Jun Liu

Address:

11305 Potomac Oaks Dr, Rockville, MD 20850

VIN:

WBAWB73567P031949

Make:

BMW

Model:

3 SERIES

Year:

2007

US Patent:

6566541, May 20, 2003

Filed:

Mar 21, 2001

Appl. No.:

09/813555

Inventors:

Jun O. Liu - Cambridge MA
Eric C. Griffith - Somerville MA
Zhuang Su - Cambridge MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07D30308

US Classification:

549551, 549554, 549555, 549556, 549558, 549559, 549560, 514475

Abstract:

Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluating an aspect of MetAP2 metabolism or structure; methods for identifying agents that are anti-angiogenic or immunosuppressive comprising evaluating the effect of the agent on an aspect of MetAP2 metabolism; methods for treating a cell having an abnormality in metabolism or structure of MetAP2; and methods for treating abnormal angiogenesis or an immune reaction which results in pathology in an animal. Pharmaceutical compositions are also provided.

US Patent:

6686450, Feb 3, 2004

Filed:

Jun 17, 1999

Appl. No.:

09/335011

Inventors:

Jun O. Liu - Cambridge MA
Luo Sun - Watertown MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 3816

US Classification:

530352, 530350

Abstract:

The present invention provides novel immunosuppressive agents. In particular, the invention provides immunosuppressive agents that bind calcineurin and/or that inhibit interaction between calcineurin and NF-AT. The invention also provides analogs of these agents, nucleic acids encoding the agents and/or their analogs, gene therapy vectors, etc. , and methods of making and using them.

US Patent:

6920398, Jul 19, 2005

Filed:

Jun 10, 2002

Appl. No.:

10/165946

Inventors:

Jun S. Liu - Weston MA, US
Zhaohui Steve Qin - Somerville MA, US
Tianhua Niu - West Roxbury MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

G06F019/00

US Classification:

702 20

Abstract:

Haplotypes for phased genotypic information are determined from unphased genotypic information. One exemplary method includes separating a dataset that includes genotypic information for a plurality of markers for each of a plurality of individuals into subdatasets, each subdataset including the genotypic information for a subset of the plurality of markers; for each subdataset, identifying haplotypes compatible with marker information for each marker of the subset and for each individual of the plurality; and for each individual, assembling the haplotypes from each of the subsets to provide the individual's haplotype with respect to the plurality of markers.

US Patent:

8590799, Nov 26, 2013

Filed:

May 1, 2011

Appl. No.:

13/098475

Inventors:

Jun Liu - Vienna VA, US

International Classification:

G06K 19/06

US Classification:

235494

Abstract:

Systems, methods and apparatus of a secure RFID record are described herein. In one aspect, an apparatus of a RFID wristband comprises three layers: the top layer is a wristband, the middle layer is one RFID tag comprising one RFID chip and one tag antenna covering the wide area of the wristband, the bottom layer is made by anti-irritation materials. In another aspect, an apparatus of a RFID wristband comprises three layers: the top layer is a wristband, the middle layer has two RFID tags, each of which comprises one RFID chip and one tag antenna; the bottom layer is made by anti-irritation materials. In another aspect, a RFID system for secure communication comprises: a tag with at least two memory areas for storing an unique identifier and encoded data, respectively; a reader with at least three functions: key search, decoding process and encoding process; the unique identifier is associated with a key while the key is stored on the reader or a server connected to the reader.

US Patent:

20030125243, Jul 3, 2003

Filed:

Jul 19, 2001

Appl. No.:

09/909269

Inventors:

Jun Liu - Clarksville MD, US
Xuedong Dai - San Jose CA, US
Zhuang Su - Cambridge MA, US

International Classification:

A61K038/12
C07K007/64
C07K005/12

US Classification:

514/009000, 530/317000

Abstract:

The cyclic pentapeptide cyclo(-Arg-Gly-Asp-D-Phe-Lys-) is a highly potent and selective inhibitor for the integrin. A related compound, cyclo(-Arg-Gly-Asp-D-Phe-Val-), is a promising anticancer drug candidate; it has been found to inhibit angiogenesis and induce apoptosis in vascular cells. We have developed a synthesis of arginine containing cyclic peptides using the cyclizcation reagent 1-propanephosphonic acid cyclic anhydride (T3P) and the guanidine protecting group, 2,2,5,7,8-pentamethylchroman-6-sulfonyl (Pbf). This improved synthesis is environmentally friendly and is generally applicable to the synthesis of other cyclic peptides.

US Patent:

20080193499, Aug 14, 2008

Filed:

Jun 27, 2005

Appl. No.:

11/630596

Inventors:

Jun Liu - Clarksville MD, US
Curtis Chong - Baltimore MD, US
David J. Sullivan - Baltimore MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61F 2/00
A61K 31/513
A61K 31/343
A61K 31/58
A61K 31/4196
A61K 31/506
A61K 9/00
A61K 38/50
A61K 31/496

US Classification:

424423, 514274, 514470, 514176, 424 946, 51425407, 424484, 514383, 514256

Abstract:

Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject.

US Patent:

20100330148, Dec 30, 2010

Filed:

Mar 20, 2007

Appl. No.:

12/225391

Inventors:

Jun O. Liu - Clarksville MD, US
Curtis Robert Chong - Honolulu HI, US
David J. Sullivan - Baltimore MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61M 31/00
A61K 38/50
A61K 31/7052
A61K 31/4174
A61K 31/496
A61K 31/4196
A61K 31/506
A61K 31/7072
A61K 31/58
A61P 35/00
A61P 17/00
A61P 7/10
A61P 19/02
A61P 29/00
A61P 3/00

US Classification:

424427, 424 946, 514 43, 514396, 514399, 51425407, 514383, 514256, 514 50, 514176

Abstract:

Described herein are methods of inhibiting IMPDH type 1, and treating or preventing a disease or disorder (or symptoms thereof) associated with IMPDH type 1, wherein an IMPDH type 1 inhibitor compound is administered to a subject.

US Patent:

20100330156, Dec 30, 2010

Filed:

Mar 22, 2010

Appl. No.:

12/729083

Inventors:

Jun O. LIU - Clarksville MD, US
Yunzhao REN - Timonium MD, US
Fan PAN - Baltimore MD, US
Curtis R. CHONG - Honolulu HI, US
Reinhold PENNER - Honolulu HI, US
Jonathan R. BEHR - Cambridge MA, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 31/498
A61K 9/127
A61P 25/28
A61P 25/00
A61P 3/10
A61P 37/00
A61P 1/04
A61P 37/06

US Classification:

424450, 514250

Abstract:

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.