Ambikaipakan A Balasubramaniam

US Patent:

7994119, Aug 9, 2011

Filed:

Jul 19, 2005

Appl. No.:

11/658061

Inventors:

Ambikaipakan Balasubramaniam - Cincinnati OH, US

Assignee:

University Of Cincinnati - Cincinnati OH

International Classification:

A61K 38/00
A61P 3/04

US Classification:

514 48, 514 49

Abstract:

This invention relates generally to peptides including tripeptides and to methods for pharmaceutical treatment of mammals using such tripeptides and analogs thereof. More specifically, the invention is directed to neuropeptide Y (“NPY”) receptor antagonists and agonists including O-glycosylated tripeptides, i. e. O-glycopeptides, and extended tripeptides, and their analogs, as well as to PYY analogs, to pharmaceutical compositions containing such tripeptides and PYY analogs, and to methods of treatment of mammals using such tripeptides and PYY analogs. In addition, the invention relates to methods of treatment of mammals using such tripeptides and PYY analogs for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm.

US Patent:

20040209820, Oct 21, 2004

Filed:

May 18, 2004

Appl. No.:

10/848469

Inventors:

Ambikaipakan Balasubramaniam - Cincinnati OH, US
William Chance - Withamsville OH, US

Assignee:

University of Cincinnati - Cincinnati OH

International Classification:

A61K038/05
A61K038/04

US Classification:

514/018000, 514/019000

Abstract:

This invention relates generally to dipeptides and tripeptides and to methods for pharmaceutical treatment of mammals using analogs of such dipeptides and tripeptides. More specifically, the invention relates to tripeptides and their analogs, to pharmaceutical compositions containing such dipeptides and tripeptides and to methods of treatment of mammals using such dipeptides and tripeptides. In addition, the invention relates to methods of treatment of mammals using such dipeptides and tripeptides for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm.

US Patent:

20060009395, Jan 12, 2006

Filed:

Sep 13, 2005

Appl. No.:

11/224759

Inventors:

Ambikaipakan Balasubramaniam - Cincinnati OH, US
William Chance - Withamsville OH, US

Assignee:

University of Cincinnati - Cincinnati OH

International Classification:

A61K 38/05

US Classification:

514018000

Abstract:

This invention relates generally to dipeptides and tripeptides and to methods for pharmaceutical treatment of mammals using analogs of such dipeptides and tripeptides. More specifically, the invention relates to tripeptides and their analogs, to pharmaceutical compositions containing such dipeptides and tripeptides and to methods of treatment of mammals using such dipeptides and tripeptides. In addition, the invention relates to methods of treatment of mammals using such dipeptides and tripeptides for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm.

US Patent:

20070197445, Aug 23, 2007

Filed:

Jan 18, 2006

Appl. No.:

11/333889

Inventors:

Ambikaipakan Balasubramaniam - Cincinnati OH, US

Assignee:

University of Cincinnati - Cincinnati OH

International Classification:

A61K 38/10
C07K 7/08

US Classification:

514014000, 530327000, 530328000

Abstract:

This invention relates generally to neuropeptide Y (“NPY”) Yreceptor agonists including pancreatic polypeptide (PP), analogs thereof, and peptide fragments of PP, e.g. PP(32-36), and analogs thereof, to pharmaceutical compositions containing such Yreceptor agonists, and to methods for treatment of mammals using the same. The NPY Yreceptor agonists may be administered to mammals either alone or in combination with NPY Yreceptor agonists including peptide YY (PYY) (3-36), analogs thereof, and to peptide fragments of PYY(3-36), e.g. PYY(22-36) and PYY(25-36), and analogs thereof, such as to control food intake in mammals, blood pressure, cardiovascular response, libido, circadian rhythm, hyperlipidimia, chronic pancreatitis, and nonalcoholic fatty liver disease including nonalcoholic steatohepatitis.

US Patent:

20090227519, Sep 10, 2009

Filed:

Mar 27, 2008

Appl. No.:

12/056600

Inventors:

Ambikaipakan Balasubramaniam - Cincinnati OH, US

Assignee:

UNIVERSITY OF CINCINNATI - Cincinnati OH

International Classification:

A61K 38/08
C07K 7/06
A61P 3/04

US Classification:

514 17, 530330

Abstract:

This invention relates generally to neuropeptide Y (“NPY”) Yreceptor agonists including pancreatic polypeptide (PP), analogs thereof, and peptide fragments of PP, e.g. PP(32-36), and analogs thereof to pharmaceutical compositions containing such Yreceptor agonists, and to methods for treatment of mammals using the same. The NPY Yreceptor agonists may be administered to mammals either alone or in combination with NPY Yreceptor agonists including peptide (PYY) (3-36), analogs thereof and to peptide fragments of PYY(3-36), e.g. PYY(22-36) and PYY(25-36), and analogs thereof such as to control food intake in mammals, blood pressure, cardiovascular response, libido, circadian rhythm, hyperlipidimia, chronic pancreatitis, and nonalcoholic fatty liver disease including nonalcoholic steatohepatitis.

US Patent:

60461675, Apr 4, 2000

Filed:

Mar 25, 1998

Appl. No.:

9/047986

Inventors:

Ambikaipakan Balasubramaniam - Cincinnati OH

Assignee:

University of Cincinnati - Cincinnati OH

International Classification:

A61K 3807
A61K 3808
A61K 3810
C07C22932
C07K 708

US Classification:

514 13

Abstract:

The invention provides analogs of PYY. The invention also provides compositions and methods useful for controlling biological activities such as cell proliferation, nutrient transport, lipolysis, and intestinal water and electrolyte secretion.

US Patent:

56042035, Feb 18, 1997

Filed:

Oct 24, 1994

Appl. No.:

8/329151

Inventors:

Ambikaipakan Balasubramaniam - Cincinnati OH

Assignee:

University of Cincinnati - Cincinnati OH

International Classification:

A61K 3800
C07K 500
C07K 700
C07K 1700

US Classification:

514 12

Abstract:

The invention provides analogs of PYY. The invention also provides compositions and methods useful for controlling biological activities such as cell proliferation, nutrient transport, lipolysis, and intestinal water and electrolyte secretion.

US Patent:

20140274887, Sep 18, 2014

Filed:

Apr 11, 2014

Appl. No.:

14/250662

Inventors:

Ambikaipakan Balasubramaniam - Cincinnati OH, US

International Classification:

C07K 7/06

US Classification:

514 49, 530330

Abstract:

This invention relates generally to neuropeptide Y (“NPY”) Yreceptor agonists including pancreatic polypeptide (PP), analogs thereof, and peptide fragments of PP, e.g. PP(32-36), and analogs thereof, to pharmaceutical compositions containing such Yreceptor agonists, and to methods for treatment of mammals using the same. The NPY Yreceptor agonists may be administered to mammals either alone or in combination with NPY Yreceptor agonists including peptide YY (PYY) (3-36), analogs thereof, and to peptide fragments of PYY(3-36), e.g. PYY(22-36) and PYY(25-36), and analogs thereof, such as to control food intake in mammals, blood pressure, cardiovascular response, libido, circadian rhythm, hyperlipidimia, chronic pancreatitis, and nonalcoholic fatty liver disease including nonalcoholic steatohepatitis.