Jun S Liu

US Patent:

6351283, Feb 26, 2002

Filed:

Nov 27, 1996

Appl. No.:

08/755576

Inventors:

Jun Liu - Fremont CA

Assignee:

OmniVision Technologies, Inc. - Sunnyvale CA

International Classification:

H04N 5335

US Classification:

348301, 348302

Abstract:

An improved charge amplifier ( ) for use in a MOS imaging array is disclosed. The charge amplifier comprises a reference capacitor (C ), a sense capacitor (C ), an operational amplifier ( ), a first output capacitor (C ) connected to the output of the operational amplifier, a second output capacitor (C ) connected to the output of the operational amplifier, and a differential amplifier ( ) connected to the first output capacitor and said second output capacitor. In operation, the reference capacitor is charged to a reference voltage. Similarly, the sense capacitor is charged to a reference voltage. Both the sense capacitor and the reference capacitor are formed to be identical. However, the reference capacitor is covered from ambient light and the sense capacitor is exposed to ambient light. As ambient light is incident on the sense capacitor, the voltage carried by the sense capacitor diminishes. After a predetermined exposure time, both the voltage stored across the reference capacitor and the sense capacitor is amplified by the operational amplifier.

US Patent:

6566541, May 20, 2003

Filed:

Mar 21, 2001

Appl. No.:

09/813555

Inventors:

Jun O. Liu - Cambridge MA
Eric C. Griffith - Somerville MA
Zhuang Su - Cambridge MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07D30308

US Classification:

549551, 549554, 549555, 549556, 549558, 549559, 549560, 514475

Abstract:

Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluating an aspect of MetAP2 metabolism or structure; methods for identifying agents that are anti-angiogenic or immunosuppressive comprising evaluating the effect of the agent on an aspect of MetAP2 metabolism; methods for treating a cell having an abnormality in metabolism or structure of MetAP2; and methods for treating abnormal angiogenesis or an immune reaction which results in pathology in an animal. Pharmaceutical compositions are also provided.

US Patent:

6622345, Sep 23, 2003

Filed:

May 29, 2001

Appl. No.:

09/867067

Inventors:

Jun Liu - Milpitas CA
Jeremy L. Neill - Gay GA
Christopher L. Kight - Jackson GA

Assignee:

Hoshizaki America, Inc. - Peachtree City GA

International Classification:

E05D 710

US Classification:

16357, 16374, 16239, 16242, 3121391, 312325, 312326, 312350

Abstract:

A simple and inexpensive hinge system or mechanism that may apply to the front panel or door so as to obtain an easy access to the inside without making the mechanism much more complicated or expensive. The hinge mechanism for a front panel or door is hingedly connected to an enclosure (or cabinet case) and comprises an axis (or shaft) and an axis supporting member having an opening that supports the axis at a first position for door swinging, at a second position for holding the door in a certain state, and at an intermediate position for the axis moving with or without any turning.

US Patent:

6686450, Feb 3, 2004

Filed:

Jun 17, 1999

Appl. No.:

09/335011

Inventors:

Jun O. Liu - Cambridge MA
Luo Sun - Watertown MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 3816

US Classification:

530352, 530350

Abstract:

The present invention provides novel immunosuppressive agents. In particular, the invention provides immunosuppressive agents that bind calcineurin and/or that inhibit interaction between calcineurin and NF-AT. The invention also provides analogs of these agents, nucleic acids encoding the agents and/or their analogs, gene therapy vectors, etc. , and methods of making and using them.

US Patent:

6822628, Nov 23, 2004

Filed:

Jun 28, 2001

Appl. No.:

09/895985

Inventors:

James C. Dunphy - San Jose CA
William Cummings - San Francisco CA
Christopher J. Spindt - Menlo Park CA
Ronald L. Hansen - San Jose CA
Jun (Gordon) Liu - Fremont CA
Lee Cressi - Morgan Hill CA
Colin Stanners - San Jose CA

Assignee:

Candescent Intellectual Property Services, Inc. - Los Gatos CA
Candescent Technologies Corporation - Los Gatos CA

International Classification:

G09G 322

US Classification:

345 752, 345207, 3151691

Abstract:

Methods for compensating for brightness variations in a field emission device. In one embodiment, a method and system are described for measuring the relative brightness of rows of a field emission display (FED) device, storing information representing the measured brightness into a correction table and using the correction table to provide uniform row brightness in the display by adjusting row voltages and/or row on-time periods. A special measurement process is described for providing accurate current measurements on the rows. This embodiment compensates for brightness variations of the rows, e. g. , for rows near the spacer walls. In another embodiment, a periodic signal, e. g. , a high frequency noise signal, is added to the row on-time pulse in order to camouflage brightness variations in the rows near the spacer walls. In another embodiment, the area under the row on-time pulse is adjusted to provide row-by-row brightness compensation based on correction values stored in a memory resident correction table. In another embodiment, the brightness of each row is measured and compiled into a data profile for the FED.

US Patent:

6875432, Apr 5, 2005

Filed:

Oct 4, 2001

Appl. No.:

09/971511

Inventors:

Jun Liu - Pacifica CA, US
Steven J. Shire - Belmont CA, US

Assignee:

Genentech, Inc. - South San Francisco CA
Novartis AG - Basel

International Classification:

A61K038/16
A61K039/345
C07K014/00
C07K016/00

US Classification:

4241301, 4241331, 4241411, 4241431, 4241741, 4241761, 4241771, 514 2, 530350, 5303871, 5303873, 5303881, 53038822, 53038885, 5303897, 5303901, 5303905

Abstract:

The present application concerns concentrated protein formulations with reduced viscosity, which are particularly suitable for subcutaneous administration. The application further concerns a method for reducing the viscosity of concentrated protein formulations.

US Patent:

6887132, May 3, 2005

Filed:

Sep 3, 2002

Appl. No.:

10/234780

Inventors:

Jiro Kajiwara - Saitama-ken, JP
Gerard Moloney - Milpitas CA, US
Jun Liu - Cupertino CA, US
Junsheng Yang - Cupertino CA, US
Ernesto Saldana - San Jose CA, US
Cormac Walsh - Sunnyvale CA, US
Alejandro Reyes - San Jose CA, US

Assignee:

Multi Planar Technologies Incorporated - San Jose CA

International Classification:

B24B001/00

US Classification:

451 41, 451 56, 451 60, 451287, 451444

Abstract:

A polishing apparatus () is provided for polishing a substrate () that has slurry distributor () which improves planarization uniformity. Generally, the apparatus () includes: (i) a platen () with a polishing surface (); (ii) a head () adapted to hold the substrate () against the polishing surface; (iii) a mechanism to rotate the platen () during polishing; (iv) a dispenser () having nozzles () to dispense slurry on the surface (); and (v) a distributor () between the nozzles () and the head (). In one embodiment, the apparatus () further includes a wiper () between the head () and the distributor () to remove used slurry and polishing byproducts from the surface (), thereby reducing agglomerations or deposits that can damage the substrate () and improving yield. Optionally, the apparatus () further includes a dispenser () for dispensing a cleaning fluid before and/or after the wiper () to substantially eliminate buildup of deposits.

US Patent:

6920398, Jul 19, 2005

Filed:

Jun 10, 2002

Appl. No.:

10/165946

Inventors:

Jun S. Liu - Weston MA, US
Zhaohui Steve Qin - Somerville MA, US
Tianhua Niu - West Roxbury MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

G06F019/00

US Classification:

702 20

Abstract:

Haplotypes for phased genotypic information are determined from unphased genotypic information. One exemplary method includes separating a dataset that includes genotypic information for a plurality of markers for each of a plurality of individuals into subdatasets, each subdataset including the genotypic information for a subset of the plurality of markers; for each subdataset, identifying haplotypes compatible with marker information for each marker of the subset and for each individual of the plurality; and for each individual, assembling the haplotypes from each of the subsets to provide the individual's haplotype with respect to the plurality of markers.