Jun Wei

US Patent:

20110112112, May 12, 2011

Filed:

Oct 7, 2010

Appl. No.:

12/900378

Inventors:

Maurizio Pellecchia - La Jolla CA, US
Jun Wei - La Jolla CA, US

Assignee:

Sanford-Burnham Medical Research Institute - La Jolla CA

International Classification:

A61K 31/496
G01N 33/48
C12N 5/071
A61K 31/135
A61K 31/137
A61K 31/343
A61K 31/497
A61K 31/122
A61K 31/16
C12N 5/09
A61P 25/28
A61P 37/02
A61P 25/00
A61P 25/24
A61P 35/00

US Classification:

51425215, 436 86, 436 94, 435325, 514647, 514651, 514462, 51425304, 514680, 514613

Abstract:

The disclosure provides compounds and methods of using Apogossypolone derivatives for treating diseases and disorders. In particular, the disclosure provides compounds of Formula I:or a pharmaceutically acceptable salt, hydrate, or solvate thereof, and provides methods for the preparation of compounds of Formula I; and methods for treating cancer, autoimmune diseases, and inflammation by administering a compound of Formula I.

US Patent:

20210214365, Jul 15, 2021

Filed:

Jan 14, 2021

Appl. No.:

17/148813

Inventors:

- Richmond VA, US
- La Jolla CA, US
Swadesh K. DAS - Richmond VA, US
Timothy P. KEGELMAN - Richmond VA, US
Bainan WU - Richmond VA, US
Surya K. DE - Richmond VA, US
Jun WEI - La Jolla CA, US
Mitchell E. MENEZES - Richmond VA, US
Luni EMDAD - Richmond VA, US

International Classification:

C07D 487/04
A61P 35/04
A61K 31/519
A61K 45/06
C07D 495/14

Abstract:

Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.

US Patent:

20190263824, Aug 29, 2019

Filed:

Nov 14, 2017

Appl. No.:

16/349467

Inventors:

- Richmond VA, US
- La Jolla CA, US
Swadesh K. DAS - Richmond VA, US
Timothy P. KEGELMAN - Richmond VA, US
Bainan WU - Richmond VA, US
Surya K. DE - Richmond VA, US
Jun WEI - La Jolla CA, US
Mitchell E. MENEZES - Richmond VA, US
Luni EMDAD - Richmond VA, US

International Classification:

C07D 487/04
A61K 45/06
A61K 31/519
A61P 35/04

Abstract:

Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.