Michael E. Hepperle - Boston MA, US Julie Fields Liu - Lexington MA, US Francois Soucy - Stoneham MA, US Yingchun Ye - Durham NH, US Robert S. Murray - Medford MA, US Raman Prakash - Acton MA, US Jeremy D. Little - Wakefield MA, US Alfredo Castro - Winchester MA, US Hormoz Mazdiyasni - Douglas MA, US Paul E. Fleming - Wellesley MA, US Dominic Reynolds - Cambridge MA, US
Michael E. Hepperle - San Diego CA, US Julie Fields Liu - Lexington MA, US R. Scott Rowland - Swampscott MA, US Dilrukshi Vitharana - Somerville MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K 31/437 C07D 413/14 C07D 471/06
US Classification:
5142328, 514292, 544126, 546 87
Abstract:
This invention provides alpha-carboline compounds of formula I:.
Beta-Carbolines Useful For Treating Inflammatory Disease
Michael E. Hepperle - Boston MA, US Julie Fields Liu - Lexington MA, US Francois Soucy - Stoneham MA, US Prakash Raman - Acton MA, US Jeremy D. Little - Wakefield MA, US Paul E. Fleming - Wellesley MA, US Dominic Reynolds - Cambridge MA, US Geraldine C. B. Harriman - Charlestown RI, US
This invention relates to novel compounds that are dihydroindoles derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel dihydroindoles derivatives that are derivatives of silodosin. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering an α-1A-adrenoreceptor antagonist, such as silodosin.
This invention relates to novel tetrahydroisoquinoline derivatives, their derivatives, pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a dual OX-1/OX-2 orexin antagonist.
Michael E. Hepperle - San Diego CA, US Julie Fields Liu - Lexington MA, US R. Scott Rowland - Swampscott MA, US Dilrukshi Vitharana - Somerville MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K 31/437
US Classification:
5142328
Abstract:
This invention provides alpha-carboline compounds of formula I:.
This invention relates to novel substituted isoindoline-1,3-dione derivatives and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogues of apremilast. This invention also provides compositions comprising a compound of this invention and a carrier and the use of disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering apremilast.
This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. In particular, this invention relates to novel substituted xanthine derivatives that are derivatives of a pentoxifylline metabolite. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial. The compounds of the invention are represented by one of the following structural formulas:.
Concert Pharmaceuticals, Inc. Jan 2016 - Jan 2017
Senior Director, R and D Management
Takeda Oncology Jul 1999 - Nov 2006
Senior Scientist I, Medicinal Chemistry
Concert Jul 1999 - Nov 2006
Vice President, R and D Management
Education:
Center For Creative Leadership (Ccl) 2013 - 2013
University of California, Berkeley 1994 - 1999
Doctorates, Doctor of Philosophy, Organic Chemistry
University of North Carolina at Chapel Hill 1990 - 1994
Bachelors, Bachelor of Science, Chemistry
University of California
Skills:
Drug Discovery Medicinal Chemistry Drug Development Biotechnology Organic Chemistry Organic Synthesis Chemistry Pharmaceutical Industry Technology Transfer Life Sciences Drug Design Lc Ms Hplc Lead Change Clinical Development Lifesciences Oncology Nmr Program Management Alliance Management
X-Chem, Inc.
Principal Scientist
Pfizer 2009 - 2012
Research Scientist
Pfizer Dec 2000 - 2009
Reasearch Scientist
Civetta Therapeutics Dec 2000 - 2009
Principal Scientist
Education:
Shanghai Medical University
Masters, Biochemistry
Skills:
Drug Discovery Assay Development Biomarkers Protein Chemistry In Vitro Biotechnology Biochemistry Cell Antibodies Cell Biology Purification Life Sciences Drug Development In Vivo High Throughput Screening Lc Ms Cell Culture Molecular Biology Enzyme Assays Drug Design Immunology Monoclonal Antibodies Elisa Immunoassays Pharmacokinetics Hplc Protein Purification Inflammation Chromatography Lead Change Medicinal Chemistry Transfection Lifesciences Mass Spectrometry Biopharmaceuticals Translational Medicine Western Blotting Protein Expression Pharmacology Bioanalysis Glp Tissue Culture Translational Research Flow Cytometry
2010 to Present Director, Marketing OperationsSound Thinking Boston, MA 2007 to 2009 Market Research SpecialistClub Monaco Boston, MA 2008 to 2008 Sales Associate
Education:
Boston University Boston, MA 2007 to 2010 B.A. in Economics, International Relations
Youtube
DIY Christmas ornaments with Julie Liu
Follow a long with me to make some yummy treats for our tree! We will ...
Duration:
11m 19s
Qigong warm up by julie liu
Today I have qigong warm up before you practice qigong. This is easy f...
Duration:
6m 40s
Julie Liu
... Liu... Julie... ...
Duration:
2m 54s
Go Big Show: The Umbrella Queen Lina Liu Jugg...
The Umbrella Queen, Lina Liu, is popular in China and wants to make a ...
Duration:
3m 57s
Yarn Rainbow Tutorial with Julie Liu
Here's a fun painting tutorial for kids to try at home. Materials: - d...
Duration:
9m 4s
Cultivating Your Marketing Approach for Custo...
Julie Liu is the Senior Vice President of Global Marketing at AvePoint...
Duration:
38m 24s
Googleplus
Julie Liu
Lived:
Hoboken, NJ Beijing, China Somerset, NJ Forest Hills, NY Boston, MA Haledon, NJ
Work:
AvePoint - Director of Global Marketing Operations (2010)
Education:
Boston University - Economics, International Relations, Anthropology
25 Shihua RD,FutianAssistant Merchandiser at Welfaith Past: Marketing Manager at China Citic Bank(Wuhan Credit Card Centre) Work is a mirror,you smile to him,and he will smile to you.
I would like to smile everday no matter what happened.
Do the little thing better,than I can do... Work is a mirror,you smile to him,and he will smile to you.
I would like to smile everday no matter what happened.
Do the little thing better,than I can do the grand thing more better.
Esther Jackson Elementary School Roswell GA 1976-1983, Holcomb Bridge Middle School Alpharetta GA 1983-1984, Crestwood High School Dunwoody GA 1984-1988