Joshua V Hunter

US Patent:

20160310612, Oct 27, 2016

Filed:

Oct 14, 2014

Appl. No.:

15/029584

Inventors:

- Bothell WA, US
Patrick Burke - Seattle WA, US
Joshua Hunter - Lynnwood WA, US

Assignee:

SEATTLE GENETICS, INC. - Bothell WA

International Classification:

A61K 47/48

Abstract:

The present invention provides Ligand-Drug Conjugates comprising a PEG Unit in a parallel orientation to the Drug Unit. The invention provides inter alia, Ligand-Drug Conjugates (LDCs), methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates are stable in circulation, yet capable of inflicting cell death on targeted cells or inhibiting proliferation of targeted cells once its drug cargo is released in the vicinity or within targeted cells. In principle embodiments, an LDC of the present invention is represented by the structure of Formula I.