Julie J Park

US Patent:

20050090529, Apr 28, 2005

Filed:

Aug 2, 2004

Appl. No.:

10/910217

Inventors:

Indrawan McAlpine - San Diego CA, US
Judith Deal - Wildomar CA, US
Mary Johnson - San Diego CA, US
Susan Kephart - San Diego CA, US
Julie Park - Cambridge MA, US
William Romines - San Diego CA, US
Jayashree Tikhe - San Diego CA, US

International Classification:

A61K031/4439
C07D043/14

US Classification:

514338000, 546268100

Abstract:

3,5 disubstituted indazole compounds with substituted nitrogen bearing 5-membered heterocycles in the 3-position that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating CDK dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.