Jun Liu

US Patent:

20030125243, Jul 3, 2003

Filed:

Jul 19, 2001

Appl. No.:

09/909269

Inventors:

Jun Liu - Clarksville MD, US
Xuedong Dai - San Jose CA, US
Zhuang Su - Cambridge MA, US

International Classification:

A61K038/12
C07K007/64
C07K005/12

US Classification:

514/009000, 530/317000

Abstract:

The cyclic pentapeptide cyclo(-Arg-Gly-Asp-D-Phe-Lys-) is a highly potent and selective inhibitor for the integrin. A related compound, cyclo(-Arg-Gly-Asp-D-Phe-Val-), is a promising anticancer drug candidate; it has been found to inhibit angiogenesis and induce apoptosis in vascular cells. We have developed a synthesis of arginine containing cyclic peptides using the cyclizcation reagent 1-propanephosphonic acid cyclic anhydride (T3P) and the guanidine protecting group, 2,2,5,7,8-pentamethylchroman-6-sulfonyl (Pbf). This improved synthesis is environmentally friendly and is generally applicable to the synthesis of other cyclic peptides.

US Patent:

20080193499, Aug 14, 2008

Filed:

Jun 27, 2005

Appl. No.:

11/630596

Inventors:

Jun Liu - Clarksville MD, US
Curtis Chong - Baltimore MD, US
David J. Sullivan - Baltimore MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61F 2/00
A61K 31/513
A61K 31/343
A61K 31/58
A61K 31/4196
A61K 31/506
A61K 9/00
A61K 38/50
A61K 31/496

US Classification:

424423, 514274, 514470, 514176, 424 946, 51425407, 424484, 514383, 514256

Abstract:

Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject.

US Patent:

20100330148, Dec 30, 2010

Filed:

Mar 20, 2007

Appl. No.:

12/225391

Inventors:

Jun O. Liu - Clarksville MD, US
Curtis Robert Chong - Honolulu HI, US
David J. Sullivan - Baltimore MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61M 31/00
A61K 38/50
A61K 31/7052
A61K 31/4174
A61K 31/496
A61K 31/4196
A61K 31/506
A61K 31/7072
A61K 31/58
A61P 35/00
A61P 17/00
A61P 7/10
A61P 19/02
A61P 29/00
A61P 3/00

US Classification:

424427, 424 946, 514 43, 514396, 514399, 51425407, 514383, 514256, 514 50, 514176

Abstract:

Described herein are methods of inhibiting IMPDH type 1, and treating or preventing a disease or disorder (or symptoms thereof) associated with IMPDH type 1, wherein an IMPDH type 1 inhibitor compound is administered to a subject.

US Patent:

20100330156, Dec 30, 2010

Filed:

Mar 22, 2010

Appl. No.:

12/729083

Inventors:

Jun O. LIU - Clarksville MD, US
Yunzhao REN - Timonium MD, US
Fan PAN - Baltimore MD, US
Curtis R. CHONG - Honolulu HI, US
Reinhold PENNER - Honolulu HI, US
Jonathan R. BEHR - Cambridge MA, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 31/498
A61K 9/127
A61P 25/28
A61P 25/00
A61P 3/10
A61P 37/00
A61P 1/04
A61P 37/06

US Classification:

424450, 514250

Abstract:

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

US Patent:

20110124649, May 26, 2011

Filed:

Nov 10, 2008

Appl. No.:

12/742208

Inventors:

Jun O. Liu - Clarksville MD, US
Xiaoyi Hu - San Diego CA, US
Xiaochun Chen - Baltimore MD, US
Dawei Ma - Shanghai, CN
Shridhar Bhat - Cockeysville MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 31/53
C07D 401/04
A61K 31/506
A61P 35/00
A61K 31/517
A61K 31/519

US Classification:

514245, 544328, 514256, 544284, 51426621, 51425217, 544249, 514267, 544212

Abstract:

Described herein are novel pyrimidine-pyridine compounds, methods of inhibiting methionine aminopeptidase and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, wherein a compound of the invention is administered to a subject.

US Patent:

20110176998, Jul 21, 2011

Filed:

Oct 13, 2010

Appl. No.:

12/903842

Inventors:

Martin G. Pomper - Baltimore MD, US
Richard Ambinder - Lutherville MD, US
Jun O. Liu - Clarksville MD, US
Curtis R. Chong - Honolulu HI, US
Jianmeng Chen - Timonium MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 51/00
C07F 5/02
C07C 229/66
C07D 261/18
C07D 235/32
C07H 19/09
C07D 209/46
C07F 5/00
C07F 9/00
C12Q 1/70
C12N 5/09
A61P 29/00
A61P 31/12
A61P 35/00
A61P 31/04

US Classification:

424 173, 544229, 562455, 548248, 5483087, 536 285, 548472, 536 2855, 534 15, 534 10, 435 5, 435375

Abstract:

The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection.

US Patent:

20110262517, Oct 27, 2011

Filed:

Apr 7, 2008

Appl. No.:

12/594777

Inventors:

Jun O. Liu - Clarksville MD, US
Curtis R. Chong - Honolulu HI, US
Jing Xu - Parkville MD, US
Jun Lu - Monmouth Junction NJ, US
Shridhar Bhat - Cockeysville MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 9/00
A61K 31/496
A61P 35/00
A61K 39/395
A61P 27/02
C12Q 1/26
A61K 31/4178

US Classification:

424423, 435 25, 51425407, 514397, 424427, 544366, 4241331

Abstract:

Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject.

US Patent:

20110301163, Dec 8, 2011

Filed:

Oct 6, 2009

Appl. No.:

13/122876

Inventors:

Jun O. Liu - Clarksville MD, US
Joong Sup Shim - Owings Mills MD, US
Curtis R. Chong - Honolulu HI, US
Shridhar Bhat - Cockeysville MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 31/496
C07D 413/10
C07D 401/10
C07D 417/14
C07D 215/34
A61K 31/47
A61K 31/4709
A61K 31/5377
A61P 35/00
A61P 17/00
A61P 29/00
A61P 19/02
A61P 7/10
A61P 27/02
C07D 215/26

US Classification:

5142352, 546179, 546177, 544128, 544363, 546175, 514311, 514314, 51425306

Abstract:

Described herein are methods of inhibiting methionine aminopeptidase or SirT1, inhibiting angiogenesis, and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, SirT1 and/or angiogenesis, wherein a compound of the invention is administered to a subject.