Jun L Liu

US Patent:

6566541, May 20, 2003

Filed:

Mar 21, 2001

Appl. No.:

09/813555

Inventors:

Jun O. Liu - Cambridge MA
Eric C. Griffith - Somerville MA
Zhuang Su - Cambridge MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07D30308

US Classification:

549551, 549554, 549555, 549556, 549558, 549559, 549560, 514475

Abstract:

Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluating an aspect of MetAP2 metabolism or structure; methods for identifying agents that are anti-angiogenic or immunosuppressive comprising evaluating the effect of the agent on an aspect of MetAP2 metabolism; methods for treating a cell having an abnormality in metabolism or structure of MetAP2; and methods for treating abnormal angiogenesis or an immune reaction which results in pathology in an animal. Pharmaceutical compositions are also provided.

US Patent:

6686450, Feb 3, 2004

Filed:

Jun 17, 1999

Appl. No.:

09/335011

Inventors:

Jun O. Liu - Cambridge MA
Luo Sun - Watertown MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61K 3816

US Classification:

530352, 530350

Abstract:

The present invention provides novel immunosuppressive agents. In particular, the invention provides immunosuppressive agents that bind calcineurin and/or that inhibit interaction between calcineurin and NF-AT. The invention also provides analogs of these agents, nucleic acids encoding the agents and/or their analogs, gene therapy vectors, etc. , and methods of making and using them.

US Patent:

6920398, Jul 19, 2005

Filed:

Jun 10, 2002

Appl. No.:

10/165946

Inventors:

Jun S. Liu - Weston MA, US
Zhaohui Steve Qin - Somerville MA, US
Tianhua Niu - West Roxbury MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

G06F019/00

US Classification:

702 20

Abstract:

Haplotypes for phased genotypic information are determined from unphased genotypic information. One exemplary method includes separating a dataset that includes genotypic information for a plurality of markers for each of a plurality of individuals into subdatasets, each subdataset including the genotypic information for a subset of the plurality of markers; for each subdataset, identifying haplotypes compatible with marker information for each marker of the subset and for each individual of the plurality; and for each individual, assembling the haplotypes from each of the subsets to provide the individual's haplotype with respect to the plurality of markers.

US Patent:

7230021, Jun 12, 2007

Filed:

Mar 13, 2003

Appl. No.:

10/388257

Inventors:

Daniel Romo - College Station TX, US
Jun Liu - Clarksville MD, US
Nam Song Choi - College Station TX, US
Zonggao Shi - Secane PA, US

Assignee:

The Texas A&M University System - College Station TX

International Classification:

C07D 245/00
C07D 277/00
A61K 31/425
A61K 31/415
A61P 37/00

US Classification:

514368, 514375, 514393, 540456, 540460, 540468, 548201

Abstract:

The present invention provides a compound of Formula I, all of its related stereoisomers, and their pharmaceutically acceptable salts, wherein A—B, K, Q, X, Y, Z, R and R1 are as defined in Claim. The present invention also provides processes for the preparation thereof, the use thereof in treating immune mediated disease and conditions, and pharmaceutical compositions for use in such therapy.

US Patent:

7737134, Jun 15, 2010

Filed:

Oct 6, 2006

Appl. No.:

11/544474

Inventors:

Daniel Romo - College Station TX, US
Jun Liu - Clarksville MD, US
Nam Song Choi - Chenonam, KR
Zonggao Shi - Columbia MO, US
Yongjun Dang - Baltimore MD, US
Tilman Schneider-Poetsch - Erfstadt, DE

Assignee:

The Texas A & M University System - College Station TX
The Johns Hopkins University - Baltimore MD

International Classification:

A01N 43/00
A61K 31/33
C07D 513/00

US Classification:

514183, 540455

Abstract:

Provided herein are compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and C5-methyl groups, also referred to as desmethyl, desamino-pateamine A. Suitable analogs provide anticancer and antiproliferative effects in vivo and in vitro by a novel drug mechanism of action described herein for pateamine A, including inhibition of eIF4A-dependent translation initiation. As with pateamine A, as described herein, suitable analogs cause cell cycle arrest or induce apoptosis in transformed cells. However, toxicity of such compounds to slow growing normal cells is low. In addition, such analogs, like pateamine A, target translation initiation factors and are useful as anticancer and antiproliferative agents in subjects in need thereof. Moreover, the analogs, like pateamine A, are valuable molecular probes for evaluation of eukaryotic translation initiation and as lead compounds for development of improved anticancer agents.

US Patent:

8590799, Nov 26, 2013

Filed:

May 1, 2011

Appl. No.:

13/098475

Inventors:

Jun Liu - Vienna VA, US

International Classification:

G06K 19/06

US Classification:

235494

Abstract:

Systems, methods and apparatus of a secure RFID record are described herein. In one aspect, an apparatus of a RFID wristband comprises three layers: the top layer is a wristband, the middle layer is one RFID tag comprising one RFID chip and one tag antenna covering the wide area of the wristband, the bottom layer is made by anti-irritation materials. In another aspect, an apparatus of a RFID wristband comprises three layers: the top layer is a wristband, the middle layer has two RFID tags, each of which comprises one RFID chip and one tag antenna; the bottom layer is made by anti-irritation materials. In another aspect, a RFID system for secure communication comprises: a tag with at least two memory areas for storing an unique identifier and encoded data, respectively; a reader with at least three functions: key search, decoding process and encoding process; the unique identifier is associated with a key while the key is stored on the reader or a server connected to the reader.

US Patent:

20030125243, Jul 3, 2003

Filed:

Jul 19, 2001

Appl. No.:

09/909269

Inventors:

Jun Liu - Clarksville MD, US
Xuedong Dai - San Jose CA, US
Zhuang Su - Cambridge MA, US

International Classification:

A61K038/12
C07K007/64
C07K005/12

US Classification:

514/009000, 530/317000

Abstract:

The cyclic pentapeptide cyclo(-Arg-Gly-Asp-D-Phe-Lys-) is a highly potent and selective inhibitor for the integrin. A related compound, cyclo(-Arg-Gly-Asp-D-Phe-Val-), is a promising anticancer drug candidate; it has been found to inhibit angiogenesis and induce apoptosis in vascular cells. We have developed a synthesis of arginine containing cyclic peptides using the cyclizcation reagent 1-propanephosphonic acid cyclic anhydride (T3P) and the guanidine protecting group, 2,2,5,7,8-pentamethylchroman-6-sulfonyl (Pbf). This improved synthesis is environmentally friendly and is generally applicable to the synthesis of other cyclic peptides.

US Patent:

20080193499, Aug 14, 2008

Filed:

Jun 27, 2005

Appl. No.:

11/630596

Inventors:

Jun Liu - Clarksville MD, US
Curtis Chong - Baltimore MD, US
David J. Sullivan - Baltimore MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61F 2/00
A61K 31/513
A61K 31/343
A61K 31/58
A61K 31/4196
A61K 31/506
A61K 9/00
A61K 38/50
A61K 31/496

US Classification:

424423, 514274, 514470, 514176, 424 946, 51425407, 424484, 514383, 514256

Abstract:

Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject.