Jun Wei

US Patent:

20220226380, Jul 21, 2022

Filed:

Apr 23, 2020

Appl. No.:

17/605639

Inventors:

- Memphis TN, US
Jun WEI - Memphis TN, US
Terrence GEIGER - Memphis TN, US
Wenting ZHENG - Memphis TN, US

Assignee:

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. - Memphis TN

International Classification:

A61K 35/17
C12N 15/90
C12N 15/11
C12N 9/22
C12N 9/10
C12N 9/16
A61P 35/00
C07K 14/47
A61K 38/46
A61K 31/7088
C12N 15/86
C07K 16/28
C07K 14/705
C07K 14/725

Abstract:

The present application provides methods of enhancing T cell function (e.g., expansion, persistence and/or effector functions), particularly by genetic modification of the Regnase-1, Batf, and additional genes (alone or in combination). The application also provides modified T cells manufactured using the methods provided by this invention and related pharmaceutical compositions. The application further provides methods of using the modified T cells for treating a disease (e.g., a cancer or an infectious disease).