Endothelial protein C receptor (EPCR) is found primarily on endothelial cells of large vessels. EPCR translocates from the plasma membrane surface to the nucleus. Molecules which bind to EPCR can be carried from the plasma membrane surface to the nucleus. These molecules include antibodies to EPCR and activated protein C. Protein C, which also binds to EPCR, can be internalized by endothelial cells, but does not enter the nucleus. Thus, EPCR translocation from the plasma membrane to the nucleus provides a means of delivering nucleic acid such as DNA, proteins such as transcription factors, diagnostic agents or other types of drugs to the nucleus of endothelial cells, particularly those on large blood vessels. Conjugates of the materials to be delivered to the nucleus can be formed by ionic or covalent coupling. For example, proteins, including fusion proteins, can be directly conjugated to an anti-EPCR monoclonal antibody.
Jun Xu - Edmond OK, US Charles Esmon - Oklahoma City OK, US
Assignee:
Oklahoma Medical Research Foundation - Oklahoma City OK
International Classification:
C07K 16/24
US Classification:
53038823, 5303881, 5303873
Abstract:
The present invention provides monoclonal antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. Other antibodies inhibit both activated protein C and activation of unactivated protein C. Methods of treatment employing these antibodies are described herein as are methods of screening for and detecting these antibodies.
Extracellular Histones As Biomarkers For Prognosis And Molecular Targets For Therapy
Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.
The present invention provides monoclonal antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. Other antibodies inhibit both activated protein C and activation of unactivated protein C. Methods of treatment employing these antibodies are described herein as are methods of screening for and detecting these antibodies.
System And Method For Systematically Removing Customer Personal Information From An Electronic Device
Joel McCarty - Edmond OK, US Russell Hamlin - Saginaw TX, US Jun Xu - Flower Mound TX, US Scott Wittrock - Flower Mound TX, US
International Classification:
G06F 21/00 G06F 3/048
US Classification:
726 26
Abstract:
A system and method for flashing one or more electronic devices. A flashing program executed by a server is accessed from a computing device. The one or more electronic devices are received for communication with the computing device. The one or more electronic devices are identified in response to receiving the one or more electronic devices. The one or more electronic devices are flashed to remove the customer private information through the computing device as instructed through the server.
- Santa Monica CA, US John Jensen - Santa Monica CA, US Michel Khristo - Santa Monica CA, US Sivakumar Loganathan - San Francisco CA, US Patrick Mandia - Venice CA, US Jun Xu - Marina del Rey CA, US Austin Yeakel - Santa Monica CA, US
International Classification:
H04L 12/58 H04L 29/08
Abstract:
A bidirectional bridge for web view is a technical solution to an engineering challenge associated with presenting external content in a web view. A bidirectional bridge for web view facilitates bidirectional communication between the web view included in the messaging client and the messaging client itself. In response to a user action requesting a web page to be loaded in the web view, the bidirectional bridge initiates a request to messaging client to retrieve external content, receives the requested external content from the messaging client, and displays an image representing the external content in the web view as part of the web page.
Extracellular Histones As Biomarkers For Prognosis And Molecular Targets For Therapy
Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.
Extracellular Histones As Biomarkers For Prognosis And Molecular Targets For Therapy
Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.
Medicine Doctors
Dr. Jun Xu, Staten Island NY - MD (Doctor of Medicine)
Rehabilitation Medicine & Acupuncture 1171 E Putnam Ave STE 1, Riverside, CT 06878 2036377720 (phone)
Education:
Medical School Jiangxi Coll of Trad Chinese Med, Nanchang City, Jiangxi, China Graduated: 1984
Procedures:
Neurological Testing Physical Therapy
Languages:
English
Description:
Dr. Xu graduated from the Jiangxi Coll of Trad Chinese Med, Nanchang City, Jiangxi, China in 1984. He works in Riverside, CT and specializes in Physical Medicine & Rehabilitation. Dr. Xu is affiliated with Stamford Hospital.
Richmond University Medical Center Medicine 355 Bard Ave, Staten Island, NY 10310 7188182430 (phone), 7188183225 (fax)
Education:
Medical School Shanghai Second Med Univ, Shanghai City, Shanghai, China Graduated: 1992
Languages:
English Spanish
Description:
Dr. Xu graduated from the Shanghai Second Med Univ, Shanghai City, Shanghai, China in 1992. He works in Staten Island, NY and specializes in Internal Medicine. Dr. Xu is affiliated with Richmond University Medical Center.
Internship of Penn State's Jan 2014 to 2000Nittany Valley Charter School
Sep 2013 to 2000 part-time Chinese teacherpart-time Guzheng tutor Feb 2012 to 2000Chenyun Musical Instrument Store Fuzhou, CN Jul 2011 to Sep 2011 Guzheng tutorChinese teacher of New Start Training School Fuzhou, CN Mar 2011 to Mar 2011 Chinese teacherActingXiamen, CN Sep 2010 to Sep 2010
Education:
Penn State University Sep 2012 to 2000 Teaching English as a Second LanguageJimei University Sep 2007 to Jul 2011 Bachelor of Arts in Chinese Language and Literature
Phoenix Mobile - General Manager (2006) AIWA SINGAPORE - Mechanical Design Engineer (1995-2001) Venture Singapore - Mechanical Design Engineer (2001-2006)
Education:
Shanghai Jiao Tong University - Mechanical Engineer
Jun Xu
Work:
Rehabilitation Medicine & Acupuncture Center, Greenwich, CT
Education:
New York Medical College - Rehabilitation Medicine, Guangzhou and Jiangxi Colleges of Traditional Chinese Medicine - Acupuncture, Chinese Herbology, Tai Chi, Qi-Qong, Tuina and more
About:
* Graduated from New York Medical College in Rehabilitation Medicine (4 Year program). * Former Chief Resident at New York Medical College. * Graduated from Guangzhou and Jiangxi Colleges of Tradition...
Tagline:
Jun Xu, M.D.
Jun Xu
Tagline:
Genius is also sexy!
Jun Xu
Education:
University of Liverpool - Operations and Supply Chain Management, Liverpool International College - Graduate Diploma
Jun Xu
Work:
Smy
Jun Xu
Jun Xu
Jun Xu
Work:
Microsoft
Youtube
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