their use as fungicides.

US Patent:

20150284404, Oct 8, 2015

Filed:

Oct 30, 2013

Appl. No.:

14/438435

Inventors:

- Indianapolis IN, US
Nuria Diaz Buezo - Madrid, ES
Joseph Michael Gruber - Brownsburg IN, US
Douglas Richard Stack - Fishers IN, US

International Classification:

C07D 491/056
C07D 311/76
C07D 265/30
C07D 265/36
C07D 309/04
C07D 319/20
C07D 307/87

Abstract:

The present invention provides compounds of Formula I. Wherein R1, L, and A are as described herein, or a pharmaceutical salt thereof, processes for preparing the compounds, and methods of treating a condition, such as hypertriglyceridemia, using the compounds.