Jun M Liu

US Patent:

6566541, May 20, 2003

Filed:

Mar 21, 2001

Appl. No.:

09/813555

Inventors:

Jun O. Liu - Cambridge MA
Eric C. Griffith - Somerville MA
Zhuang Su - Cambridge MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07D30308

US Classification:

549551, 549554, 549555, 549556, 549558, 549559, 549560, 514475

Abstract:

Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluating an aspect of MetAP2 metabolism or structure; methods for identifying agents that are anti-angiogenic or immunosuppressive comprising evaluating the effect of the agent on an aspect of MetAP2 metabolism; methods for treating a cell having an abnormality in metabolism or structure of MetAP2; and methods for treating abnormal angiogenesis or an immune reaction which results in pathology in an animal. Pharmaceutical compositions are also provided.

US Patent:

6686450, Feb 3, 2004

Filed:

Jun 17, 1999

Appl. No.:

09/335011

Inventors:

Jun O. Liu - Cambridge MA
Luo Sun - Watertown MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 3816

US Classification:

530352, 530350

Abstract:

The present invention provides novel immunosuppressive agents. In particular, the invention provides immunosuppressive agents that bind calcineurin and/or that inhibit interaction between calcineurin and NF-AT. The invention also provides analogs of these agents, nucleic acids encoding the agents and/or their analogs, gene therapy vectors, etc. , and methods of making and using them.

US Patent:

6920398, Jul 19, 2005

Filed:

Jun 10, 2002

Appl. No.:

10/165946

Inventors:

Jun S. Liu - Weston MA, US
Zhaohui Steve Qin - Somerville MA, US
Tianhua Niu - West Roxbury MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

G06F019/00

US Classification:

702 20

Abstract:

Haplotypes for phased genotypic information are determined from unphased genotypic information. One exemplary method includes separating a dataset that includes genotypic information for a plurality of markers for each of a plurality of individuals into subdatasets, each subdataset including the genotypic information for a subset of the plurality of markers; for each subdataset, identifying haplotypes compatible with marker information for each marker of the subset and for each individual of the plurality; and for each individual, assembling the haplotypes from each of the subsets to provide the individual's haplotype with respect to the plurality of markers.

US Patent:

RE40299, May 6, 2008

Filed:

Jan 11, 2000

Appl. No.:

09/481988

Inventors:

Paul J. Bruinsma - San Diego CA, US
Suresh Baskaran - Kennewick WA, US
Jagannadha R. Bontha - Richland WA, US
Jun Liu - Richland WA, US

Assignee:

Battelle Memorial Institute - Richland WA

International Classification:

C01B 33/12

US Classification:

423335, 423336

Abstract:

This invention pertains to surfactant-templated nanometer-scale porosity of a silica precursor solution and forming a mesoporous material by first forming the silica precursor solution into a preform having a high surface area to volume ratio, then rapid drying or evaporating a solvent from the silica precursor solution. The mesoporous material may be in any geometric form, but is preferably in the form of a film, fiber, powder or combinations thereof. The rapid drying or evaporation of solvent from the solution is accomplished by layer thinning, for example spin casting, liquid drawing, and liquid spraying respectively. Production of a film is by layer thinning, wherein a layer of the silica precursor solution is formed on a surface followed by removal of an amount of the silica precursor solution and leaving a geometrically thinner layer of the silica precursor solution from which the solvent quickly escapes via evaporation. Layer thinning may be by any method including but not limited to squeegeeing and/or spin casting. In powder formation by spray drying, the same conditions of fast drying exists as in spin-casting (as well as in fiber spinning) because of the high surface-area to volume ratio of the product.

US Patent:

7412248, Aug 12, 2008

Filed:

Dec 22, 2004

Appl. No.:

11/020752

Inventors:

Justin Paul McNew - Del Mar CA, US
Robert Charles Blakely - Anaheim CA, US
Jun Liu - San Diego CA, US
Khaled I. Dessouky - Studio City CA, US

Assignee:

Technocom Corporation - Encino CA

International Classification:

H04Q 7/20
H04B 7/00
H04M 11/04

US Classification:

4554561, 4554565, 4554566, 455517, 4554042

Abstract:

In one embodiment, a system and method for determining a location of a mobile device are described. A number of different locations for the mobile device is provided using a location determining system. The locations for a number of virtual base stations are determined utilizing the known locations for the mobile device. Then a new location for the mobile device is established based on the determined plurality of locations of the virtual base stations. In one embodiment, a system and method for establishing network references for a first wireless location determining system are described. A plurality of known locations for a mobile device is provided using a second location determining system. Radio signals between the mobile device and base stations of the first wireless location determining system are measured and a plurality of locations for a respective plurality of virtual base stations are determined based on the known locations of the mobile device and the measured radio signals. The determined plurality of locations for the plurality of virtual base stations are then utilized to establish network references for the first wireless location determining system.

US Patent:

8098134, Jan 17, 2012

Filed:

Jun 21, 2007

Appl. No.:

11/766754

Inventors:

John Azevedo - San Marcos CA, US
Rodolfo Monsalvo - Mexico City, MX
Jun Liu - San Diego CA, US

Assignee:

Neology, Inc. - Poway CA

International Classification:

H04Q 5/22

US Classification:

340 102

Abstract:

A multi-document read-write station provides the ability to read/write to a stack of Radio Frequency Identification (RFID) tags within a small area. Specifically, the station provides the ability to read from and write to a tall stack of RFID tagged sheets with the RFID tags stacked one on top of the other. The station and capability described herein is the result of and comprises several components including a closed chamber comprising a document slot, an antenna system, and a power management system.

US Patent:

8284939, Oct 9, 2012

Filed:

Oct 1, 2008

Appl. No.:

12/243409

Inventors:

Thomas Tahan - San Diego CA, US
Jun Liu - San Diego CA, US

Assignee:

Neology, Inc. - Poway CA

International Classification:

H04L 29/06

US Classification:

380270, 380283, 380255, 380 30, 340 101, 340 1051, 340 1042, 340 1052, 713168, 713151

Abstract:

A method for secure cryptographic communication comprises transmitting information that identifies a group key from a first device to a second device. The method further comprises, in the first device, using the group key to encrypt an input vector, transmitting the encrypted input vector, encrypting privacy-sensitive information using a device key, an encryption algorithm, and the input vector, and transmitting the encrypted privacy-sensitive information to the second device.

US Patent:

8334751, Dec 18, 2012

Filed:

Jun 30, 2011

Appl. No.:

13/174684

Inventors:

John Azevedo - San Marcos CA, US
Jeffrey Zhu - Westport CT, US
Eric Mikuteit - San Diego CA, US
Jun Liu - San Diego CA, US

Assignee:

Neology, Inc. - Poway CA

International Classification:

B60R 25/00

US Classification:

340 573, 340 51, 340 52, 340 53, 340 54, 340 55, 340 101, 340 102, 340 103, 340 104, 340 105, 3405721, 3405722, 3405723, 3405724, 3405725, 235375, 235377, 235380, 235384, 235385

Abstract:

A RFID cabinet comprises a cabinet structure and one or more drawers or shelves. Chambers are formed within the cabinet to house the one or more drawers or shelves. An RFID scanner is configured to scan items tagged with RFID tags in the chambers via one or more antennas. The antennas can include transmit and receive antennas or antennas configured to perform both transmit and receive functions. The drawers can have a access cover, or lid that can be controlled so as to control access to the drawer. The scanner can be configured to perform inventory control for the tagged items.